Patents by Inventor Jeewan Thakur

Jeewan Thakur has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Solid Oral Formulations and Crystalline Forms of an Inhibitor of Apoptosis Protein
    Publication number: 20180370960
    Abstract: The present disclosure relates to crystalline form of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, salts and hydrates thereof. This disclosure also relates to solid oral formulation of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, pharmaceutically acceptable salts, solvates (including hydrates) thereof, as well as methods of treatment using the same.
    Type: Application
    Filed: August 31, 2018
    Publication date: December 27, 2018
    Inventors: Jeewan THAKUR, Dong YANG, Lili FENG
  • Solid oral formulations and crystalline forms of an inhibitor of apoptosis protein
    Patent number: 10093665
    Abstract: The present disclosure relates to crystalline form of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, salts and hydrates thereof. This disclosure also relates to solid oral formulation of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, pharmaceutically acceptable salts, solvates (including hydrates) thereof, as well as methods of treatment using the same.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: October 9, 2018
    Assignee: Novartis AG
    Inventors: Jeewan Thakur, Dong Yang, Lili Feng
  • Pharmaceutical compositions comprising an aromatse inhibitors
    Patent number: 10064844
    Abstract: The present invention relates to low-dose pharmaceutical compositions comprising the aromatase inhibitor 4,4?-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, as the active ingredient in a suitable carrier. The present invention also relates to a process for their preparation and to their use as medicaments.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: September 4, 2018
    Assignee: MEREO BIOPHARMA 2 LIMITED
    Inventors: Ann Taylor, Lloyd B. Klickstein, Jeewan Thakur
  • Solid Oral Formulations and Crystalline Forms of an Inhibitor of Apoptosis Protein
    Publication number: 20170081319
    Abstract: The present disclosure relates to crystalline form of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, salts and hydrates thereof. This disclosure also relates to solid oral formulation of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, pharmaceutically acceptable salts, solvates (including hydrates) thereof, as well as methods of treatment using the same.
    Type: Application
    Filed: November 30, 2016
    Publication date: March 23, 2017
    Inventors: Jeewan Thakur, Dong Yang, Lili Feng
  • Pharmaceutical compositions comprising 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-y1)-1H-benzimidazol-2-y1]-1H-quinolin-2-one lactate monohydrate
    Patent number: 9545402
    Abstract: A pharmaceutical composition for oral administration comprising 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one monolactate monohydrate, a filler in an amount of 15 to 70% by weight, a disintegrant in an amount of less than 15% by weight, a glidant and/or a lubricant in an amount of 0.1 to 10% by weight wherein the amounts by weight are based on the total weight of the composition.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: January 17, 2017
    Assignee: Novartis AG
    Inventors: Jeewan Thakur, Zhihui Qiu
  • PHARMACEUTICAL COMPOSITIONS COMPRISING AN AROMATSE INHIBITORS
    Publication number: 20160346257
    Abstract: The present invention relates to low-dose pharmaceutical compositions comprising the aromatase inhibitor 4,4?-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, as the active ingredient in a suitable carrier. The present invention also relates to a process for their preparation and to their use as medicaments.
    Type: Application
    Filed: May 27, 2016
    Publication date: December 1, 2016
    Applicant: MEREO BIOPHARMA 2 LIMITED
    Inventors: Ann TAYLOR, Lloyd B. KLICKSTEIN, Jeewan THAKUR
  • Pharmaceutical compositions comprising an aromatse inhibitors
    Patent number: 9370505
    Abstract: The invention relates to low-dose pharmaceutical compositions comprising the aromatase inhibitor 4,4?-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, as the active ingredient in a suitable carrier. The present invention also relates to a process for their preparation and to their use as therapeutic agents.
    Type: Grant
    Filed: September 6, 2012
    Date of Patent: June 21, 2016
    Assignee: Mereo BioPharma 2 Limited
    Inventors: Ann Taylor, Lloyd B. Klickstein, Jeewan Thakur
  • PHARMACEUTICAL COMPOSITIONS COMPRISING AN AROMATSE INHIBITORS
    Publication number: 20140213622
    Abstract: The invention relates to low-dose pharmaceutical compositions comprising the aromatase inhibitor 4,4?[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, as the active ingredient in a suitable carrier. The present invention also relates to a process for their preparation and to their use as therapeutic agents.
    Type: Application
    Filed: September 6, 2012
    Publication date: July 31, 2014
    Inventors: Ann Taylor, Lloyd B. Klickstein, Jeewan Thakur
  • Solid Oral Formulations and Crystalline Forms of an Inhibitor of Apoptosis Protein
    Publication number: 20140093570
    Abstract: The present disclosure relates to crystalline form of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluorobenzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, salts and hydrates thereof. This disclosure also relates to solid oral formulation of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, pharmaceutically acceptable salts, solvates (including hydrates) thereof, as well as methods of treatment using the same.
    Type: Application
    Filed: December 3, 2013
    Publication date: April 3, 2014
    Applicant: Novartis AG
    Inventors: Jeewan Thakur, Dong Yang, Lili Feng
  • Solid oral formulations and crystalline forms of an inhibitor of apoptosis protein
    Patent number: 8623385
    Abstract: The present disclosure relates to crystalline form of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, salts and hydrates thereof. This disclosure also relates to solid oral formulation of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, pharmaceutically acceptable salts, solvates (including hydrates) thereof, as well as methods of treatment using the same.
    Type: Grant
    Filed: August 11, 2010
    Date of Patent: January 7, 2014
    Assignee: Novartis AG
    Inventors: Jeewan Thakur, Dong Yang, Lili Feng
  • Pharmaceutical compositions comprising 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-y1)-1H-benzimidazol-2-y1]-1H-quinolin-2-one lactate monohydrate
    Publication number: 20130090344
    Abstract: A pharmaceutical composition for oral administration comprising 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-quinolin-2-one monolactate monohydrate, a filler in an amount of 15 to 70% by weight, a disintegrant in an amount of less than 15% by weight, a glidant and/or a lubricant in an amount of 0.1 to 10% by weight wherein the amounts by weight are based on the total weight of the composition.
    Type: Application
    Filed: June 29, 2011
    Publication date: April 11, 2013
    Applicant: Novartis AG
    Inventors: Jeewan Thakur, Zhihui Qiu
  • SOLID ORAL FORMULATIONS AND CRYSTALLINE FORMS OF AN INHIBITOR OF APOPTOSIS PROTEIN
    Publication number: 20120128742
    Abstract: The present disclosure relates to crystalline form of (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, salts and hydrates thereof. This disclosure also relates to solid oral formulation of (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, pharmaceutically acceptable salts, solvates (including hydrates) thereof, as well as methods of treatment using the same.
    Type: Application
    Filed: August 11, 2010
    Publication date: May 24, 2012
    Inventors: Jeewan Thakur, Dong Yang, Lili Feng