Patents by Inventor Jean-Yves Le Brazidec

Jean-Yves Le Brazidec has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HSP90-inhibiting zearalanol compounds and methods of producing and using same
    Patent number: 7553979
    Abstract: Zearalanol compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various disorders. Methods of synthesis and use of such compounds are also described and claimed.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: June 30, 2009
    Assignee: Conforma Therapeutics Corporation
    Inventors: Srinivas R. Kasibhatla, Jean-Yves Le Brazidec, Sean Konrad McHugh, Marcus F. Boehm
  • Ansamycins having improved pharmacological and biological properties
    Patent number: 7465718
    Abstract: Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: December 16, 2008
    Assignee: Conforma Therapeutics Corporation
    Inventors: Lin Zhang, Jean-Yves Le Brazidec, Lawrence C. Fritz, Francis J. Burrows, Marcus F. Boehm, Junhua Fan, Sean Konrad McHugh
  • 7,9-Dihydro-Purin-8-One and Related Analogs as HSP90-Inhibitors
    Publication number: 20070253896
    Abstract: The invention relates in general to 7,9-dihydro-purin-8-one and related compounds that show broad utility, e.g., in inhibiting heat shock protein 90 (HSP90) to thereby treat or prevent HSP90-mediated diseases.
    Type: Application
    Filed: February 5, 2007
    Publication date: November 1, 2007
    Applicant: CONFORMA THERAPEUTICS CORPORATION
    Inventors: Jean-Yves Le Brazidec, Srinivas Kasibhatla, David Hurst, Marcus Boehm
  • Pyrrolopyrimidines and Related Analogs as HSP90-Inhibitors
    Publication number: 20070173483
    Abstract: Pyrrolopyrimidines and related analogs are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Methods of synthesis and use of such compounds are also described and claimed.
    Type: Application
    Filed: September 12, 2006
    Publication date: July 26, 2007
    Applicant: Conforma Therapeutics Corporation
    Inventors: Srinivas Kasibhatla, Jiandong Shi, Jean-Yves Le Brazidec, Marco Biamonte, Kevin Hong, Marcus Boehm
  • Pyrrolopyrimidines and related analogs as HSP90-inhibitors
    Patent number: 7138402
    Abstract: The present invention provides compounds represented by Formula I.
    Type: Grant
    Filed: September 20, 2004
    Date of Patent: November 21, 2006
    Assignee: Conforma Therapeutics Corporation
    Inventors: Srinivas R. Kasibhatla, Jiandong Shi, Jean-Yves Le Brazidec, Marco A. Biamonte, Kevin D. Hong, Marcus F. Boehm
  • Ansamycins having improved pharmacological and biological properties
    Publication number: 20050267122
    Abstract: Ansamycins and methods of preparing and using the same are described. At least some of these ansamycins exhibit one or more of improved aqueous formulation ability, chemical stability, and bioavailability. Some of the derivatives described are dimers. These and others described can include one or more solubilizing groups that have expected merit in rendering the overall compounds useful as drugs and prodrugs.
    Type: Application
    Filed: February 10, 2003
    Publication date: December 1, 2005
    Inventors: Lin Zhang, Jean-Yves Le Brazidec, Lawrence Fritz, Francis Burrows, Marcus Boehm, Junhua Fan, Sean McHugh
  • Hsp90-inhibiting zearalanol compounds and methods of producing and using same
    Publication number: 20050256183
    Abstract: Zearalanol compounds are described and demonstrated or predicted to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents in the treatment and prevention of various disorders. Methods of synthesis and use of such compounds are also described and claimed.
    Type: Application
    Filed: November 8, 2002
    Publication date: November 17, 2005
    Inventors: Srinivas Kasibhatla, Jean-Yves Le Brazidec, Sean McHugh, Marcus Boehm
  • Pyrrolopyrimidines and related analogs as HSP90-inhibitors
    Publication number: 20050107343
    Abstract: Pyrrolopyrimidines and related analogs are described and demonstrated to have utility as Heat Shock Protein 90 (HSP90) inhibiting agents used in the treatment and prevention of various HSP90 mediated disorders, e.g., proliferative disorders. Methods of synthesis and use of such compounds are also described and claimed.
    Type: Application
    Filed: September 20, 2004
    Publication date: May 19, 2005
    Inventors: Srinivas Kasibhatla, Jiandong Shi, Jean-Yves Le Brazidec, Marco Biamonte, Kevin Hong, Marcus Boehm