Patents by Inventor Jee Hee Suh

Jee Hee Suh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10485786
    Abstract: The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: November 26, 2019
    Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Kyu-Yang Yi, Sung-Eun Yoo, Nack-Jeong Kim, Jee-Hee Suh, Choun-Ki Joo, Jun-Sub Choi, Jae-Sik Yang, Geun-Hyeog Lee, Yun-Seok Cho, Jin-Ha Park, Hye-Sung Lee
  • Publication number: 20180221343
    Abstract: The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.
    Type: Application
    Filed: March 30, 2018
    Publication date: August 9, 2018
    Applicants: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION
    Inventors: Kyu-Yang YI, Sung-Eun YOO, Nack-Jeong KIM, Jee-Hee SUH, Choun-Ki JOO, Jun-Sub CHOI, Jae-Sik YANG, Geun-Hyeog LEE, Yun-Seok CHO, Jin-Ha PARK, Hye-Sung LEE
  • Patent number: 9364468
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis, comprising: (a) a pharmaceutically effective amount of a compound represented by the following chemical formula 1; and (b) a pharmaceutically acceptable carrier. Chemical formula 1 The compound contained as an active ingredient of the present invention inhibits the expression and activity of CO-DH in tubercle bacillus so as to effectively block the detoxification of carbon monoxide, which is an important survival factor of tubercle bacillus, and is safe for the human body since the compound targets CO-DH which does not exist in the human body. In addition, the compound creates a synergistic effect when combined with a conventional tuberculostatic drug, and thus can be more effective for treating tuberculosis.
    Type: Grant
    Filed: February 13, 2013
    Date of Patent: June 14, 2016
    Assignee: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
    Inventors: Young Min Kim, Seung Jung Han, Tae Gwon Oh, Sae Woong Park, Sang Nae Cho, Mi Young Hahn, Jee Hee Suh, Kyu Yang Yi
  • Patent number: 9090608
    Abstract: A pharmaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(?O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: July 28, 2015
    Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Nak Jeong Kim, Myung-Ae Bae, Sung-Eun Yoo, Namsook Kang, Jung Nyoung Heo, Kyu Yang Yi, Jee Hee Suh, Sung Youn Chang, Eun Sook Hwang, Jeong-Ho Hong
  • Publication number: 20150133503
    Abstract: The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis, comprising: (a) a pharmaceutically effective amount of a compound represented by the following chemical formula 1; and (b) a pharmaceutically acceptable carrier. Chemical formula 1 The compound contained as an active ingredient of the present invention inhibits the expression and activity of CO-DH in tubercle bacillus so as to effectively block the detoxification of carbon monoxide, which is an important survival factor of tubercle bacillus, and is safe for the human body since the compound targets CO-DH which does not exist in the human body. In addition, the compound creates a synergistic effect when combined with a conventional tuberculostatic drug, and thus can be more effective for treating tuberculosis.
    Type: Application
    Filed: February 13, 2013
    Publication date: May 14, 2015
    Inventors: Young Min Kim, Seung Jung Han, Tae Gwon Oh, Sae Woong Park, Sang Nae Cho, Mi Young Hahn, Jee Hee Suh, Kyu Yang Yi
  • Publication number: 20140018402
    Abstract: The present invention provides a pharmaceutical composition for preventing or treating macular degeneration, which comprises benzopyran derivatives substituted with secondary amines including imidazole or pharmaceutically acceptable salts thereof as an active ingredient. The pharmaceutical composition of the present invention may be used in the form of eye drops.
    Type: Application
    Filed: March 29, 2011
    Publication date: January 16, 2014
    Applicants: CATHOLIC UNIVERSITY INDUSTRY ACADEMIC COOPERATION FOUNDATION, KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Kyu-Yang Yi, Sung-Eun Yoo, Nack-Jeong Kim, Jee-Hee Suh, Choun-Ki Joo, Jun-Sub Choi, Jae-Sik Yang, Geun-Hyeog Lee, Yun-Seok Cho, Jin-Ha Park, Hye-Sung Lee
  • Patent number: 8372862
    Abstract: A phamaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(?O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, ?or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.
    Type: Grant
    Filed: April 22, 2010
    Date of Patent: February 12, 2013
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Nak Jeong Kim, Myung-Ae Bae, Sung-Eun Yoo, Namsook Kang, Jung Nyoung Heo, Kyu Yang Yi, Jee Hee Suh, Sung Youn Chang, Eun Sook Hwang, Jeong-Ho Hong
  • Patent number: 8198307
    Abstract: The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.
    Type: Grant
    Filed: May 13, 2008
    Date of Patent: June 12, 2012
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Jee Hee Suh, Kyu Yang Yi, Nack Jeong Kim, Sung Eun Yoo, Kwang-Seok Oh, Hyae Gyeong Cheon, Mija Ahn, Byung Ho Lee, Won Hoon Jung, Sang Dal Rhee
  • Patent number: 8143307
    Abstract: The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models.
