Abstract: The invention concerns a plastic package, having a content capable of being sterilised at high temperature, said package comprising at least a fluid communication member (16) between the inside and the outside of said package consisting of at least a frame circumscribing an opening and an inner seal (18) closing the opening, and whereof the peripheral edge (18a, 22a) is continuously linked to said frame, said inner seal including, a selectively sealing material sheet whereof the cutoff threshold from outside inwards, stops contaminating particles and allows through the thermal sterilising fluid, said selectively sealing material being deformable in the plane of said sheet at said high temperature.

Abstract: This connecting device applies to a sealed connection device in which, firstly, each chamber, respectively a stationary chamber “A” and a transportable chamber “B” has at least one access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing elements (12, 14), one (2) of the two doors being articulated to its flange (4), and secondly, the two doors (2, 3) have an element to lock their respective flanges (4, 5) and complementary connecting elements which allow them to be connected thereby forming, through contact of sealing elements (12, 16), an internal space “C” isolating their faces (17, 18) opposite each other from the external medium.

Abstract: A sealed connection device in which, two chambers (“A” and “B”), each has an access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing means (12, 14), one (2) of the two doors being articulated with its flange (4). The detection device comprises two grooves (30, 35), formed in the external face of the flange (4) of chamber (A), a seal (36) placed in the groove (35), a network of ducts (31, 32, 33) formed in flange (4) and connecting the inner groove (30) to a coupling (34), a vacuum pump (38) the intake (37) of which is connected to the said coupling, and a sensor (44) measuring the strength of the partial vacuum in the pneumatic circuit leading to the groove (30) and reacting on alarm means (47, 48) if ever the partial vacuum does not reach an appropriate value.

Abstract: A process for the external decontamination of a packaged object, the latter comprising the object proper, at least the external surface of which is in the decontaminated state, for example sterile, a closed wrapper containing said object, the interior of which is in the decontaminated state, for example sterile, as well as a means of filtration, said process comprising a step of decontaminating the external surface of the wrapper, wherein, before the step of decontaminating the external surface of the wrapper: a) at least two parts and are formed in the wrapper, these respectively determining two compartments and which are leaktight with respect to one another, a first part containing said object, and a second part comprising the whole of the filtration means; b) the second part is separated from the first part, while preserving the leaktightness of the first compartment; then the first part alone is subjected to the step of decontaminating the external surface of the wrapper.

Abstract: A method for surface marking a solid substrate (1), according to which, during an exposure sequence, said substrate is exposed to coherent monochromatic light (2) in order to strip said substrate over an indented surface (3), wherein the exposure conditions, including duration, are set in order to restrict said indented surface to simple abrasion designed for the bonding of a printing medium, and the exposure sequence is followed by a sequence of projecting in discrete form, during which particles (6) of said printing medium, the deposition of which subsequently defines a printed element (4), are projected in targeted fashion into the indented surface (3, 31).

Abstract: A drug delivery system for administering preset doses of a substance such as a drug, vaccine or the like is provided. The drug delivery system includes a holder and a pre-filled drug container such as a syringe which is securely retained in the holder. The drug container includes a barrel for containing the substance, a movable stopper situated within the barrel, and a blunt end having an opening through which the substance within the barrel can be expelled. The holder includes a distal portion and a proximal portion, each configured to accommodate the drug container, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the delivery system.

Abstract: A sealed connection device in which, two chambers (“A” and “B”), each has an access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing means (12, 14), one (2) of the two doors being articulated with its flange (4). The detection device comprises two grooves (30, 35), formed in the external face of the flange (4) of chamber (A), a seal (36) placed in the groove (35), a network of ducts (31, 32, 33) formed in flange (4) and connecting the inner groove (30) to a coupling (34), a vacuum pump (38) the intake (37) of which is connected to the said coupling, and a sensor (44) measuring the strength of the partial vacuum in the pneumatic circuit leading to the groove (30) and reacting on alarm means (47, 48) if ever the partial vacuum does not reach an appropriate value.

Abstract: A method for surface marking a solid substrate (1), according to which, during an exposures sequence, said substrate is exposed to coherent monochromatic light (2) in order to strip said substrate over an indented surface (3), wherein the exposure conditions, including duration, are set in order to restrict said indented surface to simple abrasion designed for the bonding of a printing medium, and the exposure sequence is followed by a sequence of projecting in discrete form, during which particles (6) of said printing medium, the deposition of which subsequently defines a printing element (4), are projected in targeted fashion into the indented surface (3, 31). A device for marking a surface of a substrate is also provided.

Abstract: A drug delivery system for administering preset doses of a substance such as a drug, vaccine or the like is provided. The drug delivery system includes a holder and a pre-filled drug container such as a syringe which is securely retained in the holder. The drug container includes a barrel for containing the substance, a movable stopper situated within the barrel, and a blunt end having an opening through which the substance within the barrel can be expelled. The holder includes a distal portion and a proximal portion, each configured to accommodate the drug container, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the delivery system.

Abstract: Connection device for medical use of the Luer-lock type, comprising:

Abstract: A sealed connection device in which, two chambers (“A” and “B”), each has an access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing means (12, 14), one (2) of the two doors being articulated with its flange (4). The detection device comprises two grooves (30, 35), formed in the external face of the flange (4) of chamber (A), a seal (36) placed in the groove (35), a network of ducts (31, 32, 33) formed in flange (4) and connecting the inner groove (30) to a coupling (34), a vacuum pump (38) the intake (37) of which is connected to the said coupling, and a sensor (44) measuring the strength of the partial vacuum in the pneumatic circuit leading to the groove (30) and reacting on alarm means (47, 48) if ever the partial vacuum does not reach an appropriate value.

