Abstract: An apposition device having a first elongate element movably coupled with a second elongate element. The second elongate element is deployable distal to the structures to be apposed, in a position transverse to the first elongate element. The first elongate element may be pulled to pull the second elongate element to move the structures into apposition. A third element may be positioned proximal to the structures to hold the structures in apposition. The third element may be a ratcheting element fixable in place with respect to the first elongate element. The apposition device may be deployed with a fine gauge needle. The second elongate element may be deployed from a side port in the needle facilitating deployment, and/or movement of the second elongate element with respect to the first elongate element and into a deployment configuration. Such arrangement may allow control of the first elongate element independent of the needle.

Abstract: Devices, systems, and methods for coupling tubing to a fluid reservoir to provide liquid to an endoscope system. A manifold for coupling to a fluid reservoir and a tubing assembly may include first portion interfacing with an interior of the fluid reservoir and a second portion configured to interface with tubing to be fluidly coupled to the interior of the reservoir. The first portion may include one or more openings to allow gas to pass into the fluid reservoir and liquid to pass out of the fluid reservoir. The second portion may include one or more ports for connecting to tubing that brings gas to the fluid reservoir and receives liquid from the fluid reservoir. The manifold may include a valve that selectively allows gas to pass into the fluid reservoir.

Abstract: Devices, systems, and methods for connecting tubes to an endoscope. A connector for connecting tubing, such as gas/lens wash tubing, to fluid ports of an endoscope may include a first end that couples with the tubing and a second end for engaging fluid ports of an endoscope. The connector may have a stabilizing component configured to facilitate securing the second end to the endoscope. In some cases, the connector may include a device coupling member configured to couple to the endoscope and a core structure adding stability to the device coupling member and configured to couple to the tubing. In some cases, the stabilizing component may include an actuator and a retention component that adjusts in response to actuation of the actuator.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of Follistatin-related protein 3, Basigin, Cathepsin B, and Tenascin as diagnostic and prognostic biomarker assays in renal injuries.

Abstract: A medical device comprising a shaft, a handle including a proximal portion and a distal portion, wherein the distal portion is fixed to a proximal portion of the shaft, and a channel extending from the handle into the shaft, wherein the channel includes a proximal channel and a distal channel, the proximal channel being rotatable relative to the distal channel and aligned with the distal channel throughout rotation of the proximal channel, wherein the proximal portion includes the proximal channel and the distal portion includes the distal channel, wherein the distal portion is rotatable relative to the proximal portion of the handle, and the shaft is configured to rotate with the distal portion of the handle.

Abstract: Methods and systems for redirecting a flow of air/gas to flush fluid channels. An illustrative container and tube set for redirecting a flow of air may include a container, a water supply tube including a first lumen extending therethrough, a gas supply tube including a second lumen extending therethrough, a manifold including a first inlet for receiving air, a second inlet for receiving fluid from the container, a first air outlet, and a second fluid outlet, and a valve positioned within the manifold. When the valve is in a first configuration, the first inlet is in fluid communication with the first air outlet, and the second inlet is in fluid communication the second fluid outlet and when the valve is in a second configuration, the first inlet is in fluid communication with the second fluid outlet.

Abstract: Methods and systems for refilling a container during an endoscopic procedure. An illustrative container may comprise a container configured to contain a fluid within a first receptacle thereof, the container movable between a collapsed storage configuration and an expanded use configuration, a lens water supply tube including a first lumen extending therethrough, the first lumen is in fluid communication with the first receptacle of the container, a gas supply tube including a second lumen extending therethrough, the second lumen is in operative fluid communication with the first receptacle, and a port positioned adjacent to the top portion of the container. The port may be configured to be in selective fluid communication with the first receptacle of the container.

Abstract: Methods and systems for refilling a container during an endoscopic procedure. An illustrative container may comprise a container configured to contain a fluid, a water supply tube including a first end, a second end, and a first lumen extending therethrough and in fluid communication with the bottom portion of the container, a gas supply tube including a first end, a second end, and a second lumen extending therethrough and in operative fluid communication with container, a manifold configured to couple the water supply tube and the gas supply tube to the container and including a first end positioned interior to the container and a second end positioned exterior to the container, and a port positioned adjacent to the top portion of the container. The port may be configured to be in selective fluid communication with an interior of the container.

Abstract: A system for controlling the flow of fluid through a medical device may include a medical device having a lumen that extends to a distal end of the medical device; a fluid source configured to supply fluid having a positive pressure to the lumen of the medical device; and a flow controller configured to apply a negative pressure to the fluid within the lumen, wherein the flow controller is triggered to apply the negative pressure upon a lowering of the positive pressure from the fluid source.