    Type: Grant
    Filed: December 27, 2005
    Date of Patent: March 27, 2012
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Kyu Yang Yi, SunKyung Lee, Jee Hee Suh, Nak Jeong Kim, Hyunsuk Lee, Byung-Ho Lee, Sung-eun Yoo, Kyung-Hee Lee, Yong Oh Lee
  • Publication number: 20100305324
    Abstract: A phamaceutical composition comprising a phenyltetrazole derivative of formula (I) or a pharmaceutical acceptable salt thereof is effective in preventing or treating osteoporosis, obesity, diabetes, or hyperlipidemia, by regulating protein TAZ. wherein, A is ethyl or n-butyl; R1 is methyl, —CH2OH, —CO2CH3, —CH2F, —CH(OCH3)2, —CH2OC(?O)CH3, styryl or —CH2OCH2SCH3; R2 is H, Br, —CO2CH3, phenyl, pyridin-2-yl, pyridin-3-yl, ?or styryl; R3 is H or methyl; X is CH or N; and P is H or —CH(CH3)OCH2CH3.
    Type: Application
    Filed: April 22, 2010
    Publication date: December 2, 2010
    Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Nak Jeong KIM, Myung-Ae Bae, Sung-Eun Yoo, Namsook Kang, Jung Nyoung Heo, Kyu Yang Yi, Jee Hee Suh, Sung Youn Chang, Eun Sook Hwang, Jeong-Ho Hong
  • Publication number: 20100145054
    Abstract: The present invention is directed to a novel imidazole derivative having an aryl piperidine substituent of formula (I) and a method for preparation thereof, and a pharmaceutical composition containing said imidazole derivative as an active ingredient for preventing or treating a MCH (melanine-concentrating hormone)-related disease.
    Type: Application
    Filed: May 13, 2008
    Publication date: June 10, 2010
    Applicant: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: Jee Hee Suh, Kyu Yang YI, Nack Jeong KIM, Sung Eun Yoo, Kwang-Seok Oh, Hyae Gyeong Cheon, Mija Ahn, Byung Ho Lee, Won Hoon Jung, Sang Dal Rhee
  • Publication number: 20100004466
    Abstract: The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models.
    Type: Application
    Filed: December 27, 2005
    Publication date: January 7, 2010
    Inventors: Kyu Yang Yi, SunKyung Lee, Jee Hee Suh, Nak Jeong Kim, Hyunsuk Lee, Byung-Ho Lee, Sung-eun Yoo, Kyung-Hee Lee, Yong Oh Lee
  • Patent number: 7420060
    Abstract: The present invention relates to benzopyran derivatives substituted with a thioxobenzoxazole derivative, or pharmaceutically acceptable salts thereof, processes for preparing the same and a pharmaceutical composition containing the above as an effective ingredient Benzopyran derivatives substituted with thioxobenzoxazole derivatives, represented in <Formula 1>, have the function of protecting heart from ischemia-reperfusion both in vivo and in vitro, so that a pharmaceutical composition containing benzopyran derivatives substituted with thioxobenzoxoazole derivatives or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc, and for the treatment of diseases caused by ischemia-reperfusion.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: September 2, 2008
    Assignee: Schaeffler KG
    Inventors: Hong Lim, Dong Ha Lee, Sun Ok Kim, Sung-Eun Yoo, Kyu Yang Yi, Sun Kyung Lee, Jee Hee Suh, Nak Jeong Kim, Sun Kyung Hwang, Tae Mi Kim, Byung Ho Lee, Ho-Won Seo
  • Patent number: 7414068
    Abstract: The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: August 19, 2008
    Assignee: Dongbu Hannong Chemical Co., Ltd.
    Inventors: Hong Lim, Dong-Ha Lee, Sun-Ok Kim, In-Young Choi, Sung-Eun Yoo, Kyu-Yang Yi, Sun-Kyung Lee, Jee-Hee Suh, Nak-Jeong Kim, Byung-Ho Lee, Ho-Won Seo, Hwa-Sup Shin
  • Patent number: 7351843
    Abstract: The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same. Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be effectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.
    Type: Grant
    Filed: December 24, 2004
    Date of Patent: April 1, 2008
    Assignees: Korea Research Institute of Chemical Technology, Yuyu, Inc.
