Abstract: Methods for selecting treatment paths are disclosed generally comprising the steps of: (a) discovering a set of treatment path clusters based on latent patterns in historical patient trace data, (b) building a set of binary classifiers based on historical patient trace data, historical patient data and target outcomes, and (c) given the treatment path clusters, actual patient data, and a selected target outcome, applying the binary classifiers to predict a treatment path for a new patient that optimizing the selected target outcome. Processor based systems to implement the methods are also disclosed.