Patents by Inventor Jed F. Fisher
Jed F. Fisher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7244755Abstract: Disclosed are compounds of formula I: and the pharmaceutically acceptable salts thereof wherein the variables RN, R1, R2, R3, RP and RC are defined herein. These compounds are useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.Type: GrantFiled: October 4, 2002Date of Patent: July 17, 2007Assignee: Pharmacia & Upjohn CompanyInventors: Jed F. Fisher, Jon S. Jacobs, Brian Sherer
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Patent number: 6903090Abstract: Disclosed are compounds of Formula (I): wherein R1-R4, p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions containing such compounds or salts. The compounds and salts are 5-HT ligands and are useful for treating diseases, disorders, and/or conditions in a mammal wherein activity of a 5-HT receptor is implicated. The compounds and salts are particularly useful for treating diseases of the central nervous system.Type: GrantFiled: March 20, 2003Date of Patent: June 7, 2005Assignee: PfizerInventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, William W. McWhorter, Jr., Jeanette K. Morris, Donald Joseph Rogier, Eric Jon Jacobsen
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Patent number: 6828314Abstract: The invention provides compounds of Formula (I): wherein R1-R4, p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions containing such compounds or salts. The compounds and salts are 5-HT ligands and are useful for treating diseases, disorders, and/or conditions in a mammal wherein activity of a 5-HT receptor is implicated. The compounds and salts are particularly useful for treating diseases of the central nervous system.Type: GrantFiled: March 20, 2003Date of Patent: December 7, 2004Assignee: PfizerInventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, Eric Jon Jacobsen, William W. McWhorter, Jr., Jeanette K. Morris, Donald Joseph Rogier
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Publication number: 20040110802Abstract: The invention provides antimicrobial agents and methods of using the agents for sterilization, sanitation, antisepsis, disinfection, and treatment of infections in mammals.Type: ApplicationFiled: August 20, 2003Publication date: June 10, 2004Inventors: Atli Thorarensen, J. Craig Ruble, Jed F. Fisher, Donna Lee Romero, Thomas J. Beauchamp, Jill M. Northuis
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Publication number: 20030225058Abstract: The invention provides compounds of Formula (I): 1Type: ApplicationFiled: March 20, 2003Publication date: December 4, 2003Applicant: Pharmacia & UpJohn CompanyInventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-Min Fu, Eric Jon Jacobsen, William W. McWhorter, Jeanette K. Morris, Donald Joseph Rogier
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Publication number: 20030220321Abstract: Disclosed are compounds of Formula (I): 1Type: ApplicationFiled: March 20, 2003Publication date: November 27, 2003Applicant: Pharmacia & UpJohn CompanyInventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-Min Fu, William W. McWhorter, Jeanette K. Morris, Donald Joseph Rogier, Eric Jon Jacobsen
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Patent number: 6596752Abstract: The present invention relates to small molecules according to the formula [I]: which are potent inhibitors of &agr;4&bgr;1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing &agr;4&bgr;1 adhesion mediated conditions in a mammal such as a human.Type: GrantFiled: July 12, 2002Date of Patent: July 22, 2003Assignees: Tanabe Seiyaku Co., Ltd., Pharmacia & Upjohn CompanyInventors: Thomas J. Lobl, Bradley R. Teegarden, Alexander Polinsky, Gilbert M. Rishton, Masafumi Yamagishi, Steven Tanis, Jed F. Fisher, Edward W. Thomas, Robert A. Chrusciel
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Publication number: 20030130349Abstract: The present invention relates to small molecules according to the formula [I]: 1Type: ApplicationFiled: July 12, 2002Publication date: July 10, 2003Applicant: Tanabe Seiyaku Co., Ltd.Inventors: Thomas J. Lobl, Bradley R. Teegarden, Alexander Polinsky, Gilbert M. Rishton, Masafumi Yamagishi, Steven Tanis, Jed F. Fisher, Edward W. Thomas, Robert A. Chrusciel
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Publication number: 20030125365Abstract: Disclosed are compounds of formula I: 1Type: ApplicationFiled: October 4, 2002Publication date: July 3, 2003Inventors: Jed F. Fisher, Jon S. Jacobs, Brian Sherer
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Patent number: 6586421Abstract: The invention provides compounds of Formula (I): wherein R1-R4, p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions containing such compounds or salts. The compounds and salts are 5-HT ligands and are useful for treating diseases, disorders, and/or conditions in a mammal wherein activity of a 5-HT receptor is implicated. The compounds and salts are particularly useful for treating diseases of the central nervous system.Type: GrantFiled: September 20, 2001Date of Patent: July 1, 2003Assignee: Pharmacia & Upjohn CompanyInventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, Eric Jon Jacobsen, William W. McWhorter, Jr., Jeanette K. Morris, Donald Joseph Rogier
