Patents by Inventor Jean-Pierre Lecouve

Jean-Pierre Lecouve has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Process for the synthesis of 7-methoxy-naphthalene-1-carbaldehyde and application in the synthesis of agomelatine

Patent number: 9701608

Abstract: Process for the industrial synthesis of the compound of formula (I):

Type: Grant

Filed: December 4, 2014

Date of Patent: July 11, 2017

Assignee: LES LABORATORIES SERVIER

Inventors: Jean-Françoís Briere, Raphaël Lebeuf, Vincent Levacher, Christophe Hardouin, Jean-Pierre Lecouve
Process for the synthesis of agomelatine

Patent number: 9604911

Abstract: Process for the industrial synthesis of the compound of formula (I):

Type: Grant

Filed: December 4, 2014

Date of Patent: March 28, 2017

Assignee: LES LABORATOIRES SERVIER

Inventors: Jean-François Briere, Raphaël Lebeuf, Vincent Levacher, Christophe Hardouin, Jean-Pierre Lecouve
PROCESS FOR THE SYNTHESIS OF AGOMELATINE

Publication number: 20160368859

Abstract: Process for the industrial synthesis of the compound of formula (I):

Type: Application

Filed: December 4, 2014

Publication date: December 22, 2016

Inventors: Jean-François BRIERE, Raphaël LEBEUF, Vincent LEVACHER, Christophe HARDOUIN, Jean-Pierre LECOUVE
PROCESS FOR THE SYNTHESIS OF 7-METHOXY-NAPHTHALENE-1-CARBALDEHYDE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE

Publication number: 20160304429

Abstract: Process for the industrial synthesis of the compound of formula (I):

Type: Application

Filed: December 4, 2014

Publication date: October 20, 2016

Inventors: Jean-François BRIERE, Raphaël LEBEUF, Vincent LEVACHER, Christophe HARDOUIN, Jean-Pierre LECOUVE
Synthesis process, and crystalline form of 4-{3-[-hexahydrocyclopenta[]pyrrol-2(1)-yl]propoxy} benzamide hydrochloride and pharmaceutical compositions containing it

Patent number: 8952179

Abstract: Industrial synthesis process for the compound of formula (I):

Type: Grant

Filed: December 11, 2013

Date of Patent: February 10, 2015

Assignee: Les Laboratories Servier

Inventors: Nicolas Robert, Jean-Michel Lerestif, Jean-Pierre Lecouve, Marina Gaillard, Loic Meunier, Philippe Letellier, Mathieu Boiret
Process for the resolution of enantiomers of (3,4 dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine

Patent number: 8927758

Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.

Type: Grant

Filed: March 26, 2013

Date of Patent: January 6, 2015

Assignee: Les Laboratories Servier

Inventors: Jean-Michel Lerestif, Jean-Pierre Lecouve, Daniel Dron, Eric Gojon, Maryse Phan
Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile and application in the synthesis of ivabradine

Patent number: 8778930

Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.

Type: Grant

Filed: March 26, 2013

Date of Patent: July 15, 2014

Assignee: Les Laboratories Servier

Inventors: Jean-Michel Lerestif, Jean-Pierre Lecouve, Daniel Dron, Eric Gojon, Maryse Phan
SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-{3[CIS-HEXAHYDROCYCLOPENT A[CjPYRROL-2( 1 H)-YLjPROPOXYj BENZAMI DE HYDROCHLORI DE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

Publication number: 20140155453

Abstract: Medicinal products containing the crystalline form I of the compound of formula (I): and/or crystalline form I of the associated free base which are useful in the treatment of disorders of the histaminergic system.

Type: Application

Filed: February 6, 2014

Publication date: June 5, 2014

Applicant: LES LABORATOIRES SERVIER

Inventors: Nicolas ROBERT, Jean-Michel LERESTIF, Jean-Pierre LECOUVE, Marina GAILLARD, Loic MEUNIER, Philippe LETELLIER, Mathieu BOIRET
SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4- BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

Publication number: 20140100374

Abstract: Industrial synthesis process for the compound of formula (I):

Type: Application

Filed: December 11, 2013

Publication date: April 10, 2014

Applicant: LES LABORATOIRES SERVIER

Inventors: Nicolas ROBERT, Jean-Michel Lerestif, Jean-Pierre Lecouve, Marina Gaillard, Loic Meunier, Philippe Letellier, Mathieu Boiret
Synthesis process, and crystalline form of 4-{3-[-hexahydrocyclopenta[]pyrrol-2(1)-yl]proxy}benzamide hydrochloride and pharmaceutical compositions containing it

Patent number: 8664408

Abstract: Industrial synthesis process for, and crystalline form I of, the compound of formula (I): and also crystalline form I of the associated free base. Medicinal products containing the same which are useful in the treatment of disorders of the histaminergic system.

