Abstract: The disclosure relates to lipid-coated calcium carbonate nanoparticles, said nanoparticles comprising an outer layer and a core being calcium carbonate nanoparticle, wherein said core is vaterite, proto-vaterite, or amorphous calcium carbonate as determined by X-Ray diffraction, wherein said core is at least partially coated with one or more amphiphilic compounds each having one hydrophilic head and at least one hydrophobic tail, remarkable in that the hydrophilic heads are negatively charged and form the outer layer of the nanoparticles, in that the nanoparticles have a surface charge having a ?-potential below 0 mV as determined by micro-electrophoretic light scattering technology and in that said one or more amphiphilic compounds are PEG-free. The disclosure also relates to methods for forming such nanoparticles, for modulating the electrical charge of such nanoparticles as well as to the uses of such nanoparticles.

Abstract: The present disclosure relates to a rubber composition comprising at least rubber, and reinforcement materials, the reinforcement materials comprising silica particles and Kraft lignin nanoparticles, wherein the phr ratio between the silica particles and Kraft lignin nanoparticles is ranging between 3 and 20; wherein the Kraft lignin nanoparticles have an average diameter size ranging between 10 and 100 nm as determined by scanning electron microscopy; and wherein the Kraft lignin nanoparticles have a glass transition temperature of at least 150° C. as determined by Differential Scanning Calorimetry.

Abstract: The disclosure relates to core-shell nanoparticle, the nanoparticle comprising a core being one or more selected from vaterite, proto-vaterite, and amorphous calcium carbonate as determined by X-Ray diffraction, remarkable in that the nanoparticle further comprises a shell of polyphenol, wherein said polyphenol is selected to be insoluble in water, to show a pH ranging from 5 to 9 when measured in a solution of one or more polar solvents and water at a concentration of 10 wt. % based on the total weight of said solution and wherein said polyphenol is at least partially soluble in said one or more polar solvents. A method for forming such nanoparticle as well as their use and the use of polyphenol as shell of shell-core nanoparticle is also described.

Abstract: The disclosure relates to a method for manufacturing a colloidal dispersion of Kraft lignin (KL) nanoparticles, said method comprising the steps of (a) providing KL; (b) dissolving said KL into a solvent, to obtain a solution having a concentration of Kraft lignin of at least 15 mg/ml; and (c) mixing said solution with an antisolvent under mixing conditions, to provide a colloidal dispersion of nanoparticles. Said method is remarkable in that the solvent used in step (b) of dissolving said KL is one or more organic solvents, and in that step (c) of mixing is performed by the addition of the solution of step (b) into an antisolvent being or comprising water. The disclosure also relates to spherical KL nanoparticles with an average diameter size ranging from 9 nm up to 70 nm. The disclosure further relates to various uses of said spherical KL nanoparticle.

Abstract: A method for manufacturing supported lipid bilayer on a porous silica nanoparticle with a ?-potential comprised between ?10 mV and +10 mV, the method comprising the steps of (a) providing a negatively charged supported lipid bilayer on a porous silica nanoparticle, wherein the negatively charged supported lipid bilayer has a ?-potential inferior to ?15 mV and wherein the negatively charged supported lipid bilayer comprised at least one phospholipid and; (b) adding a formulation of lipids, the lipids being 1,2-dioleoyl-3-trimethylammonium-propane alias DOTAP, cholesterol and at least one lipid different from DOTAP and cholesterol. The method further comprises the step of (c) performing an ultra-sonication for promoting DOTAP incorporation. The method can be supplemented by the step of addition of alginate and the step of cross-linking the alginate. Also a nanocapsule and composition comprising the nanocapsule.

Abstract: A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.

Abstract: The present invention is related to an electrochemical reactor (1) and a microfluidic platform (20) comprising this reactor (1), controlling pH in a closed environment, wherein this reactor (1) comprises at least one cell (2), wherein each cell (2) containing at least one micro-well (3a) able to contain a liquid and reagents and a cap (7) to close the said cell (2) and wherein the cell (2) further comprises at least one working electrode (5) producing reversible REDOX reactions.

Abstract: A method for producing a gas sensor comprising a step of providing a substrate with two coplanar electrodes and a step of forming a ZnO nanowires network on the two electrode. The step of forming a ZnO nanowires network on the two electrodes is performed as follows: synthesizing ZnO nanowires with a liquid phase sequential growth method; dispersing the synthetized nanowires in a solvent; drop casting the solution containing the solvent and the ZnO nanowires on the electrodes; drying the solution at a temperature inferior to 85° C. Also, a gas sensor working at low temperature such as room temperature.

