Abstract: A system for tracking a medical device, the system comprising a support having a channel extending therethrough, the channel being defined circumferentially by a surface, at least one encoder configured to track movement of a medical device through the channel, and one or more processors configured to receive input from the at least one encoder, receive an instruction from a user to store a zero position of the medical device relative to the channel, determine relative movement of the medical device from the zero position, and communicate the relative movement of the medical device from the zero position.

Abstract: The present disclosure relates generally to medical devices and procedures for placement of a medical device between adjacent tissue structures. In particular, the present disclosure relates to endoscopic systems and methods for preventing or minimizing movement between tissue walls to facilitate placement of a stent therebetween.

Abstract: The present disclosure relates generally to medical devices and procedures for placement of a medical device between adjacent tissue structures. In particular, the present disclosure relates to endoscopic systems and methods for preventing or minimizing movement between tissue walls to facilitate placement of a stent therebetween.

Abstract: The present disclosure relates generally to apparatus, devices, and methods for increasing force distribution at a suture-tissue interface. In some embodiments, a tissue suturing device may include a deployment device and a plurality of tissue supports deployable from the deployment device towards a target tissue. The plurality of tissue supports may each include a central opening for receiving a suture during deployment.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of C-C motif chemokine 16, C-C motif chemokine 14, and Tyrosine-protein kinase receptor UFO as diagnostic and prognostic biomarker assays in renal injuries.

Abstract: A fastening device may comprise a flexible longitudinal body including a central longitudinal axis and a distal end; an anvil extending distally from the distal end of longitudinal body; and a distal body extending distally from the distal end of the longitudinal body. The distal body may be configured to removably receive a cartridge having a plurality of fasteners. At least one of the anvil and the distal body may be flexible and may have a first configuration with a distal portion of the at least one of the anvil and the distal body extending radially outward from the central longitudinal axis and a second configuration with the distal portion closer to the central longitudinal axis than in the first configuration.

Abstract: The present disclosure relates generally to apparatus, devices, and methods for increasing force distribution at a suture-tissue interface. In some embodiments, a tissue suturing device may include a deployment device and a plurality of tissue supports deployable from the deployment device towards a target tissue. The plurality of tissue supports may each include a central opening for receiving a suture during deployment.

Abstract: The present disclosure relates generally to ligators, actuation devices, and methods for deploying ligation bands around a portion of tissue, utilizing an endoscope for suction, visualization, and support. In some embodiments, a ligator may include an elongate member having a lumen, and a ligating band dispenser extending from a distal end of the elongate member. The ligating band dispenser may include a cap and at least one ligating band on the cap. The ligator may further include an actuation device extending around the elongate member, wherein the actuation device includes a body, and a bobbin coupled to the body by support arms. A suture may be coupled between the bobbin and the at least one ligating band, wherein rotation of the bobbin draws the suture towards a proximal end of the elongate member to deploy the at least one ligating band from the cap.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a measured urine concentration of one or more of TIMP2 and IGFBP7 in combination with one or more of a measured serum creatinine and a measured urine output, which results are correlated to the renal status of the subject, and can be used for diagnosis, prognosis, risk stratification, staging, monitoring, categorizing and determination of further diagnosis and treatment regimens in subjects suffering or at risk of suffering from an injury to renal function, reduced renal function, and/or acute renal failure.

Abstract: Devices, systems, and methods for delivering and deploying an implantable medical device with respect to a target site along a tissue wall by applying suction to draw the tissue wall to a delivery and deployment device, such as to a tissue-penetrating end of the delivery and deployment device. An additional implantable device may be deployed distal to the tissue wall, such as to facilitate manipulation of the distal wall. At least a portion of the first implantable medical device may be deployed with respect to the additional implantable medical device, such as within a lumen of the additional implantable medical device. The implantable medical device may shift from a delivery configuration to an expanded deployed configuration, and at least a portion of the implantable medical device may expand beyond the deployed configuration after deployment device to further resist migration of the implantable medical device from the target site.

Abstract: A locator device and system with an expandable element facilitating imaging of the locator device at a target site at a first anatomical location within a patient from a remote second anatomical location within the patient. The locator device may be formed of a material capable of being imaged from the remote second anatomical location. The locator device may be expandable to contact the interior of the anatomical structure at the first anatomical location to facilitate deployment and to resist movement with respect thereto. The locator device may be separable from the delivery system used to deliver the locator device and left in place at the target site. The locator device may expand the anatomical structure at the first anatomical location to facilitate imaging of such structure from the remote second anatomical structure. In some instances, the locator device may be returned to the delivery configuration and removed from the target site.

