Abstract: A microparticle for drug delivery comprises an active agent and an excipient, the excipient comprising a metal ion-lipid complex. The metal ion is chosen from the group consisting of lanthanide metals, actinide metals, group IIa and IIIb metals, transition metals or mixtures thereof. The lipid comprises a phospholipid. The complex results in a glass transition temperature increase of the microparticle.

Abstract: Microparticle compositions comprising metal ion-lipid complexes for drug delivery are described including methods of making the microparticle compositions and methods of treating certain conditions and disease states by administering the microparticle compositions. The metal ion-lipid complexes can be combined with various drugs or active agents for therapeutic administration. The microparticle compositions of the present invention have superior stability to other microparticle compositions resulting in a microparticle composition with longer shelf life and improved dispersability. The microparticle compositions of the present invention have a transition temperature (Tg) of at least 20° C. above the recommended storage temperature (Tst) for drug delivery.

Abstract: Microparticle compositions comprising metal ion-lipid complexes for drug delivery are described including methods of making the microparticle compositions and methods of treating certain conditions and disease states by administering the microparticle compositions. The metal ion-lipid complexes can be combined with various drugs or active agents for therapeutic administration. The microparticle compositions of the present invention have superior stability to other microparticle compositions resulting in a microparticle composition with longer shelf life and improved dispersability. The microparticle compositions of the present invention have a transition temperature (Tg) of at least 20° C. above the recommended storage temperature (Tst) for drug delivery.

Abstract: Microparticle compositions comprising metal ion-lipid complexes for drug delivery are described including methods of making the microparticle compositions and methods of treating certain conditions and disease states by administering the microparticle compositions. The metal ion-lipid complexes can be combined with various drugs or active agents for therapeutic administration. The microparticle compositions of the present invention have superior stability to other microparticle compositions resulting in a microparticle composition with longer shelf life and improved dispersability. The microparticle compositions of the present invention have a transition temperature Tm of at least 20° C. above the recommended storage temperature (Tst) for drug delivery.

Abstract: A method for transpulmonary cooling by providing a liquid having a boiling point of 38-300° C., more preferably 38-250° C., more preferably 38-200° C., more preferably 38-150° C., more preferably 38-80° C. The liquid is nebulized to form a mist. The mist is optionally cooled below room temperature and delivered to the airway of a patient so that the patient inhales the mist. The mist causes systemic cooling by evaporative heat loss when inhaled at room temperature and additionally by direct heat transfer when inhaled below room temperature. Compositions and medical devices for transpulmonary cooling are also provided.

Abstract: Compounds having a polyhydroxylated hydrophilic moiety, a highly fluorinated moiety and a functional junction group linking said moieties together, wherein said hydrophilic moiety is derived from a polyol or an aminopolyol, and wherein said highly fluorinated moiety consists of a fluorocarbon group wherein at lest 50% of the atoms bonded to the carbon skeleton are fluorine atoms, the other atoms bonded to the carbon skeleton being hydrogen, chlorine or bromine atoms, said highly fluorinated moiety containing at least 4 fluorine atoms; as well as the internal ethers and ketals thereof; process for their preparation; and a compositions containing said compounds as surfactants, together with non polar compounds, for use as gas carriers.

Abstract: This invention concerns new branched perfluoroalkylated ethenes, their preparation and their use, in the form of aqueous emulsions, as oxygen carriers, and in particular as blood substitutes or as perfusion agents for the preservation of organs before transplant.

Abstract: A polyfluorinated butadiene having the formula ##EQU1## wherein n and m are integers from 1 to 10 and n=m or n.noteq.m, is prepared by reductive coupling, exemplarily with copper, of the corresponding 1,2-bis(perfluoroalkyl)iodoethylene having the formula CF.sub.3 (CF.sub.2).sub.n CH = CI--(CF.sub.2).sub.m CF.sub.3. This iodoethylene is conveniently prepared by a simple addition reaction between a perfluoroalkyl iodide and a perfluoroalkyl acetylene. The perfluoralkylated butadienes are useful as transporters of dissolved gas, particularly of oxygen as in blood substitutes.

Abstract: New perfluoroalkyl derivatives of benzodiazepine are prepared by reacting an orthophenylenediamine with a beta-diketone at least one of whose alkyls is a C.sub.1 - C.sub.15 perfluoroalkyl. The stable products are useful as heat-exchange substances and as surfactants in organic solution.