Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.

Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.

Abstract: Compositions and methods of treating a subject for a coronavirus infection are provided. The methods typically include administering the subject an effective amount of probenecid, a metabolite or analog thereof, or a pharmaceutically acceptable salt thereof. The methods can by therapeutic and/or prophylactic. The amount of probenecid or a pharmaceutically acceptable salt thereof can be effective to, for example, reduce viral replication, reduce one or more symptoms of disease, disorder, or illness associated with virus, or a combination thereof. In preferred embodiments, the virus is a Severe acute respiratory syndrome-related coronavirus such as SARS-CoV-2 or SARS-CoV, a Middle East respiratory syndrome-related coronavirus such as MERS-CoV, or a coronavirus that causes the common cold.

Abstract: Implementations described herein include a hoisting device and method for handling, coupling and recovery of tubular members such as drill string components. The hoisting device has a self-energizing gripping means configured to releasably engage a drill string component. In one aspect, the self-energizing gripping means can be operable to increase at least one of a radial biasing force and a contact friction force applied to a drill string component, causing the gripping means to increase the overall gripping force applied to the component with minimal effort exerted by a hoisting device operator.

Abstract: Implementations described herein include a hoisting device and method for handling, coupling and recovery of tubular members such as drill string components. The hoisting device has a self-energizing gripping means configured to releasably engage a drill string component. In one aspect, the self-energizing gripping means can be operable to increase at least one of a radial biasing force and a contact friction force applied to a drill string component, causing the gripping means to increase the overall gripping force applied to the component with minimal effort exerted by a hoisting device operator.

Abstract: Implementations described herein include a hoisting device and method for handling, coupling and recovery of tubular members such as drill string components. The hoisting device has a self-energizing gripping means configured to releasably engage a drill string component. In one aspect, the self-energizing gripping means can be operable to increase at least one of a radial biasing force and a contact friction force applied to a drill string component, causing the gripping means to increase the overall gripping force applied to the component with minimal effort exerted by a hoisting device operator.

Abstract: A threaded drill string component having a hollow elongate body with a box end portion, an opposing pin end portion and a cylindrical mid-body portion that extends longitudinally between the respective box and pin end portions and has a variable wall diameter. The mid-body inner wall of the mid-body portion has at least one projecting portion or upset that is spaced from both the box and pin end portions and extends inwardly toward a central longitudinal axis of the hollow body and a plurality of troughs defined in the mid-body inner wall of the mid-body portion.

Abstract: Fluid control assemblies including at least one ring. The fluid control assemblies are used within core barrel assemblies to: provide an indication that a core barrel assembly has reached a drilling position and is latched to a drill string; serve as a mechanical shut-off valve that restricts the flow of drilling fluid within a core barrel assembly; and/or serve as a grease seal at the connection between an inner tube cap and an inner tube that receives a core sample.

Abstract: Drill bits having flushing channels and surface features that cooperate to evacuate cuttings. The surface features can be provided as flutes, fins, and/or ribs defined in a body portion of the bits. Optionally, the surface features can define back-cutting edges the permit back reaming.

Abstract: A threaded drill string component having a hollow elongate body with a box end portion, an opposing pin end portion and a cylindrical mid-body portion that extends longitudinally between the respective box and pin end portions and has a variable wall diameter. The mid-body inner wall of the mid-body portion has at least one projecting portion or upset that is spaced from both the box and pin end portions and extends inwardly toward a central longitudinal axis of the hollow body and a plurality of troughs defined in the mid-body inner wall of the mid-body portion.

Abstract: Threaded drill string component having a hollow elongate body with a box end portion, an opposing pin end portion and a cylindrical mid-body portion that extends longitudinally between the respective box and pin end portions and has a variable wall diameter. The mid-body inner wall of the mid-body portion has at least one projecting portion or upset that is spaced from both the box and pin end portions and extends inwardly toward a central longitudinal axis of the hollow body and a plurality of troughs defined in the mid-body inner wall of the mid-body portion.

Abstract: Implementations described herein include a hoisting device and method for handling, coupling and recovery of tubular members such as drill string components. The hoisting device has a self-energizing gripping means configued to releasably engage a drill string component. In one aspect, the self-energizing gripping means can be operable to increase at least one of a radial biasing force and a contact friction force applied to a drill string component, causing the gripping means to increase the overall gripping force applied to the component with minimal effort exerted by a hoisting device operator.

Abstract: Implementations described herein include a hoisting device and method for handling, coupling and recovery of tubular members such as drill string components. The hoisting device has a self-energizing gripping means configured to releasably engage a drill string component. In one aspect, the self-energizing gripping means can be operable to increase at least one of a radial biasing force and a contact friction force applied to a drill string component, causing the gripping means to increase the overall gripping force applied to the component with minimal effort exerted by a hoisting device operator.

Abstract: Implementations described herein include a hoisting device and method for handling, coupling and recovery of tubular members such as drill string components. The hoisting device has a self-energizing gripping means configured to releasably engage a drill string component. In one aspect, the self-energizing gripping means can be operable to increase at least one of a radial biasing force and a contact friction force applied to a drill string component, causing the gripping means to increase the overall gripping force applied to the component with minimal effort exerted by a hoisting device operator.

Abstract: Drill bits having flushing channels and surface features that cooperate to evacuate cuttings. The surface features can be provided as flutes, fins, and/or ribs defined in a body portion of the bits. Optionally, the surface features can define back-cutting edges the permit back reaming.