Patents by Inventor Jean-Yves Chapelon

Jean-Yves Chapelon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10485516
    Abstract: Method for generating a shear wave in a target region of a soft solid, includes the following steps: a) generating at least two shear waves with a first and a second source of shear waves in the target region; b) detecting a propagation pattern of the shear wave in the target region with a detector unit including a row of ultrasonic transducers aligned on a first direction perpendicular to a detection direction of each or a single ultrasonic transducer movable along a first direction perpendicular to its detection direction; c) proceeding to a time reversal of the detected propagation pattern; and d) submitting the target region to an inverted excitation set of forces based on the temporally inverted propagation pattern. During step b), a first propagation pattern is detected when only the first source is active and a second propagation pattern is detected when only the second source is active.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: November 26, 2019
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Université Claude Bernard Lyon 1, Centre Léon-Bérard
    Inventors: Stefan Catheline, Remi Souchon, Ali Zorgani, Jean-Yves Chapelon
  • Patent number: 10368750
    Abstract: This shear wave imaging method, for collecting information on a target region (R) of a soft solid (S), comprises at least the steps a) of generating at least one shear wave (SW) in the target region, and b) of detecting a propagation pattern of the shear wave in the target region. Step a) is realized by applying to particles of the target region (R) some Lorentz forces resulting from an electric field (E) and from a magnetic field (B). At least one of the electric field (E) and the magnetic field (B) is variable in time, with a central frequency (fo) between 1 Hz and 10 kHz. Alternatively, both the electric and magnetic fields (E, B) are variable in time, with a central difference frequency (?fo) between 1 Hz and 10 kHz. The shear wave imaging installation comprises a first system (4, 7) for generating at least one shear wave (SW) in the target region (R) and a second system (10) for detecting a propagation pattern of the shear wave.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: August 6, 2019
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), Université Claude Bernard Lyon 1
    Inventors: Stefan Catheline, Jean-Yves Chapelon, Remi Souchon, Pol Grasland-Mongrain, Cyril Lafon
  • Publication number: 20180348168
    Abstract: This method for determining a mechanical property of a layered soft material, includes steps of a) generating an ultrasound wave (W1) focused towards a first point (P1) of the material, said wave, upon interacting with a layer of said material, generating in turn a Lamb (L1) wave propagating into said layer of the material, b) measuring, at a second point (P2) of the material belonging to said layer, a physical parameter of the generated Lamb wave, c) automatically determining the mechanical property of the layered soft material, based on the measured physical parameter. Step a) is performed by exciting a first ultrasonic transducer (401) with a first excitation signal (S401) during at most 50 ms, step b) is performed by exciting a second ultrasonic transducer (402) with a second excitation signal (S402) during at most 0.
    Type: Application
    Filed: November 25, 2016
    Publication date: December 6, 2018
    Inventors: Stefan CATHELINE, Jean-Yves CHAPELON, Cyril LAFON
  • Publication number: 20180317884
    Abstract: This device (2) for generating ultrasonic waves in a target region of a soft solid, includes at least two ultrasound sources (32), light sources (40) distributed around a central axis (X2) of the device (2), for enlightening a zone of the soft solid via subsurface scattering, and a video camera (50), for capturing images of the zone enlightened by the lighting means. The ultrasound source (32), the light sources (40) and the video camera (50) are mounted on a body of the device (20) and oriented toward a common target zone which includes a focal point of the ultrasound sources (32). A boresight of the video camera is aligned on the central axis (X2).
    Type: Application
    Filed: September 29, 2016
    Publication date: November 8, 2018
    Inventors: Jean-Yves CHAPELON, Jean-Louis MESTAS, Cyril LAFON, Bernard GREILLIER, René MILLERET
  • Publication number: 20180177519
    Abstract: The invention relates to a method for generating ultrasonic waves focused on a focal zone (5) in order to carry out biological lesions, comprising the activation of a plurality of ultrasonic transducer elements (3). According to the invention: a target zone, in which homogenization of the supply of energy of the ultrasonic waves emitted by the ultrasonic transducer elements is desired, is chosen, the focusing effect and the acoustic attenuations of the ultrasonic waves on their path between the target zone and the ultrasonic transducer elements (3) are determined, the focusing effect and the acoustic attenuations of the ultrasonic waves are compensated, with ultrasonic transducer elements (3) at least some of which have non-identical emission surfaces such that in the target zone, the supply of energy of the ultrasonic waves emitted by the different ultrasonic transducer elements (3) is more or less identical.
