Publication number: 20100292233
Abstract: The present invention relates to certain (1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl carboxylic acid derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the S1P1 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of S1P1 associated disorders, for example, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type I diabetes, sepsis, myocardial infarction, ischemic stroke, acne, microbial infections or diseases and viral infections or diseases.
Type:
Application
Filed:
January 22, 2009
Publication date:
November 18, 2010
Applicant:
ARENA PHARMACEUTICALS, INC.
Inventors:
Robert M. Jones, Daniel J. Buzard, Andrew M. Kawasaki, Luis A. Lopez, Jeanne V. Moody, Lars Thoresen, Brett Ullman