Patents by Inventor Jeff Shimizu
Jeff Shimizu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210396985Abstract: A lens system comprises a first lens group and a second lens group, and is configured to form an image at a first magnification and at a second magnification. The lens system has a common optical axis in both magnifications. The lens system is further configured to form an intermediate image between the first lens group and the second lens group at the first magnification. The intermediate image formed in the first magnification is further imaged onto an optical detector. In the first magnification, the second lens group acts as a relay lens imaging the intermediate image onto the optical detector. In the second magnification, the first and second lens groups together form an image on the optical detector without forming an intermediate image.Type: ApplicationFiled: August 31, 2021Publication date: December 23, 2021Inventors: Bernardus Hendrikus Wilhelmus HENDRIKS, Jeff SHIMIZU, Stein KUIPER
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Patent number: 11119305Abstract: A lens system comprises a first lens group and a second lens group, and is configured to form an image at a first magnification and at a second magnification. The lens system has a common optical axis in both magnifications. The lens system is further configured to form an intermediate image between the first lens group and the second lens group at the first magnification. The intermediate image formed in the first magnification is further imaged onto an optical detector. In the first magnification, the second lens group acts as a relay lens imaging the intermediate image onto the optical detector. In the second magnification, the first and second lens groups together form an image on the optical detector without forming an intermediate image.Type: GrantFiled: January 22, 2018Date of Patent: September 14, 2021Assignee: KONINKLIJKE PHILIPS N.V.Inventors: Bernardus Hendrikus Wilhelmus Hendriks, Jeff Shimizu, Stein Kuiper
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Publication number: 20180318496Abstract: A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).Type: ApplicationFiled: July 13, 2018Publication date: November 8, 2018Applicant: Progenity, Inc.Inventors: Hans Zou, Jeff Shimizu, Johan Frederik Dijksman
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Publication number: 20180296814Abstract: The invention relates to a method and an electronic pill (20) for administration of at least one drug (3) to a patient, wherein a delivery profile of the at least one drug is determined according to at least one individual parameter of the patient. The at least one individual parameter may particularly relate to a genotype (GEN) or phenotype of the patient and for example comprise a distribution of proteins in the patient's gastrointestinal tract (GIT). Optionally, the individual parameter may be adjusted based on measurements by the electronic pill or external devices during its passage through the patient's gastrointestinal tract.Type: ApplicationFiled: June 1, 2018Publication date: October 18, 2018Applicant: Progenity, Inc.Inventor: Jeff Shimizu
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Patent number: 10046109Abstract: A drug delivery device (50) is provided comprising a drug reservoir (10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug de delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).Type: GrantFiled: August 10, 2010Date of Patent: August 14, 2018Assignee: Progenity, Inc.Inventors: Hans Zou, Jeff Shimizu, Johan Frederik Dijksman
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Publication number: 20180200426Abstract: A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.Type: ApplicationFiled: January 25, 2018Publication date: July 19, 2018Inventors: JOHAN FREDERIK DIJKSMAN, FRITS TOBI DE JONGH, MICHEL GERARDUS PARDOEL, ANKE PIERIK, JUDITH MARGREET RENSEN, JEFF SHIMIZU, HANS ZOU, REMUS ALBU, VENTZESLAV IORDANOV, HANS MARC BERT BOEVE
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Publication number: 20180143422Abstract: A lens system comprises a first lens group and a second lens group, and is configured to form an image at a first magnification and at a second magnification. The lens system has a common optical axis in both magnifications. The lens system is further configured to form an intermediate image between the first lens group and the second lens group at the first magnification. The intermediate image formed in the first magnification is further imaged onto an optical detector. In the first magnification, the second lens group acts as a relay lens imaging the intermediate image onto the optical detector. In the second magnification, the first and second lens groups together form an image on the optical detector without forming an intermediate image.Type: ApplicationFiled: January 22, 2018Publication date: May 24, 2018Inventors: Bernardus Hendrikus Wilhelmus HENDRIKS, Jeff SHIMIZU, Stein KUIPER
