Patents by Inventor Jeff Ranish

Jeff Ranish has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CROSSLINKERS FOR MASS SPECTROMETRIC IDENTIFICATION AND QUANTITATION OF PEPTIDES
    Publication number: 20190084929
    Abstract: Crosslinking molecules that permit efficient identification of specifically associated proteins and the sites of crosslinking in biological or other samples include two cleavable bonds that are cleavable under the same conditions as peptide bonds in mass spectrometric determinations. Sets of the invention crosslinkers may be provided with isobaric labels containing reporter ions of differing molecular weights to permit relative quantitation of crosslinked protein pairs.
    Type: Application
    Filed: March 10, 2017
    Publication date: March 21, 2019
    Applicant: Institute for Systems Biology
    Inventors: Jie LUO, Jeff RANISH
  • Method to determine protein interaction sites
    Patent number: 8535948
    Abstract: The invention provides improved crosslinkers which permit more efficient determination of protein interactions in biological samples.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: September 17, 2013
    Assignee: Institute for Systems Biology
    Inventors: Jeff Ranish, Jie Luo
  • Mass spectrum-based identification and quantitation of proteins and peptides
    Patent number: 8227251
    Abstract: The present invention relates to methods for analyzing complex mixtures of proteins, both for identification and quantitation of proteins of interest, and in particular, methods of identification and quantitation of proteins present at low levels, using internal standard peptides isobarically tagged at the N and C termini.
    Type: Grant
    Filed: April 14, 2010
    Date of Patent: July 24, 2012
    Assignee: Institute for Systems Biology
    Inventors: Jeff Ranish, Jie Luo, Wei Yan
  • MASS SPECTRUM-BASED IDENTIFICATION AND QUANTITATION OF PROTEINS AND PEPTIDES
    Publication number: 20100261279
    Abstract: Method to quantitate peptides in a sample by mass spectroscopy wherein the improvement comprises providing internal standard peptides isobarically tagged at the N and C terminus.
    Type: Application
    Filed: April 14, 2010
    Publication date: October 14, 2010
    Inventors: Jeff RANISH, Jie Luo, Wei Yan
  • METHOD TO DETERMINE PROTEIN INTERACTION SITES
    Publication number: 20100248261
    Abstract: The invention provides improved crosslinkers which permit more efficient determination of protein interactions in biological samples.
    Type: Application
    Filed: March 26, 2010
    Publication date: September 30, 2010
    Inventors: Jeff RANISH, Jie Luo