Patents by Inventor Jean-Pierre Rabes

Jean-Pierre Rabes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for detecting the presence of or predisposition to autosomal dominant hypercholesterolemia
    Patent number: 7300754
    Abstract: The present invention discloses the identification of a human hypercholesterolemia causal gene, which can be used for the diagnosis, prevention and treatment of hypercholesterolemia, more particularly familial hypercholesterolemia, as well as for the screening of therapeutically active drugs. The invention more specifically disclosed that mutations in the PCSK9 gene encoding NARC-1 causes autosomal dominant hypercholesterolemia and represent novel targets for therapeutic intervention. The invention can be used in the diagnosis of predisposition to, detection, prevention and/or treatment of coronary heart disease and, cholesterol, lipid and lipoprotein metabolism disorders, including familial hypercholesterolemia, atherogenic dyslipidemia, atherosclerosis, cardiovascular diseases.
    Type: Grant
    Filed: April 23, 2004
    Date of Patent: November 27, 2007
    Assignee: Institut National de la Sante et de la Recherche Medicale
    Inventors: Marianne Abi Fadel, Catherine Boileau, Jean-Pierre Rabes, Nabil G. Seidah, Mathilde Varret
  • Human hypercholesterolemia causal gene and use thereof
    Publication number: 20040248177
    Abstract: The present invention discloses the identification of a human hypercholesterolemia causal gene, which can be used for the diagnosis, prevention and treatment of hypercholesterolemia, more particularly familial hypercholesterolemia, as well as for the screening of therapeutically active drugs. The invention more specifically disclosed that mutations in the PCSK9 gene encoding NARC-1 causes autosomal dominant hypercholesterolemia and represent novel targets for therapeutic intervention. The invention can be used in the diagnosis of predisposition to, detection, prevention and/or treatment of coronary heart disease and, cholesterol, lipid and lipoprotein metabolism disorders, including familial hypercholesterolemia, atherogenic dyslipidemia, atherosclerosis, cardiovascular diseases.
    Type: Application
    Filed: April 23, 2004
    Publication date: December 9, 2004
    Inventors: Marianne Abi Fadel, Catherine Boileau, Jean-Pierre Rabes, Nabil G. Seidah, Mathilde Varret