Patents by Inventor Jed K. Johnson
Jed K. Johnson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240131218Abstract: A composition comprising a plurality of electrospun fiber fragments comprising at least one polymer, a plurality of electrospun fiber fragment clusters comprising at least one polymer, and, optionally, a carrier medium, is disclosed. Also disclosed is a kit comprising a first component of a plurality of electrospun fiber fragments, and a second component of a carrier medium. Also disclosed is a composition comprising a plurality of micronized electrospun fiber fragments, a carrier medium, and, optionally, a plurality of cells. Also disclosed is a biocompatible textile comprising a plurality of micronized electrospun fiber fragments. Also disclosed is a biocompatible suture comprising at least one electrospun fiber.Type: ApplicationFiled: January 2, 2024Publication date: April 25, 2024Applicant: NFS IP Holdings, LLCInventors: Jed K. JOHNSON, Ross KAYUHA
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Patent number: 11806440Abstract: The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.Type: GrantFiled: December 22, 2020Date of Patent: November 7, 2023Assignee: NFS IP Holdings, LLCInventors: Jed K. Johnson, Devan Ohst, Jason Chakroff, Brian Cohen, Anthony Romeo
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Patent number: 11737990Abstract: A system for manufacturing an artificial construct suitable for transplantation into a biological organism that includes a two or three three-dimensional preform that is based on the actual two or three-dimensional structure of a native mammalian tissue; and an electrospinning apparatus, wherein the electrospinning apparatus is operative to deposit at least one layer of polymer fibers on the preform to form a polymer scaffold, and wherein the orientation of the fibers in the scaffold relative to one another is substantially parallel.Type: GrantFiled: April 10, 2020Date of Patent: August 29, 2023Assignee: NFS IP Holdings, LLCInventor: Jed K. Johnson
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Publication number: 20230061170Abstract: A synthetic construct suitable for implantation into a biological organism that includes at least one polymer scaffold; wherein the at least one polymer scaffold includes at least one layer of polymer fibers that have been deposited by electrospinning; wherein the orientation of the fibers in the at least one polymer scaffold relative to one another is generally parallel, random, or both; and wherein the at least one polymer scaffold has been adapted to function as at least one of a substantially two-dimensional implantable structure and a substantially three-dimensional implantable tubular structure.Type: ApplicationFiled: April 12, 2022Publication date: March 2, 2023Applicant: NFS IP Holdings, LLCInventors: Jed K. Johnson, Ross Kayuha
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Publication number: 20220395609Abstract: Disclosed herein are methods of controlling a composition of M1/M2 macrophages in a wound of a subject. The method can include applying an electrospun structure to the wound, wherein the electrospun structure comprises a polymer, wherein the polymer comprises an alpha-hydroxy acid, and keeping the electrospun structure on the wound for a time period. The presence of the electrospun structure on the wound causes an increase in presence of M2 macrophages relative to M1 macrophages, which can, in turn, promote healing of the wound.Type: ApplicationFiled: June 15, 2022Publication date: December 15, 2022Applicant: Nanofiber Solutions, LLCInventors: Jed K. Johnson, Ronald Lloyd Bracken
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Publication number: 20220133950Abstract: A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.Type: ApplicationFiled: January 14, 2022Publication date: May 5, 2022Applicant: Nanofiber Solutions, LLCInventor: Jed K. Johnson
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Publication number: 20220133946Abstract: A composition comprising a plurality of electrospun fiber fragments comprising at least one polymer, a plurality of electrospun fiber fragment clusters comprising at least one polymer, and, optionally, a carrier medium, is disclosed. Also disclosed is a kit comprising a first component of a plurality of electrospun fiber fragments, and a second component of a carrier medium. Also disclosed is a composition comprising a plurality of micronized electrospun fiber fragments, a carrier medium, and, optionally, a plurality of cells. Also disclosed is a biocompatible textile comprising a plurality of micronized electrospun fiber fragments. Also disclosed is a biocompatible suture comprising at least one electrospun fiber.Type: ApplicationFiled: January 13, 2022Publication date: May 5, 2022Applicant: Nanofiber Solutions, LLCInventors: Jed K. Johnson, Ross Kayuha
