Abstract: Provided herein are methods to synthesize compounds useful in the treatment of cancer where such compounds comprise a quinazolinyl core moiety and at least one stereoisomeric or atropisomeric moiety.

Abstract: A gas turbine engine comprises an electronic control unit adapted to control functions of the gas turbine engine and having a DC power input unit coupled to receive DC supply power and an ignition igniter coupled thereto. The ignition exciter includes an AC power input unit adapted to receive AC power from an AC power source within the gas turbine engine, a power rectification unit coupled to receive the AC power from the AC power source and configured, upon receipt thereof, to rectify the AC power into DC power, and a DC power output unit coupled to receive the DC power from the power rectification unit and configured to supply the DC power to the DC power input unit of the electronic control unit as DC supply power and/or the ignition igniter.

Abstract: An energy generation system for generating energy to be supplied to a chip zapping unit of for example a gas turbine engine comprises an ignition system, e.g. that of the gas turbine engine, the ignition system having an energy output and configured to supply operational energy to the energy output, and the chip zapping unit having an energy input, the energy input coupled to the energy output of the ignition system to receive the operational energy therefrom. Such an energy generation system generates the operational energy needed for the chip zapping unit directly from the ignition system thus avoiding pulse generation circuitry inside an electronic control unit.

Abstract: A gas turbine engine comprises an electronic control unit adapted to control functions of the gas turbine engine and having a DC power input unit coupled to receive DC supply power and an ignition igniter coupled thereto. The ignition exciter includes an AC power input unit adapted to receive AC power from an AC power source within the gas turbine engine, a power rectification unit coupled to receive the AC power from the AC power source and configured, upon receipt thereof, to rectify the AC power into DC power, and a DC power output unit coupled to receive the DC power from the power rectification unit and configured to supply the DC power to the DC power input unit of the electronic control unit as DC supply power and/or the ignition igniter.

Abstract: An energy generation system for generating energy to be supplied to a chip zapping unit of for example a gas turbine engine comprises an ignition system, e.g. that of the gas turbine engine, the ignition system having an energy output and configured to supply operational energy to the energy output, and the chip zapping unit having an energy input, the energy input coupled to the energy output of the ignition system to receive the operational energy therefrom. Such an energy generation system generates the operational energy needed for the chip zapping unit directly from the ignition system thus avoiding pulse generation circuitry inside an electronic control unit.

Abstract: A system for detecting imminent failure of rotatable equipment that has lost centerline control and is near catastrophic failure is housed in a linear tubular element within which is permanently potted a thin gage insulated wire protected by an optional fuse. The contact end of the wire is located immediately adjacent to a semiconductor disk and an optional abradable disk placed at close proximity to the rotatable equipment being monitored. The thin gage insulated wire return is connected between the fuse and the semiconductor disk providing an electrical return path for detection of a change in electrical continuity. The semiconductor and abradable disks between the contact wire and the rotatable equipment act as insulators from errant grounding. Loss of rotatable equipment centerline control will cause physical contact between the contact wire and rotatable equipment, breaking electrical continuity, the resulting ground path being instantly detected through the internally potted fuse.

Abstract: A system for detecting imminent failure of rotatable equipment that has lost centerline control and is near catastrophic failure is housed in a linear tubular element within which is permanently potted a thin gage insulated wire protected by an optional fuse. The contact end of the wire is located immediately adjacent to a semiconductor disk and an optional abradable disk placed at close proximity to the rotatable equipment being monitored. The thin gage insulated wire return is connected between the fuse and the semiconductor disk providing an electrical return path for detection of a change in electrical continuity. The semiconductor and abradable disks between the contact wire and the rotatable equipment act as insulators from errant grounding. Loss of rotatable equipment centerline control will cause physical contact between the contact wire and rotatable equipment, breaking electrical continuity, the resulting ground path being instantly detected through the internally potted fuse.