Abstract: Methods and systems for controlling leaks from a tubing set of an endoscope system during equipment changeouts. An illustrative connector arranged and configured to couple a tube set to an endoscope may comprise a housing comprising a first fluid inlet, a second fluid inlet, a first fluid outlet in selective fluid communication with the first fluid inlet, a second fluid outlet in fluid communication with the second fluid inlet, and a flow control mechanism configured to selectively fluidly couple the first fluid outlet with the first fluid inlet.

Abstract: An apposition device having a first elongate element movably coupled with a second elongate element. The second elongate element is deployable distal to the structures to be apposed, in a position transverse to the first elongate element. The first elongate element may be pulled to pull the second elongate element to move the structures into apposition. A third element may be positioned proximal to the structures to hold the structures in apposition. The third element may be a ratcheting element fixable in place with respect to the first elongate element. The apposition device may be deployed with a fine gauge needle. The second elongate element may be deployed from a side port in the needle facilitating deployment, and/or movement of the second elongate element with respect to the first elongate element and into a deployment configuration. Such arrangement may allow control of the first elongate element independent of the needle.

Abstract: Devices, systems, and methods for coupling tubing to a fluid reservoir to provide liquid to an endoscope system. A manifold for coupling to a fluid reservoir and a tubing assembly may include first portion interfacing with an interior of the fluid reservoir and a second portion configured to interface with tubing to be fluidly coupled to the interior of the reservoir. The first portion may include one or more openings to allow gas to pass into the fluid reservoir and liquid to pass out of the fluid reservoir. The second portion may include one or more ports for connecting to tubing that brings gas to the fluid reservoir and receives liquid from the fluid reservoir. The manifold may include a valve that selectively allows gas to pass into the fluid reservoir.

Abstract: Devices, systems, and methods for connecting tubes to an endoscope. A connector for connecting tubing, such as gas/lens wash tubing, to fluid ports of an endoscope may include a first end that couples with the tubing and a second end for engaging fluid ports of an endoscope. The connector may have a stabilizing component configured to facilitate securing the second end to the endoscope. In some cases, the connector may include a device coupling member configured to couple to the endoscope and a core structure adding stability to the device coupling member and configured to couple to the tubing. In some cases, the stabilizing component may include an actuator and a retention component that adjusts in response to actuation of the actuator.

Abstract: A medical device comprising a shaft, a handle including a proximal portion and a distal portion, wherein the distal portion is fixed to a proximal portion of the shaft, and a channel extending from the handle into the shaft, wherein the channel includes a proximal channel and a distal channel, the proximal channel being rotatable relative to the distal channel and aligned with the distal channel throughout rotation of the proximal channel, wherein the proximal portion includes the proximal channel and the distal portion includes the distal channel, wherein the distal portion is rotatable relative to the proximal portion of the handle, and the shaft is configured to rotate with the distal portion of the handle.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of Follistatin-related protein 3, Basigin, Cathepsin B, and Tenascin as diagnostic and prognostic biomarker assays in renal injuries.

Abstract: Methods and systems for refilling a container during an endoscopic procedure. An illustrative container may comprise a container configured to contain a fluid, a water supply tube including a first end, a second end, and a first lumen extending therethrough and in fluid communication with the bottom portion of the container, a gas supply tube including a first end, a second end, and a second lumen extending therethrough and in operative fluid communication with container, a manifold configured to couple the water supply tube and the gas supply tube to the container and including a first end positioned interior to the container and a second end positioned exterior to the container, and a port positioned adjacent to the top portion of the container. The port may be configured to be in selective fluid communication with an interior of the container.

Abstract: Methods and systems for refilling a container during an endoscopic procedure. An illustrative container may comprise a container configured to contain a fluid within a first receptacle thereof, the container movable between a collapsed storage configuration and an expanded use configuration, a lens water supply tube including a first lumen extending therethrough, the first lumen is in fluid communication with the first receptacle of the container, a gas supply tube including a second lumen extending therethrough, the second lumen is in operative fluid communication with the first receptacle, and a port positioned adjacent to the top portion of the container. The port may be configured to be in selective fluid communication with the first receptacle of the container.