Abstract: The present invention relates to a composition for preventing or treating diseases caused by mitochondrial dysfunction, containing, as an active ingredient, an isoquinoline derivative compound represented by chemical formula 1, or a pharmaceutically acceptable salt thereof, and does not induce mitochondrial damage, unlike conventional mitochondrial toxins such as CCCP, and specifically and excellently promotes the activity of mitophagy to alleviate mitochondrial disfunction, and thus can be effectively used in the treatment of diseases caused by mitochondrial dysfunction.

Abstract: The present invention relates to a method for prevention or treatment of metabolic disease, administering a composition containing bone morphogenetic protein 10 (BMP10) as an active ingredient, in which brown fat differentiation was promoted in the cells of BMP10-treated mouse embryonic mesenchymal cell line C3H10T1/T2, increased browning effects of stromal vascular fraction adipose stem cells isolated from subcutaneous adipose tissue was confirmed, and weight loss, improved insulin resistance, and changes in blood lipid levels were confirmed in a high-fat-diet-induced obese animal model. Therefore, the composition containing BMP10 as an active ingredient can be provided as a drug for the prevention or treatment of metabolic diseases, including obesity, diabetes, and dyslipidemia.