Abstract: A method for manufacturing supported lipid bilayer on a porous silica nanoparticle with a ?-potential comprised between ?10 mV and +10 mV, the method comprising the steps of (a) providing a negatively charged supported lipid bilayer on a porous silica nanoparticle, wherein the negatively charged supported lipid bilayer has a ?-potential inferior to ?15 mV and wherein the negatively charged supported lipid bilayer comprised at least one phospholipid and; (b) adding a formulation of lipids, the lipids being 1,2-dioleoyl-3-trimethylammonium-propane alias DOTAP, cholesterol and at least one lipid different from DOTAP and cholesterol. The method further comprises the step of (c) performing an ultra-sonication for promoting DOTAP incorporation. The method can be supplemented by the step of addition of alginate and the step of cross-linking the alginate. Also a nanocapsule and composition comprising the nanocapsule.

Abstract: A method for self-assembling a mesoporous silica nanoparticle. The method comprises the step of condensing a silica precursor, a surfactant and a condensation agent in a solvent. Then, the addition of an organotriethoxysilane is performed. Finally, there is the step of removing the surfactant. The method is remarkable in that the portion of the organotriethoxysilane to the silica precursor is comprised between 5% and 15%. Additionally, a self-assembled mesoporous silica nanoparticle comprising at least one silica precursor and an organotriethoxysilane.

Abstract: The present invention is related to an electrochemical reactor (1) and a microfluidic platform (20) comprising this reactor (1), controlling pH in a closed environment, wherein this reactor (1) comprises at least one cell (2), wherein each cell (2) containing at least one micro-well (3a) able to contain a liquid and reagents and a cap (7) to close the said cell (2) and wherein the cell (2) further comprises at least one working electrode (5) producing reversible REDOX reactions.

Abstract: A method for self-assembling a mesoporous silica nanoparticle. The method comprises the step of condensing a silica precursor, a surfactant and a condensation agent in a solvent. Then, the addition of an organotriethoxysilane is performed. Finally, there is the step of removing the surfactant. The method is remarkable in that the portion of the organotriethoxysilane to the silica precursor is comprised between 5% and 15%. Additionally, a self-assembled mesoporous silica nanoparticle comprising at least one silica precursor and an organotriethoxysilane.

Abstract: A method for manufacturing a negatively charged supported lipid bilayer. The method comprises the steps of preparing a formulation comprising at least three lipids (1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS), cholesterol and at least one lipid different from DOPS and cholesterol) dissolved in a first solvent, of evaporating the first solvent, of adding an aqueous formulation of mesoporous silica nanoparticles, of performing an ultra-sonication and of performing a centrifugation. The method is remarkable in that the number of equivalents of cholesterol relative to one equivalent of DOPS is comprised between 2.30 and 2.70. Additionally, negatively charged supported lipid bilayer on a mesoporous silica nanoparticle comprising cholesterol, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine (DOPS) and at least one lipid different from DOPS and cholesterol.

Abstract: According to the present invention, an implantable device is provided, comprising a substrate on which at least one surface portion is provided. The chemical composition of the surface portion selectively enhances the cell-adhesion to the substrate.

Abstract: According to the present invention, an implantable device comprising an electrode for carrying an electric signal to or from a biological cell or tissue provided. The electrode material is chosen to exhibit desirable properties in terms of electrical conductivity, biocompatibility and bio-fouling. The invention further provides implantable devices comprising such implantable electrodes.

Abstract: A material including a continuous aqueous phase and a dispersed phase in the form of droplets containing an amphiphilic lipid and a surfactant having the following formula (I): (L1-X1—H1—Y1)v-G-(Y2—H2—X2-L2)w??(I), wherein: L1 and L2 independently represent lipophilic groups, X1, X2, Y1, Y2 and G independently represent a linking group, H1 and H2 independently represent hydrophilic groups including a polyalkoxylated chain, v and w are independently an integer from 1 to 8, wherein the droplets of the dispersed phase are covalently bonded by the surfactant having the formula (I). The invention also relating to the method for preparing the same and to the uses thereof.

Abstract: A material including a continuous aqueous phase and a dispersed phase in the form of droplets containing an amphiphilic lipid and a surfactant having the following formula (I): (L1-X1—H1—Y1)v-G-(Y2—H2—X2-L2)w ??(I), wherein: L1 and L2 independently represent lipophilic groups, X1, X2, Y1, Y2 and G independently represent a linking group, H1 and H2 independently represent hydrophilic groups including a polyalkoxylated chain, v and w are independently an integer from 1 to 8, wherein the droplets of the dispersed phase are covalently bonded by the surfactant having the formula (I). The invention also relating to the method for preparing the same and to the uses thereof.

Abstract: The present invention relates to a new class of cationic polymers that self-assemble with a pH-sensitive dissolution switch, and their uses to deliver molecules of interest to a cell. The present invention also relates to compositions comprising said cationic polymers non-covalently associated with a molecule of interest, in particular with a siRNA.

Abstract: The present invention relates to a new class of cationic polymers that self-assemble with a pH-sensitive dissolution switch, and their uses to deliver molecules of interest to a cell. The present invention also relates to compositions comprising said cationic polymers non-covalently associated with a molecule of interest, in particular with a siRNA.