Patents by Inventor Jean-Pierre Bali

Jean-Pierre Bali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6759204
    Abstract: The invention concerns a method for early diagnosis of cancer in a patient which consists in identifying by any appropriate method the presence of autoantibodies directed against the Csk protein in a biological sample taken from said patient. The invention also concerns a kit for implementing said diagnostic method.
    Type: Grant
    Filed: December 15, 2000
    Date of Patent: July 6, 2004
    Assignee: Centre National de la Recherche Scientifique-CNRS
    Inventors: Christine Benistant, Heliette Chapuis, Nicolas Mottet-Auselo, Serge Roche, Jean-François Bourgaux, Jean-Pierre Bali
  • Publication number: 20010005582
    Abstract: The invention concerns a method for early diagnosis of cancer in a patient which consists in identifying by any appropriate method the presence of autoantibodies directed against the Csk protein in a biological sample taken from said patient. The invention also concerns a kit for implementing said diagnostic method.
    Type: Application
    Filed: December 15, 2000
    Publication date: June 28, 2001
    Inventors: Christine Benistant, Heliette Chapuis, Nicolas Mottet-Auselo, Serge Roche, Jean-Francois Bourgaux, Jean-Pierre Bali
  • Patent number: 5091415
    Abstract: Formamidine compounds of general formula I ##STR1## in which: R.sub.1 represents H or C.sub.1-4 alkyl,R.sub.2 represents benzoyl, benzyl, or alpha-hydroxybenzyl, the aromatic ring being optionally substituted by a halogen atom,R.sub.3 and R.sub.4, which are identical or different, represent hydrogen, lower-alkyl, or lower-alkenyl, or form between them with the formamidine function a heterocycle,R.sub.5 represents hydrogen or C.sub.1-4 lower-alkyl or forms with R.sub.4 a double bond (--N.dbd.R.sub.4) in the case of pseudoaromatic heterocycles,n equals 0 or 1,A represents a linear or branched C.sub.1-4 alkylene chain,X represents hydrogen, halogen, C.sub.1-4 lower-alkyl, C.sub.1-4 lower-alkoxy, or nitro, and pharmaceutically-acceptable salts thereof, are disclosed.The compounds and pharmaceutical compositions thereof are used, optionally in combination with other active principles, as drugs for the treatment of gastrointestinal ailments, especially as gastric antisecretory and antiulcer agents.
    Type: Grant
    Filed: October 15, 1990
    Date of Patent: February 25, 1992
    Assignee: Pierre Fabre Medicament
    Inventors: Jean F. Patoiseau, Jean-Marie Autin, Henri Cousse, Veronique Sales, Jacky Tisne-Versailles, Jean-Pierre Bali
  • Patent number: 5025015
    Abstract: Formamidine compounds of general formula I ##STR1## in which: R.sub.1 represents H or C.sub.1-4 alkyl,R.sub.2 represents benzoyl, benzyl, or alphahydroxybenzyl, the aromatic ring being optionally substituted by a halogen atom,R.sub.3 and R.sub.4, which are identical or different, represent hydrogen, lower-alkyl, or lower-alkenyl, or form between them with the formamidine function a heterocycle,R.sub.5 represents hydrogen or C.sub.1-4 lower-alkyl or forms with R.sub.4 a double bond (--N.dbd.R.sub.4) in the case of pseudoaromatic heterocycles,n equals 0 or 1,A represents a linear or branched C.sub.1-4 alkylene chain,X represents hydrogen, halogen, C.sub.1-4 lower-alkyl, C.sub.1-4 lower-alkoxy, or nitro, and pharmaceutically-acceptable salts thereof, are disclosed.The compounds and pharmaceutical compositions thereof are used, optionally in combination with other active principles, as drugs for the treatment of gastrointestinal ailments, especially as gastric antisecretory and antiulcer agents.
    Type: Grant
    Filed: September 7, 1989
    Date of Patent: June 18, 1991
    Assignee: Pierre Fabre Medicament
    Inventors: Jean F. Patoiseau, Jean-Marie Autin, Henri Cousse, Veronique Sales, Jacky Tisne-Versailles, Jean-Pierre Bali
  • Patent number: 4687759
    Abstract: The invention relates to the peptides of the formula: ##STR1## in which: R represents hydrogen or a protecting group for the terminal amine group, such as t-butoxycarbonyl (Boc), benzyloxycarbonyl (Z) or lower alkanoyl;X.sub.1 represents either beta-Ala or a direct bond between R and the terminal amine group of the amino acid TRP;TRP denotes either the L isomer or the D isomer of tryptophan;X.sub.2 represents L-leucine, L-methionine or L-norleucine; andY denotes hydrogen, a halogen atom (preferably fluorine or chlorine), a trifluoromethyl group, a cyano group or a nitro group.These peptides inhibit gastric secretion.
    Type: Grant
    Filed: December 16, 1985
    Date of Patent: August 18, 1987
    Assignees: Sanofi, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Jean Martinez, Jean-Pierre Bali, Richard Magous, Bertrand Castro, Henri Demarne
  • Patent number: 4687760
    Abstract: The invention relates to the peptides of the formula: ##STR1## in which: R.sub.1 represents hydrogen or a protecting group for the amine group, such as t-butoxycarbonyl, benzyloxycarbonyl or lower alkanoyl groups;X represents beta-alanine glycine or a direct bond between R.sub.1 and the amine group; andR.sub.2 represents a group chosen from: ##STR2## corresponding to the side chains of the natural amino acid leucine, methionine and norleucine.These peptides inhibit gastric secretion.
    Type: Grant
    Filed: December 16, 1985
    Date of Patent: August 18, 1987
    Assignees: Sanofi, Centre National de la Recherche Scientifque (CNRS)
    Inventors: Jean Martinez, Jean-Pierre Bali, Richard Magous, Bertrand Castro, Henri Demarne
  • Patent number: 4636490
    Abstract: The invention relates to peptides of general formula:R--A--Gly--Trp--B--Asp--NH.sub.2 (I)in which:Asp NH.sub.2 represents the amide in .alpha. position of the aspartic acid of formula: ##STR1## R represents hydrogen, a protector group of the terminal amine function such as t.butyloxy carbonyl (BOC), benzyloxy carbonyl (Z), lower alkanoyl,A designates:either tyrosine, tyrosine-O-sulfate, threonine or methionine;or a dipeptide selected from: --Ala--TYR--, --TYR--Thr--, --TYR Met--, TYR designating either of the 2 amino-acids tyrosine or tyrosine-O-sulfate;or a tripeptide selected from: --Glu--Ala--TYR--, Asp--TYR--Thr--, --Asp--TYR--MET--;or a tetrapeptide selected from: --Glu--Glu--Ala--TYR--, --Gln Asp--TYR--Thr--, --Arg--ASP--TYR--Met--;or a pentapeptide selected from: --Glu--Glu--Glu--Ala--TYR--, --Pyr--Gln--Asp--TYR--Thr--, --Asp--Arg--Asp--TYR--Met;B designates methionine, leucine or norleucine.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: January 13, 1987
    Assignees: Sanofi, Centre National de la Recherche Scientifique
    Inventors: Jean Martinez, Jean-Pierre Bali, Bertrand Castro, Dino Nisato, Henri Demarne