Abstract: A computer-implemented approach for processing benefits payment claims for prescription medicine, with these operations. Receiving pending pharmacy benefits payment claims submitted for payment by a pharmacy benefits claims payor, each claim specifying a patient. For each claim and its specified patient, performing operations including the following. Performing computer-driven statistical analysis of predefined aspects of one of the following in relation to a compiled history of past claims paid by one or more pharmacy benefits claims payors: claims history for the patient, the claim, medical history of the patient. Generating an indicator of predicted legitimacy by scoring results of the statistical analysis. Providing an output of at least one of the following: the indicator, payment advice prepared by applying predefined criteria to data including the indicator.