Abstract: Non-invasive electroencephalogram (EEG)-based methods for detecting a spreading depolarization secondary to a brain injury in a patient who exhibits high-amplitude delta activity in at least one channel of a scalp EEG of an injured brain hemisphere of the patient include (a) recording a baseline scalp EEG pattern in the patient at a channel exhibiting high amplitude delta activity; (b) recording a continuous scalp EEG pattern in the patient across a time frame at the at least one channel; and (c) detecting a spreading depolarization during the time frame by observing at least one feature indicative of a spreading depolarization in the continuous scalp EEG recording pattern relative to the baseline scalp EEG pattern at the at least one channel. Scalp EEG recordings are time-compressed prior to analysis. Methods of treating brain-injured patients and triaging brain-injured patients apply the non-invasive EEG methods.

Abstract: Computer-implemented methods and automated systems for real-time detection of spreading depolarizations in a brain injured patient, based an algorithm of (a) providing a reference data base of spreading depolarization waveform templates generated from EEG recordings of confirmed spreading depolarizations (SD) in a reference brain-injured patient cohort; (b) recording an EEG of the brain injured patient to generate recorded EEG waveforms; (c) detecting a slow potential change present in a recorded EEG waveform by applying a power spectral density estimate to the recorded waveform; (d) comparing a detected SPC to a reference database of SD waveform template to identify a candidate SD; and (e) rejecting a candidate SD as a false positive based on overall signal power and amplitude analysis and identifying a non-rejected candidate SD as a detected SD.

Abstract: Computer-implemented methods and automated systems for real-time detection of spreading depolarizations in a brain injured patient, based an algorithm of (a) providing a reference data base of spreading depolarization waveform templates generated from EEG recordings of confirmed spreading depolarizations (SD) in a reference brain-injured patient cohort; (b) recording an EEG of the brain injured patient to generate recorded EEG waveforms; (c) detecting a slow potential change present in a recorded EEG waveform by applying a power spectral density estimate to the recorded waveform; (d) comparing a detected SPC to a reference database of SD waveform template to identify a candidate SD; and (e) rejecting a candidate SD as a false positive based on overall signal power and amplitude analysis and identifying a non-rejected candidate SD as a detected SD.

Abstract: Non-invasive electroencephalogram (EEG)-based methods for detecting a spreading depolarization secondary to a brain injury in a patient who exhibits high-amplitude delta activity in at least one channel of a scalp EEG of an injured brain hemisphere of the patient include (a) recording a baseline scalp EEG pattern in the patient at a channel exhibiting high amplitude delta activity; (b) recording a continuous scalp EEG pattern in the patient across a time frame at the at least one channel; and (c) detecting a spreading depolarization during the time frame by observing at least one feature indicative of a spreading depolarization in the continuous scalp EEG recording pattern relative to the baseline scalp EEG pattern at the at least one channel. Scalp EEG recordings are time-compressed prior to analysis. Methods of treating brain-injured patients and triaging brain-injured patients apply the non-invasive EEG methods.

Abstract: Aspects of this invention include the use of G-2MePE to treat patients with brain injury characterized by non-convulsive seizures. G-2MePE is useful in treating brain injuries caused by traumatic brain injury, stroke, hypoxia/ischemia and toxic injury.

Abstract: Aspects of this invention include the use of G-2MePE to treat patients with brain injury characterized by non-convulsive seizures. G-2MePE is useful in treating brain injuries caused by traumatic brain injury, stroke, hypoxia/ischemia and toxic injury.