Patent number: 9663545
Abstract: The invention relates to compounds characterized by a general formula (1), wherein X is a group described by a general formula —Kp—Fl—Kq—, wherein Fl is —C(?O)—, —C(?S)—, with l being 0 or 1, Kp is a Cp-alkyl with p being 0, 1, 2, 3 or 4, Kq is a Cq-alkyl with q being 0, 1, 2, 3 or 4, and wherein n of R1n is 0, 1, 2, 3, 4 or 5, and each R1 independently from any other R1 is —C(?O)OR2, —C(?O)NR22, —C(?O)SR2, —C(?S)OR2, —C(NH)NR22, CN4H2, —NR22, —C(?O)R2, —C(?S)R2, —OR2, —SR2, —CF3, —OCF3, —SCF3, —SOCF3, —SO2CF3, —CN, —NO2, —F, —Cl, —Br or —I, with each R2 independently from any other R2 being a hydrogen or C1-C4 alkyl, and wherein OM is an organometallic compound independently selected from the group of an unsubstituted or substituted metal sandwich compound, an unsubstituted or substituted half metal sandwich compound or a metal carbonyl compound and their use in a method for treatment of infections by helminths.
Type:
Grant
Filed:
July 1, 2014
Date of Patent:
May 30, 2017
Assignees:
UNIVERSITAT ZURICH, THE UNIVERSITY OF MELBOURNE
Inventors:
Jeannine Hess, Malay Patra, Gilles Gasser, Abdul Jabbar, Robin B. Gasser
Patent number: 9598451
Abstract: The invention comprises a compound characterized by a general formula (1), wherein X is a group described by a general formula —Kp—Fl—Kq—, wherein Fl is —C(?O)—, —C(?S)—, with l being 0 or 1, Kp is a Cp-alkyl with p being 0, 1, 2, 3 or 4, Kq is a Cq-alkyl with q being 0, 1, 2, 3 or 4, and wherein Z is a group described by a general formula —Kr—Fi—Kt—, wherein Fi —O—, —S—, —O—C(?O)—, —O—C(?S)—, —S—C(?O)— or —NH—(C?O)— with i being 0 or 1, Kr is a Cr-alkyl with r being 0, 1, 2, 3 or 4, Kt is a Ct-alkyl with t being 0, 1, 2, 3 or 4, wherein each OM is an organometallic compound independently selected from each other from the group of an unsubstituted or substituted metal sandwich compound, an unsubstituted or substituted half metal sandwich compound or a metal carbonyl compound and their use.
Type:
Grant
Filed:
September 26, 2014
Date of Patent:
March 21, 2017
Assignees:
UNIVERSITÄT ZÜRICH, THE UNIVERSITY OF MELBOURNE
Inventors:
Gilles Gasser, Robin B. Gasser, Jeannine Hess, Abdul Jabbar, Malay Patra
Publication number: 20160368939
Abstract: The invention relates to compounds characterized by a general formula (1), wherein X is a group described by a general formula —Kp—Fl—Kq—, wherein Fl is —C(?O)—, —C(?S)—, with l being 0 or 1, Kp is a Cp-alkyl with p being 0, 1, 2, 3 or 4, Kq is a Cq-alkyl with q being 0, 1, 2, 3 or 4, and wherein n of R1n is 0, 1, 2, 3, 4 or 5, and each R1 independently from any other R1 is —C(?O)OR2, —C(?O)NR22, —C(?O)SR2, —C(?S)OR2, —C(NH)NR22, CN4H2, —NR22, —C(?O)R2, —C(?S)R2, —OR2, —SR2, —CF3, —OCF3, —SCF3, —SOCF3, —SO2CF3, —CN, —NO2, —F, —Cl, —Br or —I, with each R2 independently from any other R2 being a hydrogen or C1-C4 alkyl, and wherein OM is an organometallic compound independently selected from the group of an unsubstituted or substituted metal sandwich compound, an unsubstituted or substituted half metal sandwich compound or a metal carbonyl compound and their use in a method for treatment of infections by helminths.
Type:
Application
Filed:
July 1, 2014
Publication date:
December 22, 2016
Inventors:
Jeannine HESS, Malay PATRA, Gilles GASSER, Abdul JABBAR, Robin B. GASSER