    Type: Application
    Filed: February 21, 2018
    Publication date: June 28, 2018
    Applicants: EDAP TMS FRANCE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Jérémy VINCENOT, David MELODELIMA, Emmanuel BLANC, Jean-Yves CHAPELON
  • Patent number: 10004922
    Abstract: The object of the invention relates to an apparatus for the thermal treatment of biological tissues by means of the application of focused ultrasound waves, the apparatus including: a probe movement system for ensuring: the moving of the focal zone along a first direction, from a distal point of the treatment zone to a proximal point of the treatment zone, in order to create a sequence of elementary treatment zones; the juxtaposition of sequences of elementary treatment zones in order to completely cover the treatment zone; a control circuit controlling the probe, in order to ensure that the ultrasonic power delivered to the focal zone decreases between the distal point and the proximal point of the treatment zone.
    Type: Grant
    Filed: October 23, 2014
    Date of Patent: June 26, 2018
    Assignees: EDAP TMS FRANCE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE-I.N.S.E.R.M.
    Inventors: Lucie Brasset, Jean-Yves Chapelon, Nicolas Guillen, Francoise Chavrier, Emmanuel Blanc
  • Patent number: 10004888
    Abstract: The method determines parameters to generate confocal ultrasound beams (B1,B2) inside a medium (4), and uses a device (1) comprising first and second ultrasound means (11,12) and first and second displacement members (13,14) for moving the ultrasound means (11,12). The parameters include signals s1,s2 to the ultrasound means (11,12), and the positions x1,x2 of the ultrasound means (11,12). The parameters are optimized for having a minimum amplitude a1,a2 of the signals s1,s2 and having an acoustic effect inside the medium (4).
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: June 26, 2018
    Assignees: INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE (INSERM), UNIVERSITE CLAUDE BERNARD, CENTRE LÉON BÉRARD
    Inventors: Jean-Yves Chapelon, Cyril Lafon, Jean-Louis Mestas
  • Patent number: 9936969
    Abstract: The invention relates to a method for generating ultrasonic waves focused on a focal zone (5) in order to carry out biological lesions, comprising the activation of a plurality of ultrasonic transducer elements (3). According to the invention: a target zone, in which homogenization of the supply of energy of the ultrasonic waves emitted by the ultrasonic transducer elements is desired, is chosen, the focusing effect and the acoustic attenuations of the ultrasonic waves on their path between the target zone and the ultrasonic transducer elements (3) are determined, the focusing effect and the acoustic attenuations of the ultrasonic waves are compensated, with ultrasonic transducer elements (3) at least some of which have non-identical emission surfaces such that in the target zone, the supply of energy of the ultrasonic waves emitted by the different ultrasonic transducer elements (3) is more or less identical.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: April 10, 2018
    Assignees: EDAP TMS FRANCE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Jeremy Vincenot, David Melodelima, Emmanuel Blanc, Jean-Yves Chapelon
  • Patent number: 9931245
    Abstract: A device for treatment of an ocular pathology characterized in that it comprises at least one eye ring (1) wherein the proximal end of said eye ring (1) is suitable to be applied onto the glove and means (2,17) to generate ultrasound beam fixed on the distal end of the eye ring (1), said means to generate ultrasound beam presenting a concave segment shape conformed along a single curvature corresponding to a single direction wherein the concavity is designed to be tuned towards the eyeglobe.
    Type: Grant
    Filed: October 14, 2016
    Date of Patent: April 3, 2018
    Assignees: Eye Tech Care, Insitut Naitonal de la Sante et de la Recherche Medicale
    Inventors: Fabrizio Romano, Cyril Lafon, Jean-Yves Chapelon, Francoise Chavrier, Alain Birer, Laurent Farcy, Philippe Chapuis
  • Publication number: 20180036558
    Abstract: An interstitial ultrasound thermal ablation applicator for conformal treatment of an inhomogeneous tumor lesion includes: a body having a longitudinal axis; and a plurality of array transducers mounted on the body, arranged side by side and having azimuth directions parallel to the longitudinal axis of the body, and having outer faces disposed in a polygonal arrangement; the plurality of array transducers having predetermined elevation dimensions defined for directing emitted ultrasonic energy to obtain a conformal volume treatment of the tumor lesions. An electronic driving method for driving an applicator having multiple independent transducer elements arranged in rows and columns includes: controlling focal parameters of each row and column of transducer elements; and controlling a contribution of each row and column of transducer elements in a manner to provide a conformal ablated volume.