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Publication number: 20220111578Abstract: Systems and methods of fabricating corrugated electrospun fiber assemblies are disclosed herein. The method can include placing an electrospun fiber scaffold on a corrugation rod, wherein the corrugation rod comprises a helical structure; applying a monofilament fiber about the electrospun fiber scaffold and the corrugation rod from a dispenser as the dispenser is translated longitudinally and the corrugation rod is rotated such that the monofilament fiber is wrapped about the electrospun fiber scaffold at a defined threads per inch (TPI) to form a wrapped electrospun fiber assembly; and longitudinally compressing the corrugated electrospun fiber assembly until it has been compressed from a first length to a second length to form the corrugated electrospun fiber assembly. The corrugated electrospun fiber assemblies can be kink-resistant as compared to conventional electrospun fiber scaffolds. The corrugated electrospun fiber assemblies can be used in, for example, biological applications within a subject.Type: ApplicationFiled: October 13, 2021Publication date: April 14, 2022Applicant: Nanofiber Solutions, LLCInventors: Jed K. Johnson, Kevin Nelson, Tyler Groehl
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Patent number: 11246959Abstract: A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.Type: GrantFiled: June 17, 2020Date of Patent: February 15, 2022Assignee: NANOFIBER SOLUTIONS, LLCInventor: Jed K. Johnson
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Publication number: 20210259988Abstract: Systems and methods of forming electrospun structures including pharmaceuticals are disclosed. An electrospun structure can include one or more polymers electrospun from a polymer solution comprising a pharmaceutical such that the pharmaceutical is dispersed throughout the one or more electrospun polymers. The pharmaceutical can include a cannabinoid, a phytocannabinoid, a terpene produced by a Cannabis plant, or a combination thereof. The one or more electrospun polymer are configured to degrade over a predetermined time period to deliver the pharmaceutical over the predetermined time period.Type: ApplicationFiled: February 22, 2021Publication date: August 26, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Katie KAFFENBARGER, Devan OHST, Ross KAYUHA
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Publication number: 20210138108Abstract: A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.Type: ApplicationFiled: June 17, 2020Publication date: May 13, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventor: Jed K. JOHNSON
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Publication number: 20210138104Abstract: A composition comprising a plurality of electrospun fiber fragments comprising at least one polymer, a plurality of electrospun fiber fragment clusters comprising at least one polymer, and, optionally, a carrier medium, is disclosed. Also disclosed is a kit comprising a first component of a plurality of electrospun fiber fragments, and a second component of a carrier medium. Also disclosed is a composition comprising a plurality of micronized electrospun fiber fragments, a carrier medium, and, optionally, a plurality of cells. Also disclosed is a biocompatible textile comprising a plurality of micronized electrospun fiber fragments. Also disclosed is a biocompatible suture comprising at least one electrospun fiber.Type: ApplicationFiled: January 15, 2021Publication date: May 13, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Ross KAYUHA
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Publication number: 20210106720Abstract: The instant disclosure is directed to methods of improving bone-soft tissue healing using biocompatible electrospun polymer fibers. In one embodiment, a method may include locating a portion of a subject's bone, affixing a tendon or ligament to the bone using a hardware fixture, and placing a patch comprising at least one electrospun polymer fiber in physical communication with both the bone and the tendon or ligament. In some embodiments, the bone may be a humerus, and the tendon or ligament may be a supraspinatus tendon. In certain embodiments, the patch may comprise substantially parallel electrospun polymer fibers, and may be placed such that the fibers are also substantially parallel with the long axis of the tendon or ligament.Type: ApplicationFiled: December 22, 2020Publication date: April 15, 2021Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Devan OHST, Jason CHAKROFF, Brian COHEN, Anthony ROMEO
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Publication number: 20200245658Abstract: A cultured meat product may comprise a scaffold comprising an electro spun polymer fiber, and a population of cells. The cultured meat product may have a thickness from about 100 ?m to about 500 mm. A method of producing such a cultured meat product may comprise preparing the scaffold, placing the scaffold into a bioreactor, adding the population of cells to the bioreactor, culturing the population of cells in the bioreactor containing the scaffold for a period of time, thereby forming the cultured meat product, and removing the cultured meat product from the bioreactor. The cultured meat product may be configured to mimic the taste, texture, size, shape, and/or topography of a traditional slaughtered meat.Type: ApplicationFiled: February 3, 2020Publication date: August 6, 2020Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Devan OHST
