Abstract: The disclosure provides a pair of isolated biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1, wherein the pair of biomarkers exhibits a change in reversal value between pregnant females at risk for pre-term birth and term controls. Also provided is a method of determining probability for preterm birth in a pregnant female, the method comprising measuring in a biological sample obtained from the pregnant female a reversal value for at least one pair of biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1 to determine the probability for preterm birth in the pregnant female.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand with open ends around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system also includes means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The preferred embodiment of the catheter includes structures which provide radial and lateral support to the guide tubes so that the guide tubes open uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: A catheter device for implanting a medical implant such as a prosthetic heart valve has a handle configured to control/steer multiple sheaths of the catheter device. A handle includes a grip portion, a rotatable deployment knob and a traveler. An outer sheath is connected to the traveler and the deployment knob is operatively connected to the traveler such that the traveler and thereby the outer sheath are moved along the longitudinal axis with respect to the inner sheath. The handle includes a rotatable axial positioning knob and a rotatable deflection knob. The deployment knob is arranged proximally to the axial positioning knob.

Abstract: Systems and methods for folding and retaining upper flaps of a box are disclosed. The system includes a conveyor system configured to advance the box at least partially through the system. A flap folding assembly is configured to fold the upper flaps of the box to an open or outwardly folded configuration. The upper flaps are folded outwardly and down towards outer sidewall surfaces of the box in the folded configuration. A bander assembly is configured to apply a band or other restraint to the upper flaps of the box to retain the upper flaps in the folded configuration.

Abstract: The present invention relates to a multipurpose drill system, the multipurpose drill system comprising: a drilling rig adapted to drive a drilling assembly; and two or more power sources, wherein at least one of the two or more power sources is a high pressure power source, wherein the drilling assembly is adapted to be in communication with either or both of the two or more power sources.

Abstract: An autonomous vehicle includes one or more sensors for detecting an object in an environment surrounding the autonomous vehicle and a vehicle computing system comprising one or more processors receiving canonical route data associated with at least one canonical route, and controlling travel of the autonomous vehicle based on sensor data from the one or more sensors and the canonical route data associated with the at least one canonical route. The at least one canonical route comprises at least one roadway connected with another roadway in a plurality of roadways in a geographic location that satisfies at least one route optimization function derived based on trip data associated with one or more traversals of the plurality of roadways in a geographic location by one or more autonomous vehicles.

Abstract: An intravascular catheter for peri-vascular and/or peri-urethral tissue ablation includes multiple needles advanced through supported guide tubes which expand around a central axis to engage the interior surface of the wall of the renal artery or other vessel of a human body allowing the injection an ablative fluid for ablating tissue, and/or nerve fibers in the outer layer or deep to the outer layer of the vessel, or in prostatic tissue. The system may also include a means to limit and/or adjust the depth of penetration of the ablative fluid into and beyond the tissue of the vessel wall. The catheter may also include structures which provide radial and/or lateral support to the guide tubes so that the guide tubes expand uniformly and maintain their position against the interior surface of the vessel wall as the sharpened injection needles are advanced to penetrate into the vessel wall.

Abstract: Example fluid collection systems and methods of collecting fluid are described. The fluid collection system includes a fluid collection device and one or more straps secured or securable to the fluid collection device. The one or more straps are configured to wrap around the user to secure the fluid collection device adjacent to the urethra of the user.

Abstract: Example fluid collection systems and methods of use are described. The fluid collection system includes a garment and a fluid collection device. The garment is configured to be worn on a pelvis of a user, and includes at least a crotch portion having an inner surface and at least one of a strap partially defining a through hole between the strap and the inner surface or a pocket on the inner surface of the crotch portion. The at least one of the strap or the pocket are positioned on the crotch portion of the garment and the fluid collection device is sized to position the opening and the fluid permeable body proximate to a urethra of the user.

Abstract: Systems and methods for folding and retaining upper flaps of a box are disclosed. The system includes a conveyor system configured to advance the box at least partially through the system. A flap folding assembly is configured to fold the upper flaps of the box to an open or outwardly folded configuration. The upper flaps are folded outwardly and down towards outer sidewall surfaces of the box in the folded configuration. A bander assembly is configured to apply a band or other restraint to the upper flaps of the box to retain the upper flaps in the folded configuration.

Abstract: An example fluid collection assembly includes a fluid impermeable barrier defining at least one opening, a chamber in fluid communication with the at least one opening, and at least one fluid outlet. The fluid collection assembly also includes at least one porous material (e.g., at least one wicking material) disposed in the chamber. The fluid collection assembly also includes at least one conduit attached to the fluid outlet. Further, the fluid collection assembly includes one or more leak prevention features.

Abstract: A system, method and computer readable storage medium that receives traffic/packets from external devices attempting to access protected devices in a protected network. A determination is made to whether a received packet belongs to one of a plurality of packet classifications. Each packet classification indicative of different classes of IP traffic. Countermeasures are applied to a received packet to prevent attack upon the protected devices. Applying a countermeasure to a received packet determined to belong to one of the plurality of packet classifications includes countermeasure modification/selection contingent upon the determined packet classification for the received packet.

Abstract: A system, method and computer readable storage medium that receives traffic/packets from external devices attempting to access protected devices in a protected network. A determination is made to whether a received packet belongs to one of a plurality of packet classifications. Each packet classification indicative of different classes of IP traffic. Countermeasures are applied to a received packet to prevent attack upon the protected devices. Applying a countermeasure to a received packet determined to belong to one of the plurality of packet classifications includes countermeasure modification/selection contingent upon the determined packet classification for the received packet.

Abstract: A plaster collar assembly having a first ring, a second ring secured to the first ring, and a mechanism arranged at an outer periphery of at least one of the rings for axially displacing the first and second rings during rotation of the secured rings relative to each other.

Abstract: A plaster collar assembly having a first ring, a second ring secured to the first ring, and a mechanism arranged at an outer periphery of at least one of the rings for axially displacing the first and second rings during rotation of the secured rings relative to each other.

Abstract: A plaster collar assembly having a first ring, a second ring secured to the first ring, and a mechanism arranged at an outer periphery of at least one of the rings for axially displacing the first and second rings during rotation of the secured rings relative to each other.