    Type: Application
    Filed: October 20, 2017
    Publication date: February 8, 2018
    Inventors: Alexandre CARPENTIER, An NGUYEN-DINH, Jean-Yves CHAPELON, Rémi DUFAIT, Christophe NOTARD, Françoise CHAVRIER, Cyril LAFON, Michael CANNEY, William Apoutou N'DJIN
  • Patent number: 9737324
    Abstract: A therapeutic probe having a transducer for focusing the ultrasonic waves into a first focal area, the emission surface of which has, within a profile plane, two concave curve segments which have a finite length and which are symmetrical relative to a plane of symmetry, or to an axis of symmetry. Within the profile plane, both concave curve segments extend along arcs of first and second non-coincident circles that intersect each other, and each curve segment has an acoustic axis intersecting the axis of symmetry, or the plane of symmetry, between the first focal area and the emission surface, the acoustic axes being spaced apart from each other such that the beams from the emission surface intersect each other so as to create a second focal area located in and situated between the first focal area and the emission surface.
    Type: Grant
    Filed: March 15, 2012
    Date of Patent: August 22, 2017
    Assignees: EDAP TMS FRANCE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: David Melodelima, Jeremy Vincenot, Emmanuel Blanc, Jean-Yves Chapelon
  • Publication number: 20170027751
    Abstract: A device for treatment of an ocular pathology characterized in that it comprisesat least one eye ring (1) wherein the proximal end of said eye ring (1) is suitable to be applied onto the globe and means (2,17) to generate ultrasound beam fixed on the distal end of the eye ring (1), said means to generate ultrasound beam presenting a concave segment shape conformed along a single curvature corresponding to a single direction wherein the concavity is designed to be tuned towards the eyeglobe.
    Type: Application
    Filed: October 14, 2016
    Publication date: February 2, 2017
    Inventors: Fabrizio ROMANO, Cyril LAFON, Jean-Yves CHAPELON, Francoise CHAVRIER, Alain BIRER, Laurent FARCY, Philippe CHAPUIS
  • Publication number: 20170007206
    Abstract: Method for generating a shear wave in a target region of a soft solid, includes the following steps: a) generating at least two shear waves with a first and a second source of shear waves in the target region; b) detecting a propagation pattern of the shear wave in the target region with a detector unit including a row of ultrasonic transducers aligned on a first direction perpendicular to a detection direction of each or a single ultrasonic transducer movable along a first direction perpendicular to its detection direction; c) proceeding to a time reversal of the detected propagation pattern; and d) submitting the target region to an inverted excitation set of forces based on the temporally inverted propagation pattern. During step b), a first propagation pattern is detected when only the first source is active and a second propagation pattern is detected when only the second source is active.
    Type: Application
    Filed: February 26, 2015
    Publication date: January 12, 2017
    Inventors: Stefan CATHELINE, Remi SOUCHON, Ali ZORGANI, Jean-Yves CHAPELON
  • Publication number: 20160367143
    Abstract: This shear wave imaging method, for collecting information on a target region (R) of a soft solid (S), comprises at fi least the steps a) of generating at least one shear wave (SW) in the target region, and b) of detecting a propagation pattern of the shear wave in the target region. Step a) is realized by applying to particles of the target region (R) some Lorentz forces resulting from an electric field (E) and from a magnetic field (B). At least one of the electric field (E) and the magnetic field (B) is variable in time, with a central frequency (fo) between 1 Hz and 10 kHz. Alternatively, both the electric and magnetic fields (E, B) are variable in time, with a central difference frequency (?fo) between 1 Hz and 10 kHz. The shear wave imaging installation comprises a first system (4, 7) for generating at least one shear wave (SW) in the target region (R) and a second system (10) for detecting a propagation pattern of the shear wave.
