Abstract: This invention relates to a pharmaceutical composition comprising 5-chloro-N4-[2-(dimethylphosphoryl)phenyl]-N2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}pyrimidine-2,4-diamine as the active pharmaceutical ingredient, and therapeutic uses of the pharmaceutical formulation. In particular, the invention is directed to tablets comprising the pharmaceutical composition, methods of preparing the tablets, and therapeutic uses thereof.

Abstract: An endgate comprising a mounting bracket adapted to be attached to a screed assembly, a pivoting plate adapted to be pivotally attached to the mounting bracket, a sliding plate, a pavement contacting surface and a support adapted to be pivotally moved with the pivoting plate, a means for applying force to the pavement contacting surface disposed between the support and the sliding plate, a first adjustment means adapted to adjust the amount of force applied by the means for applying force to the pavement contacting surface and a second adjustment means adapted to adjust the angle of the pavement contacting surface. A method comprising providing such an endgate, adjusting the angle of the pavement contacting surface and adjusting the amount of force applied by the means for applying force to the pavement contacting surface.