Type: Grant

Filed: June 6, 2012

Date of Patent: March 4, 2014

Assignee: Les Laboratoires Servier

Inventors: Nicolas Robert, Jean-Michel Lerestif, Jean-Pierre Lecouve, Marina Gaillard, Philippe Letellier, Mathieu Boiret, Julie Meunier
Process for the resolution of enantiomers of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl) nitrile and application in the synthesis of ivabradine

Patent number: 8536365

Abstract: Process for the optical resolution of the compound of formula (I): by chiral chromatography. Application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.

Type: Grant

Filed: August 24, 2009

Date of Patent: September 17, 2013

Assignee: Les Laboratoires Servier

Inventors: Jean-Michel Lerestif, Jean-Pierre Lecouve, Daniel Dron, Eric Gojon, Maryse Phan
Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Patent number: 8513410

Abstract: Process for the synthesis of ivabradine of formula (I): addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.

Type: Grant

Filed: November 9, 2012

Date of Patent: August 20, 2013

Assignee: Les Laboratoires Servier

Inventors: Jean-Luc Renaud, Nicolas Pannetier, Jean-Pierre Lecouve, Lucile Vaysse-Ludot, Solenne Moulin
Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Patent number: 8507668

Abstract: Process for the synthesis of ivabradine of formula (I): addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.

Type: Grant

Filed: December 14, 2012

Date of Patent: August 13, 2013

Assignee: Les Laboratoires Servier

Inventors: Jean-Luc Renaud, Nicolas Pannetier, Sylvain Gaillard, Jean-Pierre Lecouve, Lucile Vaysse-Ludot
PROCESS FOR THE SYNTHESIS OF IVABRADINE AND ADDITION SALTS THEREOF WITH A PHARMACEUTICALLY ACCEPTABLE ACID

Publication number: 20130158256

Abstract: Process for the synthesis of ivabradine of formula (I): addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.

Type: Application

Filed: November 9, 2012

Publication date: June 20, 2013

Applicant: LES LABORATOIRES SERVIER

Inventors: Jean-Luc RENAUD, Nicolas Pannetier, Jean-Pierre Lecouve, Lucile Vaysse-Ludot, Solenne Moulin
Process for the synthesis of (7-methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine

Patent number: 8436206

Abstract: Process for the industrial synthesis of the compound of formula (I) Application of such process in the synthesis of agomelatine.

Type: Grant

Filed: July 30, 2012

Date of Patent: May 7, 2013

Assignee: Les Laboratoires Servier

Inventors: Thierry DuBuffet, Jean-Pierre Lecouve, Jean-Paul Hermet
Process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

Patent number: 8415468

Abstract: Process for the synthesis of ivabradine of formula (I): and addition salts thereof with a pharmaceutically acceptable acid.

Type: Grant

Filed: February 3, 2010

Date of Patent: April 9, 2013

Assignee: Les Laboratoires Servier

Inventors: Jean-Louis Peglion, Aimee Dessinges, Bernard Serkiz, Jean-Michel Lerestif, Jean-Pierre Lecouve
PROCESS FOR THE SYNTHESIS OF (7-METHOXY-1-NAPHTHYL) ACETONITRILE AND APPLICATION IN THE SYNTHESIS OF AGOMELATINE

Publication number: 20120330062

Abstract: Process for the industrial synthesis of the compound of formula (I) Application of such process in the synthesis of agomelatine.

Type: Application

Filed: July 30, 2012

Publication date: December 27, 2012

Applicant: LES LABORATOIRES SERVIER

Inventors: Thierry Dubuffet, Jean-Pierre Lecouve, Jean-Paul Hermet
SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT

Publication number: 20120316214

Abstract: Industrial synthesis process for, and crystalline form I of, the compound of formula (I): and also crystalline form I of the associated free base. Medicinal products containing the same which are useful in the treatment of disorders of the histaminergic system.

Type: Application

Filed: June 6, 2012

Publication date: December 13, 2012

Applicant: LES LABORATOIRES SERVIER

Inventors: Nicolas ROBERT, Jean-Michel LERESTIF, Jean-Pierre LECOUVE, Marina GAILLARD, Loïc MEUNIER, Philippe LETELLIER, Mathieu BOIRET, Julie Meunier
PROCESS FOR THE SYNTHESIS OF AGOMELATINE

Publication number: 20120245363

Abstract: Process for the industrial synthesis of the compound of formula (I)

Type: Application

Filed: June 1, 2012

Publication date: September 27, 2012

Applicant: LES LABORATOIRES SERVIER

Inventors: Christophe HARDOUIN, Jean-Pierre LECOUVE, Nicolas BRAGNIER
Process for the synthesis of (methoxy-1-naphthyl) acetonitrile and application in the synthesis of agomelatine

Patent number: 8252951

Abstract: Process for the industrial synthesis of the compound of formula (I) Application of such process in the synthesis of agomelatine.

Type: Grant

Filed: August 1, 2008

Date of Patent: August 28, 2012

Assignee: Les Laboratoires Servier

Inventors: Thierry Dubuffet, Jean-Pierre Lecouve, Jean-Paul Hermet

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