Patents by Inventor Jeff D. Debad
Jeff D. Debad has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140378347Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.Type: ApplicationFiled: September 5, 2014Publication date: December 25, 2014Applicant: Meso Scale Technologies, LLCInventors: Jeff D. Debad, Eli N. Glezer, Sudeep M. Kumar
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Patent number: 8852922Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.Type: GrantFiled: August 30, 2011Date of Patent: October 7, 2014Assignee: Meso Scale Technologies, LLCInventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
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Patent number: 8808627Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.Type: GrantFiled: November 11, 2010Date of Patent: August 19, 2014Assignee: Meso Scale Technologies, LLCInventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
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Patent number: 8790578Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.Type: GrantFiled: April 4, 2012Date of Patent: July 29, 2014Assignee: Meso Scale Technologies, LLCInventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
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Publication number: 20140151224Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.Type: ApplicationFiled: February 3, 2014Publication date: June 5, 2014Applicant: Meso Scale Technologies, LLCInventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
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Patent number: 8641986Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.Type: GrantFiled: October 2, 2008Date of Patent: February 4, 2014Assignee: Meso Scale Technologies, LLCInventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
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Publication number: 20130172431Abstract: Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention. Also described are methods for monitoring patient's treatment by administering tests of the present invention. Also described are methods for evaluating the effectiveness of a drug or a drug candidate by administering tests of the present invention to samples from patients, animal models, and cell cultures treated with a drug or a drug candidate. Also disclosed are methods for determining the usefulness of analytes, e.g. cytokines, for acting as diagnostic and monitoring markers for inflammatory bowel disease in the various methods of the invention.Type: ApplicationFiled: February 25, 2013Publication date: July 4, 2013Applicant: Meso Scale Technologies, LLCInventors: Jeff D. Debad, Eli N. Glezer, Sudeep M. Kumar
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Patent number: 8343526Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.Type: GrantFiled: October 18, 2011Date of Patent: January 1, 2013Assignee: Meso Scale Technologies, LLCInventors: Mark A. Billadeau, Jeff D. Debad, Eli N. Glezer, Jonathan K. Leland, Charles A. Wijayawardhana
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Patent number: 8298834Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.Type: GrantFiled: August 31, 2010Date of Patent: October 30, 2012Assignee: Meso Scale Technologies, L.L.C.Inventors: Eli N. Glezer, Bandele Jeffrey-Coker, Jeff D. Debad, Sudeep M. Kumar, George Sigal, Gisbert Spieles, Michael Tsionsky, Michael Warnock
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Patent number: 8273566Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.Type: GrantFiled: July 6, 2010Date of Patent: September 25, 2012Assignee: Meso Scale Technologies, LLCInventors: Mark A. Billadeau, Jeff D. Debad, Eli N. Glezer, Jonathan K. Leland, Charles A. Wijayawardhana
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Publication number: 20120190590Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.Type: ApplicationFiled: April 4, 2012Publication date: July 26, 2012Applicant: MESO SCALE TECHNOLOGIES, LLCInventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
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Publication number: 20120190591Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.Type: ApplicationFiled: April 4, 2012Publication date: July 26, 2012Applicant: MESO SCALE TECHNOLOGIES, LLCInventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
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Patent number: 8192926Abstract: The present invention is directed to methods for extracting markers from biological samples, and to systems, devices, kits and reagents for use in such methods. The invention is also to methods, kits, reagents and compositions for measuring a plurality of different organism types in a sample. One of the specific advantages of the present invention is the ability to simultaneously extract more than one microorganism or viral particle marker in one volume from a single sample containing a complex biological matrix.Type: GrantFiled: May 19, 2006Date of Patent: June 5, 2012Assignee: Meso Scale Technologies LLCInventors: Jeff D. Debad, Cindy V. Ly