Abstract: Medical devices and methods for using medical devices are disclosed. Example fluid reservoirs and tube sets arranged and configured to couple to an endoscope for use in an endoscopic procedure are disclosed. An example fluid reservoir and tube set includes a fluid reservoir configured to contain a fluid, a fluid supply tube configured to be coupled to the endoscope and having a lumen extending therethrough, wherein the lumen is in fluid communication with the fluid reservoir and a first backflow prevention mechanism coupled to the fluid supply tube, the first backflow prevention mechanism configured to permit fluid to flow through the fluid supply line from the fluid reservoir to the endoscope and to prevent fluid from flowing back through the fluid supply tube from the endoscope to the fluid reservoir.

Abstract: A medical device may include a shaft extending from a proximal end toward a distal end, the shaft including a lumen extending from the proximal end toward the distal end; a first stapling head at the distal end, the first stapling head configured to contain one or more staples, and the first stapling head having a block disposed within, and movable relative to, the first stapling head; a second stapling head at the distal end; and a pushing element extending through the lumen, the pushing element being movable from a first position to a second position, wherein transition of the pushing element from the first position to the second position urges the block to move toward second stapling head to deploy the one or more staples.

Abstract: A medical device comprising a shaft, a handle including a proximal portion and a distal portion, wherein the distal portion is fixed to a proximal portion of the shaft, and a channel extending from the handle into the shaft, wherein the channel includes a proximal channel and a distal channel, the proximal channel being rotatable relative to the distal channel and aligned with the distal channel throughout rotation of the proximal channel, wherein the proximal portion includes the proximal channel and the distal portion includes the distal channel, wherein the distal portion is rotatable relative to the proximal portion of the handle, and the shaft is configured to rotate with the distal portion of the handle.

Abstract: A system for controlling the flow of fluid through a medical device may include a medical device having a lumen that extends to a distal end of the medical device; a fluid source configured to supply fluid having a positive pressure to the lumen of the medical device; and a flow controller configured to apply a negative pressure to the fluid within the lumen, wherein the flow controller is triggered to apply the negative pressure upon a lowering of the positive pressure from the fluid source.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Thymic stromal lymphopoietin, Vascular endothelial growth factor receptor 1, C—C motif chemokine 1, C—C motif chemokine 17, C—C motif chemokine 21, C—C motif chemokine 27, FLT-3 Ligand, Immunoglobulin G subclass 3, Interleukin-1 receptor type I, Interleukin-20, Interleukin-29, Interleukin-7, Platelet-derived growth factor A/B dimer, Platelet-derived growth factor A/A dimer, and MMP9:TIMP2 complex as diagnostic and prognostic biomarkers in renal injuries.

Abstract: A medical device may include a shaft extending from a proximal end toward a distal end, the shaft including a lumen extending from the proximal end toward the distal end; a first stapling head at the distal end, the first stapling head configured to contain one or more staples, and the first stapling head having a block disposed within, and movable relative to, the first stapling head; a second stapling head at the distal end; and a pushing element extending through the lumen, the pushing element being movable from a first position to a second position, wherein transition of the pushing element from the first position to the second position urges the block to move toward second stapling head to deploy the one or more staples.

Abstract: Disclosed are methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury The methods use assays that detect one or more markers selected from the group consisting of Cytoplasmic aspartate aminotransferase, soluble Tumor necrosis factor receptor superfamily member 5, soluble CD40 Ligand, soluble C-X-C Motif chemokine 16, SIOO-AI2, Eotaxin, soluble E-selectin, Fibronectin, Granulocyte colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor, Heparin-binding growth factor 2, soluble Hepatocyte growth factor receptor, Interleukin-I receptor antagonist, Interleukin-I beta, lnterleukun-10, lnterieukun-15, lnterieukun-3, Myeloperoxidase, Nidogen-I, soluble Oxidized low-density lipoprotein receptor I, Pappalysin-I, soluble P-selectin glycoprotein ligand I, Antileukoproteinase, soluble Kit ligand, Tissue inhibitor of metalloproteinasel, Tissue inhibitor of metalloproteinase 2, soluble Tumor n

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Coagulation factor VII, CA 19-9, Insulin-like growth factor-binding protein 7, C—X—C motif chemokine 6, and C—C motif chemokine 13 as diagnostic and prognostic biomarkers in renal injuries.

Abstract: A system for tracking a medical device, the system comprising a support having a channel extending therethrough, the channel being defined circumferentially by a surface, at least one encoder configured to track movement of a medical device through the channel, and one or more processors configured to receive input from the at least one encoder, receive an instruction from a user to store a zero position of the medical device relative to the channel, determine relative movement of the medical device from the zero position, and communicate the relative movement of the medical device from the zero position.

Abstract: The present disclosure relates generally to the field of medical devices and establishing fluid communication between body lumens. In particular, the present disclosure relates to devices and methods for establishing a controlled flow or access passage between body lumens.