    Inventors: Kyu Yang Yi, Sun Kyung Lee, Nak Jeong Kim, Jee Hee Suh, Soon Hee Hwang, Byung Ho Lee, Ho Won Seo, Sun Kyung Hwang, Sung Eun Yoo, Kyung Hee Lee
  • Patent number: 7309793
    Abstract: The present invention relates to benzopyran derivatives substituted with a benzimidazole derivative, or pharmaceutically acceptable salts thereof, a preparation method of the same and pharmarceutical compositions containing them. Benzopyran derivatives substituted with a benzimidazole derivative, represented in Formula (1), have the function of protecting heart from ischemia-reperfusion without side effect like vasodilation, so that a pharmaceutical composition containing benzopyran derivatives substituted with a benzimidazole derivative or pharmaceutically acceptable salts thereof of the present invention as an effective ingredient can be effectively used for the protection of tissues influenced by ischemia-reperfusion, for example, for the protection of heart, nervous cells, brain, retinal cells, storage organs, etc. and for the treatment of diseases caused by ischemia-reperfusion.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: December 18, 2007
    Assignee: Dongbu Hannong Chemical Co., Ltd.
    Inventors: Hong Lim, Dong Ha Lee, Sun Ok Kim, Sung-Eun Yoo, Kyu Yang Yi, Sun Kyung Lee, Jee Hee Suh, Nak Jeong Kim, Sun Kyung Hwang, Tae Mi Kim, Byung Ho Lee, Ho-Won Seo
  • Patent number: 7279497
    Abstract: The present invention relates to benzopyran derivatives substituted with secondary amines including imidazole, their preparation, and pharmaceutical compositions containing them. The present invention is pharmacologically useful for the treatment of cancer, rheumatoid arthritis, and diabetic retinopathies through anti-angiogenic properties, and also pharmacologically useful in the protection of heart and neuronal cells against ischemia-reperfusion injury or preserving organs.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: October 9, 2007
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Kyu Yang Yi, Sun Kyung Lee, Sung-Eun Yoo, Jee Hee Suh, Nak Jeong Kim, Sun Kyung Hwang, Byung-Ho Lee, Ho Won Seo, Chong Ock Lee, Sang-Un Choi
  • Publication number: 20060035948
    Abstract: The present invention relates to benzopyran derivatives substituted with secondary amines including tetrazole, method for preparing thereof and pharmaceutical compositions containing them. The compounds of the present invention can be used for protecting neuronal cells and brain damage; antioxidation; inhibiting NO generation; protecting heart; suppressing angiogenesis; protecting preserving organs such as kidney, heart and tissue, and protecting organs in major cardiovascular surgery.
    Type: Application
    Filed: April 10, 2003
    Publication date: February 16, 2006
    Inventors: Hong Lim, Dong-Ha Lee, Sun-Ok Kim, In-Young Choi, Sung-Eun Yoo, Kyu-Yang Yi, Sun-Kyung Lee, Jee-Hee Suh, Nak-Jeong Kim, Byung-Ho Lee, Ho -Won Seo, Hwa-Sup Shin
  • Patent number: 6413983
    Abstract: The present invention relates to novel benzopyranyl heterocycle derivatives of the formula 1, process for preparation thereof and pharmaceutical use of the benzopyranyl heterocycle derivatives. The benzopyranyl heterocycle derivatives of the present invention can be used for protecting heart, brain, retina and neuronal cell from “ischemia-reperfusion” injury, treatment for diseases related to it and suppressing lipid peroxidation. Wherein R1, R2, R3, R4, n and * are each defined in specification.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: July 2, 2002
    Assignee: Dongbu Hannong Chemical Co. Ltd.
    Inventors: Sung-Eun Yoo, Sun Kyung Lee, Kyu Yang Yi, Nak Jeong Kim, Jee Hee Suh, Hwa Sup Shin, Byung Ho Lee, Ho Won Seo, Hong Lim, Sun-Ok Kim, Dongha Lee, Insun Cho, Miae Namgung, Dongsoo Jang
  • Patent number: 6323238
    Abstract: The present invention relates to novel benzopyranyl guanidine derivatives of the formula 1, process for preparation therof and pharmaceutical use of the benzopyranyl guanidine derivatives. The benzopyranyl guanidine derivatives of the present invention can be used for protecting heart, neuronal cell or brain damage, preserving organs, and also the benzopyranyl guanidine derivatives are pharmacologically useful for inhibiting NO generation, and for suppressing lipid peroxidation, angiogenesis or restenosis. Wherein R1, R2, R3, R4, R5, R6, n and * are each defined in specification.
    Type: Grant
    Filed: October 20, 2000
    Date of Patent: November 27, 2001
    Assignee: Dongbu Hannong Chemical Co., Ltd.
    Inventors: Sung-Eun Yoo, Kyu Yang Yi, Sun Kyung Lee, Nak-Jeong Kim, Jee Hee Suh, Young Sook Park, Sun Kyung Hwang, Hwa Sup Shin, Byung Ho Lee, Ho Won Seo, Hong Lim, Sun-Ok Kim, In Sun Cho, Miae Namgoong, Dongsoo Jang