Abstract: Provided is a method for prevention and treatment of age-related macular degeneration through the suppression of cathepsin S expression, and retinal pigment epithelial cells in which cathepsin S is knocked down can be usefully used as a target for preventing or treating dry and wet age-related macular degenerations, in that the expression level of inflammatory cytokines and complement activity are reduced even under oxidative stress conditions, and the retinal pigment epithelial cells are not only more effective in suppressing complement activity than NF-?B inhibitors, but also suppress intracellular neovascularization and tube formation.

Abstract: The present invention relates to a composition for inhibiting angiogenesis, containing neo-N-methylsansalvamide (NMSSV), which is a cyclic pentadepsipeptide, as an effective ingredient, and specifically, since the NMSSV of the present invention has excellent activity which inhibits cell migration and tube formation associated with angiogenesis, and concentration-dependently inhibits angiogenesis induced by a vascular endothelial growth factor, it is expected that the NMSSV of the present invention may inhibit angiogenesis and be usefully used as a therapeutic agent for various diseases in which angiogenesis is abnormally regulated.

Abstract: The present invention relates to a composition for inhibiting angiogenesis, containing neo-N-methylsansalvamide (NMSSV), which is a cyclic pentadepsipeptide, as an effective ingredient, and specifically, since the NMSSV of the present invention has excellent activity which inhibits cell migration and tube formation associated with angiogenesis, and concentration-dependently inhibits angiogenesis induced by a vascular endothelial growth factor, it is expected that the NMSSV of the present invention may inhibit angiogenesis and be usefully used as a therapeutic agent for various diseases in which angiogenesis is abnormally regulated.