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Publication number: 20200237680Abstract: A system for manufacturing an artificial construct suitable for transplantation into a biological organism that includes a two or three three-dimensional preform that is based on the actual two or three-dimensional structure of a native mammalian tissue; and an electrospinning apparatus, wherein the electrospinning apparatus is operative to deposit at least one layer of polymer fibers on the preform to form a polymer scaffold, and wherein the orientation of the fibers in the scaffold relative to one another is substantially parallel.Type: ApplicationFiled: April 10, 2020Publication date: July 30, 2020Applicant: NANOFIBER SOLUTIONS, LLCInventor: Jed K. JOHNSON
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Patent number: 10653635Abstract: A system for manufacturing an artificial construct suitable for transplantation into a biological organism that includes a two or three three-dimensional preform that is based on the actual two or three-dimensional structure of a native mammalian tissue; and an electrospinning apparatus, wherein the electrospinning apparatus is operative to deposit at least one layer of polymer fibers on the preform to form a polymer scaffold, and wherein the orientation of the fibers in the scaffold relative to one another is substantially parallel.Type: GrantFiled: December 29, 2017Date of Patent: May 19, 2020Assignee: NANOFIBER SOLUTIONS, LLCInventor: Jed K. Johnson
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Patent number: 10562225Abstract: A system for manufacturing a synthetic organ suitable for transplantation into a biological organism is provided. This synthetic organ includes a three-dimensional polymer scaffold, wherein the shape and dimensions of the polymer scaffold are based on a native organ, wherein the polymer scaffold further includes at least one layer of polymer fibers that have been deposited by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both; and wherein the polymer scaffold has been preseeded with at least one type of biological cell prior to implantation into a biological organism, and wherein the at least one type of biological cell is operative to facilitate integration of the polymer scaffold into the organism so that the polymer scaffold may function in a manner significantly similar to or the same as the native organ.Type: GrantFiled: December 15, 2014Date of Patent: February 18, 2020Assignee: NANOFIBER SOLUTIONS, LLCInventor: Jed K. Johnson
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Publication number: 20190271098Abstract: The instant disclosure is directed to flexible electrospun fiber rods and methods of manufacturing such rods. A scaffold may comprise a flexible rod having a spiral cross-section, the flexible rod comprising electrospun polymer fibers. The electrospun polymer fibers may be substantially aligned or randomly oriented with respect to one another. The flexible rod may further comprise substantially uniformly distributed pores. The flexible rod may have a length and a diameter of a native mammalian tendon or ligament. A method of manufacturing such a scaffold may comprise forming a layer of polymer fibers on a mandrel by electrospinning, rolling the layer from a first end of the mandrel to a second end of the mandrel to form a toroid at the second end of the mandrel, and cutting the toroid off the mandrel to form a flexible rod having a spiral cross-section.Type: ApplicationFiled: March 4, 2019Publication date: September 5, 2019Applicant: NANOFIBER SOLUTIONS, LLCInventors: Jed K. JOHNSON, Devan Ohst, Michael Helterbran
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Patent number: 10294449Abstract: A substrate for culturing cells that includes at least one fiber scaffold adapted to be contained within a disposable or non-disposable bioreactor, wherein the fiber scaffold further includes polymer fibers that have been created by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both.Type: GrantFiled: August 20, 2013Date of Patent: May 21, 2019Assignee: NANOFIBER SOLUTIONS, LLCInventor: Jed K. Johnson
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Patent number: 10239262Abstract: A synthetic organ suitable for transplantation into a biological organism is provided. This synthetic organ includes a three-dimensional polymer scaffold, wherein the shape and dimensions of the polymer scaffold are based on a native organ, wherein the polymer scaffold further includes at least one layer of polymer fibers that have been deposited by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both; and wherein the polymer scaffold has been preseeded with at least one type of biological cell prior to implantation into a biological organism, and wherein the at least one type of biological cell is operative to facilitate integration of the polymer scaffold into the organism so that the polymer scaffold may function in a manner significantly similar to or the same as the native organ.Type: GrantFiled: November 15, 2012Date of Patent: March 26, 2019Assignee: NANOFIBER SOLUTIONS, LLCInventor: Jed K. Johnson