Abstract: What is disclosed is a system and method for determining whether a subject is in atrial fibrillation. A video is received of a region of exposed skin of a subject. The video is acquired of a region where a videoplethysmographic (VPG) signal can be registered by at least one imaging channel of a video imaging device. For each batch of image frames, pixels associated with the region of exposed skin are isolated and processed to obtain a time-series signal. A VPG signal is extracted from the time-series signal. The power spectral density (PSD) is computed across all frequencies within the VPG signal. A pulse harmonic strength (PHS) is calculated for this VPG signal. The pulse harmonic strength is compared to a discrimination threshold, defined herein. A determination is made whether the subject in the video is in atrial fibrillation or in normal sinus rhythm.

Abstract: What is disclosed is a system and method for determining whether a subject is in atrial fibrillation. A video is received of a region of exposed skin of a subject. The video is acquired of a region where a videoplethysmographic (VPG) signal can be registered by at least one imaging channel of a video imaging device. For each batch of image frames, pixels associated with the region of exposed skin are isolated and processed to obtain a time-series signal. A VPG signal is extracted from the time-series signal. The power spectral density (PSD) is computed across all frequencies within the VPG signal. A pulse harmonic strength (PHS) is calculated for this VPG signal. The pulse harmonic strength is compared to a discrimination threshold, defined herein. A determination is made whether the subject in the video is in atrial fibrillation or in normal sinus rhythm.

Abstract: A method for assessing repolarization abnormalities is disclosed. At least two repolarization signals are identified from a set of ECG signals. PCA analysis is performed on the at least two repolarization signals to extract at least eigenvectors ev1 and ev2. A maximum vector MV is determined based on a transformed ECG signal in a plane defined by ev1 and ev2. A repolarization duration is determined which is based on the maximum vector MV. A system for assessing repolarization abnormalities is also disclosed. The system has a processor configured to determine a repolarization duration which is based on a maximum vector MV from transformed ECG repolarization signals in a plane defined by eigenvectors ev1 and ev2 which result from PCA analysis on the ECG repolarization signals. The system also has a data input coupled to the processor and a user interface coupled to either the processor or the data input.

Abstract: A method differentiating LQT1 mutation from LQT2 mutation is disclosed. An ECG signal is obtained for a patient. At least a first ECG parameter and a second ECG parameter are determined from the ECG signal. A probability that the patient is an LQT1 carrier or an LQT2 carrier is determined based on a regression model which takes into account the first ECG parameter and the second ECG parameter. A system for assessing repolarization abnormalities is also disclosed. The system has a processor configured to differentiate between LQT1 and LQT2 based on at least two ECG parameters from ECG data. The system also has a data input coupled to the processor and configured to provide the processor with the ECG data. The system further has a user interface coupled to either the processor or the data input.

Abstract: A method for analyzing an ECG signal includes obtaining a measurement of an area based repolarization interval from at least one beat in the electrocardiogram signal and detecting an altered ventricular repolarization based on the obtained measured area based repolarization interval.

Abstract: A method of assaying impaired delayed rectifier potassium current function is disclosed. One or more electrocardiogram (ECG) signals are obtained. One or more heart rates corresponding to a plurality of beats of the one or more ECG signals are obtained. One or more T-wave amplitudes are determined corresponding to one or more beats of the one or more ECG signals. A determination is made whether the one or more T-wave amplitudes as a function of the one or more heart rates are relatively independent of the corresponding one or more heart rates, thereby indicating impaired delayed rectifier potassium current function. An associated biomarker, system, and method for determining the ability of a pharmacological agent to impair delayed rectifier potassium current function are also disclosed.

Abstract: A method differentiating LQT1 mutation from LQT2 mutation is disclosed. An ECG signal is obtained for a patient. At least a first ECG parameter and a second ECG parameter are determined from the ECG signal. A probability that the patient is an LQT1 carrier or an LQT2 carrier is determined based on a regression model which takes into account the first ECG parameter and the second ECG parameter. A system for assessing repolarization abnormalities is also disclosed. The system has a processor configured to differentiate between LQT1 and LQT2 based on at least two ECG parameters from ECG data. The system also has a data input coupled to the processor and configured to provide the processor with the ECG data. The system further has a user interface coupled to either the processor or the data input.

Abstract: A method for assessing repolarization abnormalities is disclosed. At least two repolarization signals are identified from a set of ECG signals. PCA analysis is performed on the at least two repolarization signals to extract at least eigenvectors ev1 and ev2. A maximum vector MV is determined based on a transformed ECG signal in a plane defined by ev1 and ev2. A repolarization duration is determined which is based on the maximum vector MV. A system for assessing repolarization abnormalities is also disclosed. The system has a processor configured to determine a repolarization duration which is based on a maximum vector MV from transformed ECG repolarization signals in a plane defined by eigenvectors ev1 and ev2 which result from PCA analysis on the ECG repolarization signals. The system also has a data input coupled to the processor and a user interface coupled to either the processor or the data input.

Abstract: A device for the analysis of the alternans cycle to cycle and/or the variability of the ventricular repolarization wave in an ECG signal. This device extracts from an ECG signal, for each cardiac beat, a temporal segment of T samples of the ventricular repolarization wave, considered as from a moment t following a predetermined temporal origin. The T samples for B consecutive beats are aggregated and a local variance factor is evaluated. The square root of the local variance is obtained and weighted by a factor of local alternans. The device delivers at the output an index of alternans and variability TVarb function, for a given beat, local variance factor weighted by the factor of local alternans.

Abstract: A method for analyzing an ECG signal includes obtaining a measurement of an area based repolarization interval from at least one beat in the electrocardiogram signal and detecting an altered ventricular repolarization based on the obtained measured area based repolarization interval.

Abstract: A method for analyzing an ECG signal includes obtaining a measurement of an area based repolarization interval from at least one beat in the electrocardiogram signal and detecting an altered ventricular repolarization based on the obtained measured area based repolarization interval.