Abstract: A liquid formulation of an ophthalmic drug in a pre-filled pharmaceutical package, for example a syringe, cartridge, vial or any other vessel made in part or in whole of a thermoplastic polymer, coated on the interior with a tie coating or layer, a barrier coating or layer, a pH protective coating or layer, and optionally a lubricity coating or layer. A blister, a pouch, a bag, a tray or a tub may encompass as a secondary packaging the syringe, vial, cartridge, tube or any other vessel. The package is suitable for sterilization (e.g., surface and/or terminal sterilization) with sterilization gas residuals being minimal and/or lower than required by ISO 10993-7; and/or the stability of the ophthalmic drug is maintained, during a prolonged time period following the sterilization. The sterilization gas may be EO, propylene oxide, chlorine dioxide, nitrogen dioxide, or vaporized hydrogen peroxide (VHP), among others.

Abstract: A method for producing a webbed fibrillar material includes providing a polymer material including a solvent; injecting the polymer material into an electric field toward an electrically charged target; controlling at least one process parameter to produce the webbed fibrillar material having one or more desired characteristics; and collecting the webbed fibrillar material from the target. The process parameter may be selected from the group consisting of an electric field strength, a temperature, a solution viscosity of the polymer material, a distance between an injection point and the target, a solvent type, a relative concentration of the solvent and polymer material, a molecular weight of the molecules of the polymer material, an environmental temperature, an environmental humidity, and a drying time of the injected polymer material.