Abstract: Disclosed are monoclonal antibodies, binding fragments, and derivatives thereof directed to the human melanocortin-4 receptor, as well as pharmaceutical compositions including the same, and therapeutic uses, including methods for treating cachexia and related conditions and diseases, using such monoclonal antibodies, binding fragments, derivatives, and pharmaceutical compositions.

Abstract: Device for the determination of the amount of substance or the density of fiber structures, which utilizes the elastic properties of the fiber material. By means of a sphere which is positioned in a conical opening in a duct through which the fibers pass and which presses on the fibers with a part of its surface, a nozzle is throttled, so that the pressure on the nozzle represents a measure for the force on the sphere. This pressure is in a definite relationship to the fiber pressure on the sphere and can be measured with a pressure measuring device and transformed into an electrical signal by means of a normal commercially-available converter. A small groove in the wall of the duct behind the sphere avoids the attachment of fibers between the sphere and the opening.