Patents by Inventor Jeannie Zhang

Jeannie Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for synthesizing key intermediate of apixaban
    Patent number: 9656958
    Abstract: The invention relates to a method for synthesizing an intermediate of Apixaban comprising reacting a compound of formula I with 5-chloro-valeryl chloride in the presence of inorganic base in an inert solvent to obtain a compound of formula II, with the reaction formula of (A), wherein R is selected from nitro group and the group (B). The method is mild in reaction condition, simple in operation, easy in purification, inexpensive in production cost, environmental-friendly, and suitable for industrial production.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: May 23, 2017
    Assignees: Shanghai Syncores Technologies Inc. Ltd., Zhejiang Huahai Pharmaceutical Co., Ltd.
    Inventors: Boyu Wang, Jinfeng Yao, Luning Huang, Jeannie Zhang
  • NOVEL METHOD FOR SYNTHESIZING KEY INTERMEDIATE OF APIXABAN
    Publication number: 20160280646
    Abstract: The invention relates to a method for synthesizing an intermediate of Apixaban comprising reacting a compound of formula I with 5-chloro-valeryl chloride in the presence of inorganic base in an inert solvent to obtain a compound of formula II, with the reaction formula of (A), wherein R is selected from nitro group and the group (B). The method is mild in reaction condition, simple in operation, easy in purification, inexpensive in production cost, environmental-friendly, and suitable for industrial production.
    Type: Application
    Filed: July 29, 2014
    Publication date: September 29, 2016
    Inventors: Boyu Wang, Jinfeng Yao, Luning Huang, Jeannie Zhang
  • Method for synthesizing rivaroxaban intermediate, 4-(4-[(5S)-(aminomethyl)-2-oxo-1,3-oxazoligdin-3-YL]phenyl)morpholin-3-one
    Patent number: 9126990
    Abstract: The present invention discloses novel methods for synthesizing Rivaroxaban intermediate, i.e., 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one. The novel methods provided in the present invention involve mild reaction conditions, convenient operations, easy purification, and low production costs, and thus the process is environmental-friendly and suitable for industrial production.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: September 8, 2015
    Assignees: ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD, SHANGHAI SYNCORES TECHNOLOGIES, INC.
    Inventors: Chunpeng Zi, Luning Huang, Jeannie Zhang
  • NOVEL METHOD FOR SYNTHESIZING RIVAROXABAN INTERMEDIATE, 4-MORPHOLIN-3-ONE
    Publication number: 20140114066
    Abstract: The present invention discloses novel methods for synthesizing Rivaroxaban intermediate, i.e., 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3 -oxazolidin-3 -yl]phenyl}morpholin-3-one. The novel methods provided in the present invention involve mild reaction conditions, convenient operations, easy purification, and low production costs, and thus the process is environmental-friendly and suitable for industrial production.
    Type: Application
    Filed: January 18, 2012
    Publication date: April 24, 2014
    Applicants: SHANGHAI SYNCORES TECHNOLOGIES, INC., ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD
    Inventors: Chunpeng Zi, Luning Huang, Jeannie Zhang