Patents by Inventor Jeanne Y. Wei

Jeanne Y. Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • p49/STRAP is a novel protein involved in gene regulation and cell proliferation
    Patent number: 8232098
    Abstract: The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: July 31, 2012
    Assignees: The Board of Trustees of the University of Arkansas, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Jeanne Y. Wei, Xiaomin Zhang
  • Method of screening for agents to treat heart failure
    Patent number: 8043801
    Abstract: The invention provides a method of identifying candidate agents to test for treating heart failure involving diastolic impairment, the method comprising: testing an agent to determine whether it (a) binds to serum response factor (SRF), (b) reduces SRF binding to a serum response element (SRE), or (c) reduces SRF protein levels in a cell; wherein if the agent does one or more of (a), (b), and (c), it is identified as a candidate agent.
    Type: Grant
    Filed: November 22, 2008
    Date of Patent: October 25, 2011
    Inventors: Jeanne Y. Wei, Gohar Azhar, Xiaomin Zhang
  • Method of screening for agents to treat heart failure
    Publication number: 20090187998
    Abstract: The invention provides a method of identifying candidate agents to test for treating heart failure involving diastolic impairment, the method comprising: testing an agent to determine whether it (a) binds to serum response factor (SRF), (b) reduces SRF binding to a serum response element (SRE), or (c) reduces SRF protein levels in a cell; wherein if the agent does one or more of (a), (b), and (c), it is identified as a candidate agent.
    Type: Application
    Filed: November 22, 2008
    Publication date: July 23, 2009
    Inventors: Jeanne Y. Wei, Gohar Azhar, Xiaomin Zhang
  • P49/STRAP is a novel protein involved in gene regulation and cell proliferation
    Patent number: 7498411
    Abstract: The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.
    Type: Grant
    Filed: March 22, 2007
    Date of Patent: March 3, 2009
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Jeanne Y. Wei, Xiaomin Zhang
  • P49/STRAP is a novel protein involved in gene regulation and cell proliferation
    Publication number: 20090035850
    Abstract: The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.
    Type: Application
    Filed: September 11, 2008
    Publication date: February 5, 2009
    Inventors: Jeanne Y. Wei, Xiaomin Zhang
  • p49/STRAP is a novel protein involved in gene regulation and cell proliferation
    Patent number: 7211427
    Abstract: The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.
    Type: Grant
    Filed: September 13, 2005
    Date of Patent: May 1, 2007
    Assignee: The Board of Trustees of the University of Arkansas
    Inventors: Jeanne Y. Wei, Xiaomin Zhang