Patents by Inventor Jean-Philippe Surivet
Jean-Philippe Surivet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230303486Abstract: The invention relates to compounds of Formula (I) wherein X1, X2, X3, L, RX4, R1, R2A, R2B, R3, R4, R5, and R6 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.Type: ApplicationFiled: June 24, 2021Publication date: September 28, 2023Inventors: Olivier BEZENCON, Caroline DEYMIER, Jens-Uwe PETERS, Romain SIEGRIST, Jean-Philippe SURIVET
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Publication number: 20230136562Abstract: The invention relates to compounds of Formula (I) wherein X1, X2, X3, Y, R1, R2A, R2B, R3, and R4 are as described in the description; to their preparation, to pharmaceutically acceptable salts thereof, to pharmaceutical compositions containing one or more compounds of Formula (I), and to the use of such compounds as medicaments, especially as Kv7 openers.Type: ApplicationFiled: April 27, 2021Publication date: May 4, 2023Inventors: Olivier BEZENCON, Caroline DEYMIER, Jens-Uwe PETERS, Romain SIEGRIST, Jean-Philippe SURIVET
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Publication number: 20190315731Abstract: The invention relates to antibacterial compounds of formula I wherein the group M and R1 are as defined in the claims, and salts thereof.Type: ApplicationFiled: May 16, 2017Publication date: October 17, 2019Inventors: Stefan DIETHELM, Azely MIRRE, Philippe PANCHAUD, Christine SCHMITT, Jean-Luc SPECKLIN, Jean-Philippe SURIVET
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Patent number: 10441576Abstract: The invention relates to antibacterial compounds of formula I wherein M is one of the groups MA, MB and MC represented below and either R1 represents H and R2 represents a cleavable group as defined in the claims or R2 represents H and R1 represents a cleavable group as defined in the claims; and salts thereof.Type: GrantFiled: August 10, 2016Date of Patent: October 15, 2019Assignee: IDORSIA PHARMACEUTICALS LTD.Inventors: Stefan Diethelm, Philippe Panchaud, Georg Rueedi, Jean-Luc Specklin, Jean-Philippe Surivet
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Patent number: 10314823Abstract: The invention relates to antibacterial compounds of formula I wherein M is one of the groups MA, MB and MC represented below wherein R1, MA, MB and MC are as defined in the specification; and to salts thereof.Type: GrantFiled: September 2, 2016Date of Patent: June 11, 2019Assignee: IDORSIA PHARMACEUTICALS LTDInventors: Anne-Catherine Blumstein, Gaelle Mathieu, Loïc Jacob, Florence Masse, Azely Mirre, Philippe Panchaud, Christine Schmitt, Jean-Luc Specklin, Jean-Philippe Surivet
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Publication number: 20190031676Abstract: The invention relates to antibacterial compounds of formula I wherein X represents sulphur or CH?CH; R1 represents H, PO3H2, SO3H, phosphonooxymethyl or the group —CO—R2 wherein R2 is as defined in the claims M is one of the groups MA and MB represented below wherein A represents a bond or C?C and R1A, R2A, R3A and R1B are as defined in the claims; and to salts thereof.Type: ApplicationFiled: August 26, 2016Publication date: January 31, 2019Applicant: IDORSIA PHARMACEUTICALS LTDInventors: Philippe PANCHAUD, Christine SCHMITT, Jean-Philippe SURIVET
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Patent number: 10106544Abstract: The invention relates to antibacterial compounds of formula I wherein R1 is one of the groups represented below wherein A is a bond, CH?CH or C?C; U is N or CH; V is N or CH; W represents N or CH; and R1A, R2A, R3A, R1B and R1C are as defined in the claims; and salts thereof.Type: GrantFiled: March 3, 2015Date of Patent: October 23, 2018Assignee: IDORSIA PHARMACEUTICALS LTDInventors: Gaelle Chapoux, Jean-Christophe Gauvin, Azely Mirre, Philippe Panchaud, Christine Schmitt, Jean-Luc Specklin, Jean-Philippe Surivet