Abstract: This connecting device applies to a sealed connection device in which, firstly, each chamber, respectively a stationary chamber “A” and a transportable chamber “B” has at least one access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing means (12, 14), one (2) of the two doors being articulated to its flange (4), and secondly, the two doors (2, 3) have means of locking to their respective flanges (4, 5) and complementary connecting means which allow them to be connected thereby forming, through contact of sealing means (12, 16), an internal space “C” isolating their faces (17, 18) opposite each other from the external medium.

Abstract: This connecting device applies to a sealed connection device in which, firstly, each chamber, respectively a stationary chamber “A” and a transportable chamber “B” has at least one access opening equipped with a door (2, 3) cooperating with a flange (4, 5) with the interposition of sealing elements (12, 14), one (2) of the two doors being articulated to its flange (4), and secondly, the two doors (2, 3) have an element to lock their respective flanges (4, 5) and complementary connecting elements which allow them to be connected thereby forming, through contact of sealing elements (12, 16), an internal space “C” isolating their faces (17, 18) opposite each other from the external medium.

Abstract: Leaktight confinement appliance (1), intended to cooperate with an independent receptacle (3) containing a substance (4), having its own means (8) for transfer into and/or out of the receptacle, and with an independent means (71) for delivery of a material. The appliance includes a handling chamber (2) defined by a wall (13) of flexible material substantially leaktight with respect to the external environment. A pouch is formed within the wall of the handling chamber (2) for retaining an interconnection device. The handling chamber (2) is arranged to connect at least the transfer means (8) of the receptacle (3) to the delivery means (71) through the interconnection device.

Abstract: Leaktight confinement appliance (1), intended to cooperate at least with one independent receptacle (3) containing a substance (4), having its own means (8) for transfer into and/or out of the said receptacle, and with at least one independent means (71) for delivery of a material, the said appliance comprising a handling chamber (2), defined by a wall (13) of flexible material substantially leaktight with respect to the external environment, arranged to connect at least the transfer means (8) of the receptacle (3) to the delivery means (71), inside the handling chamber (2). This appliance comprises a means for leaktight assembly (50) between the handling chamber (2) and the transfer means (8) of the receptacle (3), and a means (70) for leaktight connection between the handling chamber (2) and the delivery means (71).

Abstract: Leaktight confinement appliance (1), intended to cooperate at least with one independent receptacle (3) containing a substance (4), having its own means (8) for transfer into and/or out of the said receptacle, and with at least one independent means (71) for delivery of a material, the said appliance comprising a handling chamber (2), defined by a wall (13) of flexible material substantially leaktight with respect to the external environment, arranged to connect at least the transfer means (8) of the receptacle (3) to the delivery means (71), inside the handling chamber (2).

Abstract: A drug delivery system for administering preset doses of a substance such as a drug, vaccine or the like is provided. The drug delivery system includes a holder and a pre-filled drug container such as a syringe which is securely retained in the holder. The drug container includes a barrel for containing the substance, a movable stopper situated within the barrel, and a blunt end having an opening through which the substance within the barrel can be expelled. The holder includes a distal portion and a proximal portion, each configured to accommodate the drug container, with the distal portion being able to be assembled to the proximal portion, which acts as a plunger rod during activation of the delivery system.

Abstract: A resealable vial featuring a connector assembly having a membrane and a pusher for selectively opening or sealing the fluid passageway between the bottle and the connector end of a luer hub. The connector assembly includes a body disposed on said bottle, and means for communicating fluid such as a luer connector hub which may be separately provided with the body or formed integrally therewith. The luer connector hub features a connector end open for access by medical delivery instrument, and an opposed end which is disposed for fluid communication with a recess defined by the body. The body defines a recess having a fluid path with the open top of the bottle. A membrane, preferably formed from an elastomeric material, is secured across both the recess and the open top of the bottle, and may be retained between the top surface of the bottle and the body.

Abstract: A resealable vial featuring a fluid access device having a membrane for selectively opening or sealing a fluid passageway between the bottle and the fluid access device. The vial includes a body disposed on said bottle. The fluid access device can be configured as a spike assembly, a needle assembly, or a luer lock assembly, and features a hollowed rod in sliding, fluid-tight relation to an orifice defined by the body. A membrane, preferably formed from an elastomeric material, is secured across both the orifice and the open top of the bottle, and may be retained between the top surface of the bottle and the body. The membrane preferably includes a central area sealing the orifice from the open top of the bottle, with one or more fluid passages defined on a portion of the membrane outside of the central area.

Abstract: A stopper assembly having by-pass features for use in a multi-chamber syringe barrel. The stopper assembly includes a sequential stopper body responsive to fluid forces for enabling the sequential delivery of disparate contents, such as disparate fluids, separately held in the syringe barrel. The sequential stopper body has a generally cylindrical sidewall with a distal end, a proximal end and a longitudinal axis therethrough. The stopper assembly also includes a generally cylindrical flow channelizer mounted to the distal end of the sequential stopper body. The flow channelizer enables the reconstitution of dry medicament held in the syringe barrel distally of the flow channelizer. The flow channelizer features opposed proximal and distal ends and a generally cylindrical outer surface therebetween. At least one fluid flow channel extends between the proximal and distal ends of a flow channelizer.