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Patent number: 6583135Abstract: Disclosed are compounds of Formula (I): wherein R1-R4, p and q have any of the values described in the specification, as well as pharmaceutical salts thereof, and pharmaceutical compositions containing such compounds or salts. The compounds and salts are 5-HT ligands and are useful for treating diseases, disorders, and/or conditions in a mammal wherein activity of a 5-HT receptor is implicated. The compounds and salts are particularly useful for treating diseases of the central nervous system.Type: GrantFiled: September 20, 2001Date of Patent: June 24, 2003Assignee: Pharmacia & Upjohn CompanyInventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, William W. McWhorter, Jr., Jeanette K. Morris, Donald Joseph Rogier, Eric Jon Jacobsen
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Patent number: 6482849Abstract: The present invention relates to small molecules according to the formula [I]: which are potent inhibitors of &agr;4&bgr;1 mediated adhesion to either VCAM or CS-1 and which can be used for treating or preventing &agr;4&bgr;1 adhesion mediated conditions in a mammal such as a human.Type: GrantFiled: June 23, 1998Date of Patent: November 19, 2002Assignees: Tanabe Seiyaku Co., Ltd., Pharmacia & Upjohn CompanyInventors: Thomas J. Lobl, Bradley R. Teegarden, Alexander Polinsky, Gilbert M. Rishton, Masafumi Yamagishi, Steven Tanis, Jed F. Fisher, Edward W. Thomas, Robert A. Chrusciel
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Publication number: 20020107278Abstract: Disclosed are compounds of Formula (I): 1Type: ApplicationFiled: September 20, 2001Publication date: August 8, 2002Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, William W. McWhorter, Jeanette K. Morris, Donald Joseph Rogier, Eric Jon Jacobsen
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Publication number: 20020077318Abstract: The invention provides compounds of Formula (I): 1Type: ApplicationFiled: September 20, 2001Publication date: June 20, 2002Inventors: Kristine E. Frank, Brad A. Acker, Michael D. Ennis, Jed F. Fisher, Jian-min Fu, Eric Jon Jacobsen, William W. McWhorter, Jeanette K. Morris, Donald Joseph Rogier
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Patent number: 5844091Abstract: Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine cell hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.Type: GrantFiled: June 25, 1993Date of Patent: December 1, 1998Assignee: University of Maryland, BaltimoreInventors: Mordecai P. Blaustein, John M. Hamlyn, Douglas W. Harris, James H. Ludens, William Rodney Mathews, Jed F. Fisher, Frederic Mandel, Donald W. DuCharme
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Patent number: 5695756Abstract: Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine cell hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.Type: GrantFiled: June 6, 1995Date of Patent: December 9, 1997Assignee: University of Maryland at BaltimoreInventors: Mordecai P. Blaustein, John M. Hamlyn, Douglas W. Harris, James H. Ludens, William Rodney Mathews, Jed F. Fisher, Frederic Mandel, Donald W. DuCharme
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Patent number: 5429928Abstract: Methods using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject are disclosed.Type: GrantFiled: July 28, 1992Date of Patent: July 4, 1995Assignee: University of Maryland at BaltimoreInventors: Mordecai P. Blaustein, John M. Hamlyn, Douglas W. Harris, James H. Ludens, William R. Mathews, Jed F. Fisher, Frederic Mandel, Donald W. DuCharme
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Patent number: 5164296Abstract: Methods for diagnosing pre-hypertension, hypertension, congestive cardiomyopathy, renal failure, salt-sensitivity and adenomas and endocrine cell hyperplasias are disclosed. Also disclosed are methods for monitoring hypertension therapy, congestive cardiomyopathy therapy, renal failure therapy and adenoma and endocrine call hyperplasia therapy. These methods involve using an antibody having binding specificity to ouabain to immunologically measure the level of human ouabain in body fluid or tissue of a subject. Additionally, methods for treating a hypertensive subject by inducing passive or active immunity to human ouabain in the subject are disclosed, along with an antibody having binding specificity for ouabain.Type: GrantFiled: August 31, 1990Date of Patent: November 17, 1992Assignee: University of Maryland at BaltimoreInventors: Mordecai P. Blaustein, John M. Hamlyn, Douglas W. Harris, James H. Ludens, William R. Mathews, Jed F. Fisher, Frederic Mandel, Donald W. DuCharme
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Patent number: 4534971Abstract: A method for the preparation of light-stable water-soluble complexes of antitumor antibiotics and binding protein and the resulting products. The antibiotics are of the anthracycline and anthraquinone classes, as defined. The binding protein is purified apo riboflavin binding protein from eggs. The complexes are prepared by admixing solutions of the antibiotic and protein in substantially equimolar proportions. The complexes are useful for preparing stable aqueous solutions of the antibiotics for oral delivery and for redox titrations of anthracyclines.Type: GrantFiled: October 20, 1982Date of Patent: August 13, 1985Assignee: Regents of the University of MinnesotaInventor: Jed F. Fisher
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Patent number: 4341766Abstract: Method and compositions for deactivating bacterial hydrolytic enzymes which attack .beta.-lactam antibiotics.Type: GrantFiled: June 27, 1980Date of Patent: July 27, 1982Assignee: Harvard CollegeInventors: Jed F. Fisher, Jeremy R. Knowles