Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble Advanced glycosylation end product-specific receptor, Bactericidal permeability-increasing protein, Interleukin 12, Fibroblast growth factor 23, Vitamin K-dependent protein C, and Intestinal fatty acid-binding protein as diagnostic and prognostic biomarkers in renal injuries.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble Advanced glycosylation end product-specific receptor, Bactericidal permeability-increasing protein, Interleukin 12, Fibroblast growth factor 23, and Intestinal fatty acid-binding protein as diagnostic and prognostic biomarkers in renal injuries.

Abstract: A phase-controlled power supply is disclosed. The power supply includes a power conditioner with an input configured to connect to an external source of electrical power, the power conditioner being configured to provide conditioned power on its output. The power supply also includes a transformer having a primary winding and a secondary winding, and a switching module coupled between the output of the power conditioner and to the primary winding of the transformer. The switching module has two modes of operation and a control signal input configured to accept a first control signal. The switching module includes a switching element configured to connect the power conditioner output to the primary winding of the transformer. The switching module operates in the first mode when the first control signal is in a first state, switching the first switching element at a first frequency and first duty cycle.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Clusterin, Heart-type fatty acid binding protein, Hepatocyte growth factor, Interferon gamma, Interleukin-12 subunit beta, Interleukin-16, Interleukin-2, 72 kDa type IV collagenase, Matrix metalloproteinase-9, Midkine, and Serum amyloid P-component as diagnostic and prognostic biomarkers in renal injuries.

Abstract: An implantable port for accessing internal body structures, the port comprises a proximal housing including an opening providing access to an interior of the port and a distal housing adapted for assembly with the proximal housing, the distal housing including a reservoir which, when the distal housing is mated with the proximal housing is in fluid communication with the opening of the proximal housing in combination with a radiopaque element in one of the proximal and distal housings, a shape of the radiopaque element identifying, when imaged, a structural characteristic of the port not otherwise identifiable visually.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of Epidermal growth factor, Complement C3, Interleukin-4, Interleukin-1 alpha, Tubulointerstitial nephritis antigen, Transforming growth factor beta-1, Bone morphogenetic protein 7, Osteopontin, Netrin-1, and Growth-regulated alpha protein as diagnostic and prognostic biomarkers in renal injuries.

Abstract: The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble CD44 antigen, Angiopoietin-1, soluble Angiopoietin-1 receptor, C—X—C chemokine motif 5, soluble Endoglin, soluble Tumor-associated calcium signal transducer 1, Erythropoietin, soluble Fractalkine, Heme oxygenase 1, soluble Interleukin-1 receptor type II, soluble Interleukin-6 receptor subunit-alpha, Lymphotactin, Lymphotoxin-alpha, Stromelysin-1, C—C motif chemokine 22, C—C motif chemokine 5, and Thrombospondin-1 as diagnostic and prognostic biomarkers in renal injuries.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of soluble p-selectin, protein NOV homolog, soluble epidermal growth factor receptor, netrin-4, haptoglobin, heat shock protein beta-1, alpha-1-antitrypsin, leukocyte elastase, soluble tumor necrosis factor receptor superfamily member 6, soluble tumor necrosis factor ligand superfamily member 6, soluble intercellular adhesion molecule 2, active caspase-3, and soluble platelet endothelial cell adhesion molecule as diagnostic and prognostic biomarkers in renal injuries.

Abstract: The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more markers selected from the group consisting of cytochrome c and insulin-like growth factor IA as diagnostic and prognostic biomarkers in renal injuries.

Abstract: The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.

Abstract: The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.

Abstract: An apparatus for facilitating fluid flow between an internal body structure and a device external to the body comprises a housing having proximal and distal chambers separated from one another by a wall and fluidly connected to proximal port and distal ports. The wall includes a valve selectively sealing first and second openings thereof and a canopy biased toward a sealing position sealingly surrounding the first opening. The bias of the canopy is set to define a first pressure differential at which the canopy is moved out of the sealing position to permit fluid transfer therepast in a first direction. A duck-bill stem extends through the second opening and includes a lumen extending therethrough with walls of the stem being biased toward a sealing position and configured so that, when a second pressure differential is applied at at least a second level, the first end opens to permit flow therepast.

Abstract: A computerized system and method for automatically determining customized configurations for each of a plurality of endpoints of a virtual private network (VPN) and deploying the configurations to the endpoints, comprising: accepting, using an interface, parameters required for building the configurations from a user, the configurations enabling the endpoints to process a mixture of time sensitive and non-time sensitive data, and the parameters comprising: endpoint IP addressing scheme information and network design information; automatically generating, using at least one configuration engine, complete customized endpoint configurations for the parameters, and instantiating the configurations based on endpoint hardware-specific information, with no further input required from the user; and deploying, using a scheduler, the configurations to the endpoints of the at least one VPN, wherein the VPN is an mGRE VPN using NHRP protocol.

Abstract: A solution for use in medical procedures, comprises including a plurality of microspheres holding a fluorescent dye reactive to ultraviolet light and a base dye which, under white light, has one of a color substantially matching a color of a target portion of skin into which it is to be injected and which has, under UV light, a color slightly darker than a color of the target portion of skin. A method comprises identifying a target area of the skin to be accessed in a medical procedure and injecting into at least a portion of the target area a solution including a plurality of microspheres holding a colored dye and a fluorescent dye reactive to ultraviolet light in combination with locating the target area by illuminating the skin with ultraviolet light.

Abstract: An implantable port for accessing internal body structures, the port comprises a proximal housing including an opening providing access to an interior of the port and a distal housing adapted for assembly with the proximal housing, the distal housing including a reservoir which, when the distal housing is mated with the proximal housing is in fluid communication with the opening of the proximal housing in combination with a radiopaque element in one of the proximal and distal housings, a shape of the radiopaque element identifying, when imaged, a structural characteristic of the port not otherwise identifiable visually.

Abstract: The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.

Abstract: An implantable port comprises a port body forming a fluid reservoir and a septum sealing a proximal end of the reservoir in combination with a clicker member biased toward a first configuration, the clicker member being deformable via mechanical force applied thereto and configured so that, when subject to a force of at least a predetermined magnitude, the clicker member rapidly deforms away from the first configuration to a second configuration to provide one of an aural and tactile feedback to the user.

Abstract: The present invention generally relates to methods and compositions for expressing proteins or polypeptides in prokaryotic hosts using eukaryotic signal sequences.