Abstract: Described herein is an anti-class II MHC antibody fused to a SARS-CoV-2 antigen. Also described is a vaccine comprising the antibody and methods for treating and/or preventing SARS-CoV-2, wherein the methods comprise administering the antibody to a subject in need thereof. In typical aspects, the vaccine is free of an adjuvant.

Abstract: Described herein is an immunogenic fusion protein comprising: an immunogenic peptide or an immunogenic variant thereof, the immunogenic peptide comprising the following motifs: —KQPAa; QPAKa; PAKQa; or AKQPa; —NPDPb; PNPDb; DPNPb; or PNPDb; —NANPc; ANPNc; NPNAc; or PNANc; —NVDPd; VDPNd; DPNVd; or PNVDd; and —NANPe; ANPNe; NPNAe; or PNANe. wherein a, b, c, d, and e are each independently 0 or greater and wherein a±b±c±d±e is at least 2; and a nanocage monomer peptide.

Abstract: A fusion protein comprises a first nanocage monomer subunit of a nanocage monomer; and a bioactive moiety linked to the first nanocage monomer subunit; wherein the fusion protein self-assembles with a protein comprising a second nanocage monomer subunit to form a nanocage monomer.

Abstract: Described herein are antibodies that target Leukemia Inhibitory Factor (LIF). Also described herein are uses of these antibodies for the treatment of cancer.

Abstract: Described herein are antibodies that target Leukemia Inhibitory Factor (LIF). Also described herein are uses of these antibodies for the treatment of cancer.

Abstract: A prokaryotic expression system or a recombinant adenovirus system is used to highly efficiently express VZV envelope gE glycoprotein and the flagellin fusion protein thereof. The produced recombinant gE protein, gE flagellin fusion protein and recombinant adenovirus vector, or composition thereof is used to immunize a mouse so as to promote the body to generate gE and VZV-specific antibody titer, as well as gE-specific and VZV-specific cell immunity.

Abstract: A fusion protein comprises a nanocage monomer; and an antibody or fragment thereof linked to the nanocage monomer, the antibody or fragment thereof comprising a first member of a binding pair; wherein a plurality of the fusion proteins self-assemble to form a nanocage in which a plurality of the antibodies or fragments thereof decorate the exterior surface of the nanocage, whereby the first member of the binding pair is exposed for interacting with a second member of a binding pair.

Abstract: Described herein are antibodies that target Leukemia Inhibitory Factor (LIF). Also described herein are uses of these antibodies for the treatment of cancer.

Abstract: Described herein are antibodies that target Leukemia Inhibitory Factor (LIF). Also described herein are uses of these antibodies for the treatment of cancer.

Abstract: Described herein are antibodies that target Leukemia Inhibitory Factor (LIF). Also described herein are uses of these antibodies for the treatment of cancer.

Abstract: The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron microscopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

Abstract: The present application relates to novel HIV-1 envelope glycoproteins, which may be utilized as HIV-1 vaccine immunogens, and antigens for crystallization, electron micrsocopy and other biophysical, biochemical and immunological studies for the identification of broad neutralizing antibodies. The present invention encompasses the preparation and purification of immunogenic compositions, which are formulated into the vaccines of the present invention.

Abstract: An assembly composed of a rotary shaft and of a roller bearing supporting said shaft, the bearing including a ring interconnected with the shaft and forming a raceway. The assembly provides that the ring is immobilized in rotation on the shaft by a coupling formed by a plurality of teeth on the shaft cooperating with lugs interconnected with the ring, the lugs being received between said teeth. The ring is retained in an axial direction by a snap ring transversal in the form of a ring portion.

Abstract: A flange covering a disc of a turbine blade to allow ventilation. A diverted face of the disc is provided with a labyrinth seal with lickers to form a seal. Cutters of the lickers are inclined axially and staggered axially and radially, to off-set the center of gravity of a flexible web of the disc and to encourage deformation of the web towards the disc under the effect of centrifugal forces, to reinforce the contact of a bearing face with a pressure plate of the disc. Thus, hooks usually used to unite the periphery of the web to the disc become superfluous.

Abstract: A flange (10) covering a disc (3) of a turbine blade (4) in order to allow ventilation (27, 29) and whose diverted face (24) of the disc (3) is provided with a labyrinth seal (20) with lickers (23) to form a seal, original in that the cutters (37) of the lickers (23) are inclined axially and staggered axially and radially, in order to off-set the center of gravity of the flexible web (14) of the disc and to encourage deformation of the web (14) towards the disc (3) under the effect of centrifugal forces, in order to reinforce the contact of a bearing face (15) with a pressure plate (16) of the disc (3). Thus the hooks usually used to unite the periphery of the web (14) to the disc (3) become superfluous.