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Publication number: 20180251434Abstract: The invention relates to antibacterial compounds of formula I wherein R1, M, R2, R3, and V are as described in the description, to their preparation, to salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula I, and especially to their use as antibacterial agents.Type: ApplicationFiled: August 30, 2016Publication date: September 6, 2018Inventors: Stefan DIETHELM, Jean-Christophe GAUVIN, Gaelle MATHIEU, Philippe PANCHAUD, Jean-Philippe SURIVET
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Publication number: 20180250273Abstract: The invention relates to antibacterial compounds of formula I wherein M is one of the groups MA, MB and MC represented below wherein R1, MA, MB and MC are as defined in the specification; and to salts thereof.Type: ApplicationFiled: September 2, 2016Publication date: September 6, 2018Applicant: IDORSIA PHARMACEUTICALS LTD.Inventors: Anne-Catherine BLUMSTEIN, Gaelle MATHIEU, Loïc JACOB, Florence MASSE, Azely MIRRE, Philippe PANCHAUD, Christine SCHMITT, Jean-Luc SPECKLIN, Jean-Philippe SURIVET
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Publication number: 20180235938Abstract: The invention relates to antibacterial compounds of formula I wherein M is one of the groups MA, MB and MC represented below and either R1 represents H and R2 represents a cleavable group as defined in the claims or R2 represents H and R1 represents a cleavable group as defined in the claims; and salts thereof.Type: ApplicationFiled: August 10, 2016Publication date: August 23, 2018Inventors: Stefan DIETHELM, Philippe PANCHAUD, Georg RUEEDI, Jean-Luc SPECKLIN, Jean-Philippe SURIVET
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Publication number: 20170355687Abstract: The invention relates to antibacterial compounds formula I wherein R1 is the group M, whereby M is one of the groups MA and MB represented below wherein A is a bond or C?C; R1A is H or halogen; R2A is H or halogen; R3A is H, alkoxy, hydroxyalkoxy, hydroxyalkyl, dihydroxyalkyl, 2-hydroxyacetamido, substituted cycloprop-1-yl or substituted oxetan-3-yl; and R1B is hydroxyalkyl, dihydroxyalkyl, aminoalkyl, dialkylaminoalkyl, substituted cycloprop-1-yl, substituted cyclobutan-1-yl, substituted oxetan-3-yl, 3-hydroxythietan-3-yl, substituted azetidin-3-yl, trans-(cis-3,4-dihydroxy)-cyclopent-1-yl, 3-hydroxymethylbicyclo[1,1,1]pentan-1-yl, 4-hydroxytetrahydro-2H-pyran-4-yl, (3R,6S)-3-aminotetrahydro-2H-pyran-6-yl, piperidin-4-yl or 1-(2-hydroxyacetyppiperidin-4-yl; and salts thereof.Type: ApplicationFiled: November 18, 2015Publication date: December 14, 2017Inventors: Gaelle CHAPOUX, Azely MIRRE, Christine SCHMITT, Jean-Luc SPECKLIN, Jean-Philippe SURIVET
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Patent number: 9822114Abstract: The invention relates to compounds of formula I wherein is a bond or is absent, V is CH, CR6 or N; R0 is H or, if is a bond, may also be alkoxy; R1 is H or halogen; U is CH or N when is a bond, or, if is absent, U is CH2, NH or NR9; R2 is H, alkylcarbonyl or —CH2—R3; R3 is H, alkyl or hydroxyalkyl; R4 is H or, if n is not 0 and R5 is H, may also be OH; R5 is H, alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, carboxy or alkoxycarbonyl; R6 is hydroxyalkyl, carboxy, alkoxycarbonyl or —(CH2)q—NR7R8, q being 1, 2 or 3 and each of R7 and R8 independently being H or alkyl or R7 and R8 forming with the N atom bearing them a ring; R9 is alkyl or hydroxyalkyl; A is —(CH2)p—, —CH2CH2CH(OH)— or —COCH2CH(OH)—; G is substituted phenyl or G1 or G2 wherein Q is O or S and X is CH or N; and Y1, Y2 and Y3 may each be CH or N; and n is 0 when A is —CH2CH2CH(OH)— or —COCH2CH(OH)—, and n is 0, 1 or 2 when A is —(CH2)p—, p being 1, 2, 3 or 4, with the proviso that the sum of n and p is then 2, 3 or 4; and to salts thereType: GrantFiled: April 21, 2016Date of Patent: November 21, 2017Assignee: IDORSIA PHARMACEUTICALS LTDInventors: Christian Hubschwerlen, Daniel Ritz, Georg Rueedi, Jean-Philippe Surivet, Cornelia Zumbrunn-Acklin