    Type: Application
    Filed: July 10, 2014
    Publication date: December 22, 2016
    Inventors: Stefan CATHELINE, Jean-Yves CHAPELON, Rémi SOUCHON, Pol GRASLAND-MONGRAIN, Cyril LAFON
  • Patent number: 9517359
    Abstract: A device for treatment of an ocular pathology characterized in that it comprises at least one eye ring (1) wherein the proximal end of said eye ring (1) is suitable to be applied onto the globe and a generator (2,17) to generate ultrasound beam fixed on the distal end of the eye ring (1), the generator to generate ultrasound beam presenting a concave segment shape conformed along a single curvature corresponding to a single direction wherein the concavity is designed to be tuned towards the eyeglobe.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: December 13, 2016
    Assignees: EYE TECH CARE, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Fabrizio Romano, Cyril Lafon, Jean-Yves Chapelon, Françoise Chavrier, Alain Birer, Laurent Farcy, Philippe Chapuis
  • Patent number: 9403039
    Abstract: A method of treating an ocular pathology by generating high intensity focused ultrasound onto at least one eye's area, the method comprises at least the following steps of: positioning onto the eye a device capable of directing high intensity focused ultrasound onto at least one annular segment, and generating high intensity focused ultrasound energy onto the segment to treat at least one annular segment in the eye. Another embodiment of the invention concerns a device for treatment of an ocular pathology comprising at least one eye ring wherein the proximal end of the eye ring is suitable to be applied onto the globe and a high intensity focused ultrasound beam generator to generate ultrasound beam fixed on the distal end of the eye ring capable of treating the whole circumference of the eye in one step.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: August 2, 2016
    Assignees: EYE TECH CARE, INSTITUIT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Fabrizio Romano, Cyril Lafon, Jean-Yves Chapelon, Francoise Chavrier, Alain Birer
  • Publication number: 20160139123
    Abstract: The invention relates to methods comprising a step consisting of determining the proportion and/or the level of T regulatory lymphocytes with a CD4+ CD8??low Foxp3neg phenotype specific for Faecalibacterium prausnitzii for (i) diagnosing, (ii) prognosing outcome of, or (iii) predicting the risk of developing, an inflammatory bowel disease in a patient. The invention also concerns the treatment of an inflammatory bowel disease. The invention further relates to the kits that are useful in the above methods for diagnosing/prognosing an inflammatory bowel disease, and in the treatment of an inflammatory bowel disease. In a particular embodiment, the inflammatory bowel disease is the Crohn's disease.
    Type: Application
    Filed: July 10, 2014
    Publication date: May 19, 2016
    Inventors: Stefan Catheline, Jean-Yves Chapelon, Remi Souchon, Pol Grasland-Mongrain, Cyril Lafon
  • Publication number: 20150141734
    Abstract: The method determines parameters to generate confocal ultrasound beams (B1,B2) inside a medium (4), and uses a device (1) comprising first and second ultrasound means (11,12) and first and second displacement members (13,14) for moving the ultrasound means (11,12). The parameters include signals s1,s2 to the ultrasound means (11,12), and the positions x1,x2 of the ultrasound means (11,12). The parameters are optimized for having a minimum amplitude a1,a2 of the signals s1,s2 and having an acoustic effect inside the medium (4).
    Type: Application
    Filed: March 8, 2013
    Publication date: May 21, 2015
    Inventors: Jean-Yves Chapelon, Cyril Lafon, Jean-Louis Mestas
  • Publication number: 20150112235
    Abstract: The object of the invention relates to an apparatus for the thermal treatment of biological tissues by means of the application of focused ultrasound waves, the apparatus including: a probe movement system (7) for ensuring: the moving of the focal zone (Z) along a first direction (X), from a distal point (D) of the treatment zone (T) to a proximal point (P) of the treatment zone, in order to create a sequence (S) of elementary treatment zones; the juxtaposition of sequences (S, S1, S2, S3, . . . ) of elementary treatment zones in order to completely cover the treatment zone (T); a control circuit (6) controlling the probe (2), in order to ensure that the ultrasonic power delivered to the focal zone decreases between the distal point (D) and the proximal point (P) of the treatment zone.
    Type: Application
    Filed: October 23, 2014
    Publication date: April 23, 2015
    Inventors: Lucie BRASSET, Jean-Yves CHAPELON, Nicolas GUILLEN, Francoise CHAVRIER, Emmanuel BLANC
  • Patent number: 8977361
    Abstract: The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator (4) made of non-ferromagnetic material comprising a casing (7), an ultrasound generating treating device (11) positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means (6) to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: March 10, 2015
    Assignees: Universite Pierre et Marie Curie (Paris 6), Assistance Publique—Hopitaux de Paris, Carthera
    Inventors: Alexandre Carpentier, Cyril Lafon, Jean-Yves Chapelon, Michael Sean Canney, Kévin Beccaria