Patents by Inventor Jean-Pierre Kaplan

Jean-Pierre Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Propynylamine-substituted dibenzo[b,f]thiepins and dibenz[b,f]oxepins
    Patent number: 4035386
    Abstract: Compounds of the formulas ##STR1## WHEREIN R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and X are as hereinafter set forth,Are described. The compounds of formulas I and Ia are useful as neuroleptic agents.
    Type: Grant
    Filed: August 13, 1976
    Date of Patent: July 12, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Pierre Kaplan, Emilio Kyburz
  • Dibenz[b,f]oxepin derivatives
    Patent number: 4032525
    Abstract: Dibenz[b,f]oxepins of the formula ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter described. The foregoing compounds exhibit strong central depressant and neuroleptic properties, and are useful, for example, in the treatment of acute or chronic schizophrenia and also as tranquilizers.
    Type: Grant
    Filed: December 18, 1974
    Date of Patent: June 28, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Emilio Kyburz, Jean-Pierre Kaplan
  • 2-Methoxy-benzamide derivatives
    Patent number: 4021567
    Abstract: The invention provides novel 2-methoxy-benzamide derivatives of the formula: ##STR1## in which n is 1 or 2; R.sub.1 represents a cycloalkyl-alkyl radical of formula:(CH.sub.2).sub.m -CH-A- ,a phenylalkyl radical of formula ##STR2## (in which m is an integer from 2 to 5, A is a linear or branched alkylene chain of 1 to 4 carbon atoms, and R.sub.4 is hydrogen, halogen, especially fluorine or chlorine, trifluoromethyl, or alkyl or alkoxy of 1 to 3 carbon atoms), CNCH.sub.2 -CH.sub.2 -, CH.tbd.C-CH.sub.2 -, ##STR3## R.sub.2 is either chlorine, SO.sub.2 R.sub.5 (in which R.sub.5 is alkyl of 1 to 4 carbon atoms), or SO.sub.2 NR.sub.6 R.sub.7 (in which, R.sub.6 and R.sub.7, which are identical or different, represent, independently of one another, hydrogen or alkyl of 1 to 4 carbon atoms); and R.sub.
    Type: Grant
    Filed: December 16, 1975
    Date of Patent: May 3, 1977
    Assignee: Synthelabo
    Inventors: Jean-Pierre Kaplan, Bernard Michel Raizon, Daniel Charles Leon Obitz, Philippe Michel Jacques Manoury, Henry Najer, Maurice Jalfre, Don Pierre Rene Lucien Giudicelli
  • Fluoro-substituted dibenzo[b,f]thiepins
    Patent number: 4011222
    Abstract: Compounds of the formulas ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n are as hereinafter set forth, are described. The compounds of formulas I and Ia are prepared inter alia by the reaction of the corresponding dibenzo[b,f] thiepin and the corresponding piperazine compound. The end products are useful as neuroleptic agents.
    Type: Grant
    Filed: January 12, 1976
    Date of Patent: March 8, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz
  • 10,11-Dihydro dibenzo(b,f)thiepin derivatives
    Patent number: 4006145
    Abstract: Dibenzothiepin derivatives of the general formula ##STR1## wherein m, n, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter set forth, and salts thereof as well as processes for their manufacture are disclosed. The end products are useful as central-depressant and neuroleptic agents.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: February 1, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz
  • 10,11-Dihydro-dibenzo(b,f)thiepin derivatives
    Patent number: 4006144
    Abstract: Dibenzothiepin derivatives of the general formula ##STR1## wherein m, n, R.sub.1, R.sub.2, R.sub.3 and X are as hereinafter set forth,And salts thereof as well as processes for their manufacture are disclosed. The end products are useful as central-depressant and neuroleptic agents.
    Type: Grant
    Filed: October 3, 1975
    Date of Patent: February 1, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz
  • Substituted 10-ethynyldibenzo[b,f]thiepins and dibenz[b,f]oxepins
    Patent number: 4005105
    Abstract: Compounds of the formulas ##STR1## WHEREIN R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and X are as hereinafter set forth,Are described. The compounds of formulas I and Ia are useful as neuroleptic agents.
    Type: Grant
    Filed: September 15, 1975
    Date of Patent: January 25, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jean-Pierre Kaplan, Emilio Kyburz
  • 1-[10,11-Dihydro-dibenzo[b,f]-thiepin-10-yl]-4-(alkynylalkyl)-piperazines
    Patent number: 3996229
    Abstract: Dibenzo[b,f]thiepin derivatives of the formula ##SPC1##Wherein R, R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as hereinafter set forth, are described. The dibenzo[b,f]thiepins of the invention possess strong central depressant and neuroleptic properties and are therefore useful, for example, in the treatment of acute or chronic schizophrenia and also as tranquilizers.
    Type: Grant
    Filed: January 8, 1975
    Date of Patent: December 7, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz
  • Fluoro-substituted dibenso[b,f] thiepins
    Patent number: 3966737
    Abstract: Compounds of the formulas ##SPC1##Wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n are as hereinafter set forth,Are described. The compounds of formulas I and Ia are prepared inter alia by the reaction of the corresponding dibenzo[b,f] thiepin and the corresponding piperazine compound. The end products are useful as neuroleptic agents.
    Type: Grant
    Filed: May 17, 1974
    Date of Patent: June 29, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz
  • Dibenzo[b,f]thiepins
    Patent number: 3954769
    Abstract: Compounds of the formulas ##SPC1##Wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4 and n are as hereinafter set forth,Are described. The compounds of formulas I and Ia are prepared inter alia by reacting the corresponding dibenzo[b,f]thiepin and the corresponding piperazine compound. The end products are useful as neuroleptic agents.
    Type: Grant
    Filed: May 17, 1974
    Date of Patent: May 4, 1976
    Assignee: Hoffman-La Roche Inc.
    Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz
  • Dibenzo [b,f]thiepins bearing piperazinyl substitution
    Patent number: 3954764
    Abstract: Compounds of the formulas ##SPC1##Wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, m and n and X are as hereinafter set forth,Are described. The compounds of formulas I and Ia are useful as neuroleptic agents.
    Type: Grant
    Filed: May 17, 1974
    Date of Patent: May 4, 1976
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Max Gerecke, Jean-Pierre Kaplan, Emilio Kyburz