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Patent number: 9802901Abstract: The invention relates to antibacterial compounds of formula I wherein R1 is H or halogen; R2 is alkynyloxy or the group M; R3 is H or halogen; M is one of the groups wherein A is a bond, CH2CH2, CH?CH or C?C and R1A, R2A, R3A, R1B and R1C are as defined in claim 1; and salts thereof.Type: GrantFiled: September 12, 2014Date of Patent: October 31, 2017Assignee: IDORSIA PHARMACEUTICALS LTDInventors: Jean-Christophe Gauvin, Azely Mirre, Etienne Ochala, Jean-Philippe Surivet
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Patent number: 9796686Abstract: The invention relates to antibacterial compounds of formula I wherein R1 is H or halogen; R2 is the group M; R3 is H or halogen; M is MA or MB wherein A is a bond or C?C; R1A is H or halogen; R2A is H, alkoxy or halogen; R3A is H, alkoxy, hydroxyalkoxy, hydroxyalkyl, 1,2-dihydroxyethyl, dialkylamino, 1-hydroxymethyl-cycloprop-1-yl, 1-((dimethylglycyl)oxy)methyl-cycloprop-1-yl, 3-hydroxyoxetan-3-yl, morpholin-4-ylalkyl or morpholin-4-ylalkoxy; and R1B is a group as defined in claim 1; and salts thereof.Type: GrantFiled: May 13, 2015Date of Patent: October 24, 2017Assignee: IDORSIA PHARMACEUTICALS LTDInventors: Gaëlle Chapoux, Jean-Christophe Gauvin, Azely Mirre, Jean-Philippe Surivet
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Publication number: 20170107223Abstract: The invention relates to antibacterial compounds of formula I wherein R1 is one of the groups represented below wherein A is a bond, CH?CH or C?C; U is N or CH; V is N or CH; W represents N or CH; and R1A, R2A, R3A, R1B and R1C are as defined in the claims; and salts thereof.Type: ApplicationFiled: March 3, 2015Publication date: April 20, 2017Inventors: Gaelle CHAPOUX, Jean-Christophe GAUVIN, Azely MIRRE, Philippe PANCHAUD, Christine SCHMITT, Jean-Luc SPECKLIN, Jean-Philippe SURIVET
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Patent number: 9624206Abstract: The invention relates to antibacterial compounds of formula I wherein X is N or CH; R1 is H or halogen; R2 is alkynyloxy or the group M; R3 is H or halogen; M is one of the groups MA and MB represented below wherein A is a bond, CH2CH2, CH?CH or C?C; R1A is H or halogen; R2A is H, alkoxy or halogen; R3A is H, alkoxy, hydroxyalkoxy, alkoxyalkoxy, thioalkoxy, trifluoromethoxy, amino, hydroxyalkyl, 2-hydroxyacetamido, 1-aminocyclopropyl, 1-hydroxymethyl-cycloprop-1-yl, 1-((phosphonooxy)methyl)cyclopropyl, 1-(((dimethylglycyl)oxy)methyl)cyclopropyl, trans-2-hydroxymethyl-cycloprop-1-yl, 1,2-dihydroxyethyl, 3-hydroxyoxetan-3-yl, 3-(hydroxyalkyl)oxetan-3-yl, 3-aminooxetan-3-yl, 3-hydroxythietan-3-yl, morpholin-4-ylalkoxy, morpholin-4-yl-alkyl, oxazol-2-yl or [1,2,3]triazol-2-yl; and R1B is hydroxyalkyl, dihydroxyalkyl, aminoalkyl, 1-hydroxymethyl-cycloprop-1-yl, 1-aminomethyl-cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, 3-hydroxyoxetan-3-yl, 3-hydroxythietan-3-yl, 1-(2-hydroxyacetyl)azetidin-3-yl,Type: GrantFiled: December 18, 2014Date of Patent: April 18, 2017Assignee: ACTELION PHARMACEUTICALS LTDInventors: Gaelle Chapoux, Jean-Christophe Gauvin, Christian Hubschwerlen, Azely Mirre, Etienne Ochala, Jean-Luc Specklin, Jean-Philippe Surivet
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Publication number: 20170081292Abstract: The invention relates to antibacterial compounds of formula I wherein R1 is H or halogen; R2 is the group M; R3 is H or halogen; M is MA or MB wherein A is a bond or C?C; R1A is H or halogen; R2A is H, alkoxy or halogen; R3A is H, alkoxy, hydroxyalkoxy, hydroxyalkyl, 1,2-dihydroxyethyl, dialkylamino, 1-hydroxymethyl-cycloprop-1-yl, 1-((dimethylglycyl)oxy)methyl-cycloprop-1-yl, 3-hydroxyoxetan-3-yl, morpholin-4-ylalkyl or morpholin-4-ylalkoxy; and R1B is a group as defined in claim 1; and salts thereof.Type: ApplicationFiled: May 13, 2015Publication date: March 23, 2017Inventors: Gaëlle CHAPOUX, Jean-Christophe GAUVIN, Azely MIRRE, Jean-Philippe SURIVET