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Publication number: 20120055809Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.Type: ApplicationFiled: August 30, 2011Publication date: March 8, 2012Applicant: Meso Scale Technologies, LLCInventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
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Publication number: 20120034645Abstract: Disclosed are methods for conducting assays of samples, such as whole blood, that may contain cells or other particulate matter. Also disclosed are systems, devices, equipment, kits and reagents for use in such methods. One advantage of certain disclosed methods and systems is the ability to rapidly measure the concentration of an analyte of interest in blood plasma from a whole blood sample without blood separation and hematocrit correction.Type: ApplicationFiled: October 18, 2011Publication date: February 9, 2012Applicant: MESO SCALE TECHNOLOGIES, LLC.Inventors: Mark A. Billadeau, Jeff D. Debad, Eli N. Glezer, Jonathan K. Leland, Charles A. Wijayawardhana
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Patent number: 8012745Abstract: Assay modules, preferably assay cartridges, are described as are reader apparatuses which may be used to control aspects of module operation. The modules preferably comprise a detection chamber with integrated electrodes that may be used for carrying out electrode induced luminescence measurements. Methods are described for immobilizing assay reagents in a controlled fashion on these electrodes and other surfaces. Assay modules and cartridges are also described that have a detection chamber, preferably having integrated electrodes, and other fluidic components which may include sample chambers, waste chambers, conduits, vents, bubble traps, reagent chambers, dry reagent pill zones and the like. In certain preferred embodiments, these modules are adapted to receive and analyze a sample collected on an applicator stick.Type: GrantFiled: October 2, 2008Date of Patent: September 6, 2011Assignee: Meso Scale Technologies, LLCInventors: Eli N. Glezer, Jonathan K. Leland, Mark A. Billadeau, Joseph M. Leginus, Bandele Jeffrey-Coker, Jeff D. Debad, Koustubh A. Phalnikar, Sriram Jambunathan
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Publication number: 20110203924Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.Type: ApplicationFiled: November 11, 2010Publication date: August 25, 2011Applicant: MESO SCALE TECHNOLOGIES, LLCInventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
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Publication number: 20110105354Abstract: Multiplexed test measurements are conducted using an assay module having a plurality of assay domains. In preferred embodiments, these measurements are conducted in assay modules having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.Type: ApplicationFiled: December 23, 2010Publication date: May 5, 2011Applicant: MESO SCALE TECHNOLOGIES, LLCInventors: Eli N. Glezer, Kent Johnson, Michael Tsionsky, John H. Kenten, Jeff D. Debad, Robert M. Umek, Paula Denney Eason, Hans Biebuyck, Jacob N. Wohlstadter, James Wilbur, George Sigal, Niranjan Y. Sardesai
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Publication number: 20110059870Abstract: Luminescence test measurements are conducted using an assay module having integrated electrodes with a reader apparatus adapted to receive assay modules, induce luminescence, preferably electrode induced luminescence, in the wells or assay regions of the assay modules and measure the induced luminescence.Type: ApplicationFiled: November 11, 2010Publication date: March 10, 2011Applicant: MESO SCALE TECHNOLOGIES, LLCInventors: Jacob N. Wohlstadter, Eli Glezer, James Wilbur, George Sigal, Kent Johnson, Charles Clinton, Alan Kishbaugh, Bandele Jeffrey-Coker, Jeff D. Debad, Alan B. Fischer
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Publication number: 20110015091Abstract: We describe assay modules (e.g., assay plates, cartridges, multi-well assay plates, reaction vessels, etc.), processes for their preparation, and method of their use for conducting assays. Reagents may be present in free form or supported on solid phases including the surfaces of compartments (e.g., chambers, channels, flow cells, wells, etc.) in the assay modules or the surface of colloids, beads, or other particulate supports. In particular, dry reagents can be incorporated into the compartments of these assay modules and reconstituted prior to their use in accordance with the assay methods. A desiccant material may be used to maintain and stabilize these reagents in a dry state.Type: ApplicationFiled: August 31, 2010Publication date: January 20, 2011Applicant: Meso Scale Technologies, L.L.C.Inventors: Eli N. GLEZER, Bandele JEFFREY-COKER, Jeff D. DEBAD, Sudeep M. KUMAR, George SIGAL, Gisbert SPIELES, Michael TSIONSKY, Michael WARNOCK