Patents by Inventor Jean-Sebastien Silvestre

Jean-Sebastien Silvestre has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9138461
    Abstract: Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: September 22, 2015
    Assignees: Biogen MA Inc., INSERM (Institut National de la Santé et de la Recherche Médicale)
    Inventors: Anthony Rossomando, Jean-Sebastien Silvestre, Radia Tamarat
  • Patent number: 8916144
    Abstract: The invention relates to novel proangiogenic compositions, to the method for preparing same, and to the uses thereof, particularly for preventing or treating any disease causing ischemic-type complications.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: December 23, 2014
    Assignees: Institut des Vaisseaux et du Sang, Universite Paris Diderot Paris—7
    Inventors: Gérard Tobelem, Jean-Sébastien Silvestre
  • Publication number: 20130237477
    Abstract: Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.
    Type: Application
    Filed: November 16, 2012
    Publication date: September 12, 2013
    Applicants: INSERM (Institut de la Sante et de la Recherche Medicale), BIOGEN IDEC MA INC.
    Inventors: Anthony Rossomando, Jean-Sebastien Silvestre, Radia Tamarat
  • Publication number: 20130058916
    Abstract: The disclosure relates to an electrodynamic-transducer magnetic motor device (10) having a moving coil comprising a magnetic circuit consisting of a tied angular magnet (11), characterized in that said tied annular magnet has a hollow annular structure, said hollow annular structure comprising an annular cavity (12) connected to an upper portion (13) of an external surface (14) of said hollow annular structure by a first annular channel (15) forming a first gap in which a first winding (17) of the moving coil can move.
    Type: Application
    Filed: March 28, 2011
    Publication date: March 7, 2013
    Inventors: Gérard Tobelem, Jean-Sébastien Silvestre
  • Patent number: 8338169
    Abstract: A cell/ligand specific marking system, the system being characterized in that it comprises: (a) an endothelial precursor cell (EPC) including a cell marker selected from among the group consisting of the Eph (in particular EphB4 or EphB1), and (b) a protein material of structure L-K, which consists of a ligand (L) specific of the marker and is associated or fused with a binding protein (K), the system being capable of providing a proangiogenetic cell material of structure EPC-Eph-L-K. The invention also concerns the cell material as product capable of stimulating angiogenesis, its preparation method and its therapeutic use, in particular with respect to vascular insufficiencies.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: December 25, 2012
    Assignees: Institut des Vaisseaux et du Sang, Universite Paris 7-Denis Diderot
    Inventors: Philippe Foubert, Sophie Le Ricousse-Roussanne, Jean-Sebastien Silvestre
  • Patent number: 8329655
    Abstract: Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.
    Type: Grant
    Filed: May 1, 2008
    Date of Patent: December 11, 2012
    Assignees: Biogen Idec MA Inc., INSERM (Institut National de la Santé et de la Recherche Médicale)
    Inventors: Anthony Rossomando, Jean-Sebastien Silvestre, Radia Tamarat
  • Publication number: 20120207722
    Abstract: This invention relates to the use of cells of a medullary or extra-medullary white adipose tissue, in particular of an extra-medullary stromal vascular fraction (SVF) and/or mature dedifferentiated adipocytes of any origin for initiating the formation of a functional vascularisation.
    Type: Application
    Filed: February 8, 2012
    Publication date: August 16, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS VII (DENIS DIDEROT), UNIVERSITE PAUL SABATIER
    Inventors: Louis Casteilla, Jean-Sébastien Silvestre, Valérie Planat-Benard, Bernard Levy, Luc Penicaud, Alain Tedgui
  • Publication number: 20100261654
    Abstract: Disclosed are methods of increasing vascularization in a tissue by administering a neublastin polypeptide to a mammal exhibiting impaired or inadequate blood flow in the tissue. The methods can be used to in the treatment or prevention of a disorder characterized by impaired or inadequate blood flow or to increase vascularization in an organ that has been transplanted into a subject.
    Type: Application
    Filed: May 1, 2008
    Publication date: October 14, 2010
    Applicants: INSERM (Institut National de la Sante et de la Recherche Medicale), Biogen Idec MA Inc.
    Inventors: Anthony Rossomando, Jean-Sebastien Silvestre, Radia Tamarat
  • Publication number: 20100086524
    Abstract: The invention relates to a cellular preparation containing endothelial cell precursors (EPCs) and smooth muscular cell precursors (SMCs), as a combination product for simultaneous, separated or time-spread administration, used as a revascularisation stimulating agent. The invention also relates to the use of such a cellular preparation.
    Type: Application
    Filed: December 6, 2007
    Publication date: April 8, 2010
    Inventors: Gérard Tobelem, Sophie Le Ricousse-Roussanne, Philippe Foubert, Jean-Sébastien Silvestre
  • Publication number: 20090123431
    Abstract: A cell/ligand specific marking system, the system being characterized in that it comprises: (a) an endothelial precursor cell (EPC) including a cell marker selected from among the group consisting of the Eph (in particular EphB4 or EphB1), and (b) a protein material of structure L-K, which consists of a ligand (L) specific of the marker and is associated or fused with a binding protein (K), the system being capable of providing a proangiogenetic cell material of structure EPC-Eph-L-K. The invention also concerns the cell material as product capable of stimulating angiogenesis, its preparation method and its therapeutic use, in particular with respect to vascular insufficiencies.
    Type: Application
    Filed: July 27, 2006
    Publication date: May 14, 2009
    Inventors: Philippe Foubert, Sophie Le Ricousse-Roussanne, Jean-Sebastien Silvestre
  • Publication number: 20070116674
    Abstract: The invention relates to the use of cells of a medullary or extra-medullary white adipose tissue, in particular of an extra-medullary stromal vascular fraction (SVF) and/or mature dedifferentiated adipocytes of any origin for initiating the formation of a functional vascularisation.
    Type: Application
    Filed: September 6, 2004
    Publication date: May 24, 2007
    Inventors: Louis Casteilla, Jean-Sebastien Silvestre, Valerie Planat-Benard, Bernard Levy, Luc Penicaud, Alain Tedgui