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Publication number: 20170029411Abstract: The invention relates to antibacterial compounds of formula I wherein X is N or CH; R1 is H or halogen; R2 is alkynyloxy or the group M; R3 is H or halogen; M is one of the groups MA and MB represented below wherein A is a bond, CH2CH2, CH?CH or C?C; R1A is H or halogen; R2A is H, alkoxy or halogen; R3A is H, alkoxy, hydroxyalkoxy, alkoxyalkoxy, thioalkoxy, trifluoromethoxy, amino, hydroxyalkyl, 2-hydroxyacetamido, 1-aminocyclopropyl, 1-hydroxymethyl-cycloprop-1-yl, 1-((phosphonooxy)methyl)cyclopropyl, 1-(((dimethylglycyl)oxy)methyl)cyclopropyl, trans-2-hydroxymethyl-cycloprop-1-yl, 1,2-dihydroxyethyl, 3-hydroxyoxetan-3-yl, 3-(hydroxyalkyl)oxetan-3-yl, 3-aminooxetan-3-yl, 3-hydroxythietan-3-yl, morpholin-4-ylalkoxy, morpholin-4-yl-alkyl, oxazol-2-yl or [1,2,3]triazol-2-yl; and R1B is hydroxyalkyl, dihydroxyalkyl, aminoalkyl, 1-hydroxymethyl-cycloprop-1-yl, 1-aminomethyl-cycloprop-1-yl, trans-2-hydroxymethyl-cycloprop-1-yl, 3-hydroxyoxetan-3-yl, 3-hydroxythietan-3-yl, 1-(2-hydroxyacetyl)azetidin-3-yl,Type: ApplicationFiled: December 18, 2014Publication date: February 2, 2017Applicant: ACTELION PHARMACEUTICALS LTDInventors: Gaelle CHAPOUX, Jean-Christophe GAUVIN, Christian HUBSCHWERLEN, Azely MIRRE, Etienne OCHALA, Jean-Luc SPECKLIN, Jean-Philippe SURIVET
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Patent number: 9505750Abstract: The invention relates to antibacterial compounds of formula I wherein one or two of U, V, W, and X represent N, the rest represent CH or, in the case of X, may also represent CRa wherein Ra is fluorine; R1 represents alkoxy, halogen or cyano; R2 represents H, CH2OH, CH2N3, CH2NH2, alkylcarbonylaminomethyl or triazol-1-ylmethyl; R3 represents H, or, when n is 1, R3 may also represent OH, NH2, NHCOR6 or triazol-1-yl; A represents CR4; K represents O, NH, OCH2, NHCO, NHCH2, CH2NH, CH2CH2, CH?CH, CHOHCHOH or CHR5; R4 represents H or together with R5 forms a bond, or also R4 can represent OH when K is not O, NH, OCH2 or NHCO; R5 represents OH or together with R4 forms a bond; R6 represents alkyl; m is 0 or 1 and n is 0 or 1; and G is as defined in the description; and to salts of such compounds.Type: GrantFiled: December 17, 2008Date of Patent: November 29, 2016Assignee: ACTELION PHARMACEUTICALS LTD.Inventors: Christian Hubschwerlen, Georg Rueedi, Jean-Philippe Surivet, Cornelia Zumbrunn Acklin
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Publication number: 20160237088Abstract: The invention relates to compounds of formula I wherein “” is a bond or is absent, V is CH, CR6 or N; R0 is H or, if “” is a bond, may also be alkoxy; R1 is H or halogen; U is CH or N when “” is a bond, or, if “” is absent, U is CH2, NH or NRg; R2 is H, alkylcarbonyl or —CH2—R3; R3 is H, alkyl or hydroxyalkyl; R4 is H or, if n is not 0 and R5 is H, may also be OH; R5 is H, alkyl, hydroxyalkyl, aminoalkyl, alkoxyalkyl, carboxy or alkoxycarbonyl; R6 is hydroxyalkyl, carboxy, alkoxycarbonyl or —(CH2)q—NR7R8, q being 1, 2 or 3 and each of R7 and R8 independently being H or alkyl or R7 and R8 forming with the N atom bearing them a ring; R9 is alkyl or hydroxyalkyl; A is —(CH2)p—, —CH2CH2CH(OH)— or —COCH2CH(OH)—; G is substituted phenyl or G1 or G2 wherein Q is O or S and X is CH or N; and Y1, Y2 and Y3 may each be CH or N; and n is 0 when A is —CH2CH2CH(OH)— or —COCH2CH(OH)—, and n is 0, 1 or 2 when A is —(CH2)p—, p being 1, 2, 3 or 4, with the proviso that the sum of n and p is then 2, 3 or 4; and to saltType: ApplicationFiled: April 21, 2016Publication date: August 18, 2016Inventors: Christian HUBSCHWERLEN, Daniel RITZ, Georg RUEEDI, Jean-Philippe SURIVET, Cornelia ZUMBRUNN-ACKLIN