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Patent number: 9878094Abstract: A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.Type: GrantFiled: November 6, 2007Date of Patent: January 30, 2018Assignee: STOCO 10 GMBHInventors: Johan Frederik Dijksman, Frits Tobi De Jongh, Michel Gerardus Pardoel, Anke Pierik, Judith Margreet Rensen, Jeff Shimizu, Hans Zou, Remus Albu, Ventzeslav Iordanov, Hans Marc Bert Boeve
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Patent number: 9744139Abstract: An ingestible capsule (10) is provided for delivery of a drug, the capsule (10) comprises a first module (11) and a second module (12). The first module (11) has at least one drug compartment (13) for comprising an amount of the drug. The drug compartment (13) is sealed by a foil (14) with an embedded conducting heating wire (15). The second (12) module comprises electronics (18) for providing an electrical pulse to the heating wire (15) in order to open the drug compartment (13) by melting the foil (14). The first module (11) and second module (12) comprise interoperable connection means (19) for securing the first module (11) to the second module (12) such that the heating wire (15) is electronically coupled to the electronics (18).Type: GrantFiled: April 2, 2010Date of Patent: August 29, 2017Assignee: Stoco 10 GmbHInventors: Johan Frederik Dijksman, Anke Pierik, Frits Tobi De Jongh, Jeff Shimizu, Hans Zou, Lucian Remus Albu, Olaf Weiner
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Patent number: 9687638Abstract: The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit hole 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.Type: GrantFiled: March 23, 2012Date of Patent: June 27, 2017Assignee: Medimetrics Personalized Drug DeliveryInventors: Hans Zou, Jeff Shimizu
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Patent number: 9616206Abstract: The invention relates to an electronic pill (102) for delivery of a medication (104) inside a mammal. The electronic pill (102) comprises a reservoir (106) for releasing the medication (104) in response to a predefined level of pressure. Furthermore a primary elastic element (108) is comprised for applying said predefined level of pressure to the reservoir (106) via a piston (110) upon release from the piston (110) of its constrained position. The piston (110) in its turn, when in constrained position, induces a predefined level of stress in the primary elastic element (108) by accordingly deforming it. The electronic pill (102) comprises a mechanism (114) for changing, upon actuation, from a constraining configuration in which the piston (110) is maintained at its constrained position to a releasing configuration in which the piston (110) is released.Type: GrantFiled: September 29, 2011Date of Patent: April 11, 2017Assignee: Medimetrics Personalized Drug DeliveryInventors: Michel Gerardus Pardoel, Hans Zou, Jeff Shimizu
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Patent number: 9550050Abstract: An electronic capsule (100) is provided. The capsule (100) has a discrete drive element (300) comprising: a housing (109), electronics for making the electronic capsule (100) operable, a pumping mechanism (115) for dosing and displacing a substance, a power source (105) for powering the electronic capsule (100) and enabling the electronics and the pumping mechanism (115) to operate, and a locking mechanism (130); and a discrete payload element (200) comprising: a housing (109), a reservoir (210) for storing the substance, one or more openings (250) in the housing (109) for releasing the substance from the reservoir (210) and a locking mechanism (230) for engaging the drive element locking mechanism (130). Engagement of the drive element locking mechanism (130) with the payload element locking mechanism (230) secures the drive element (300) to the payload element (200), thereby making the electronic capsule (100) operable and specific.Type: GrantFiled: September 20, 2007Date of Patent: January 24, 2017Assignee: Medimetrics Personalized Drug Delivery B.V.Inventors: Johan Frederik Dijksman, Anke Pierik, Judith Margreet Rensen, Jeff Shimizu, Hans Zou, Michel Pardoel, Frits Tobi De Jongh
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Patent number: 9417104Abstract: Gastrointestinal screening includes disposing a self-contained electronic capsule in a gastrointestinal tract. The electronic capsule is adapted to acquire data that is responsive to one or more physical conditions in the gastrointestinal tract and to compare the acquired data with stored threshold data to generate a discrete output relating to the condition of the gastrointestinal tract.Type: GrantFiled: December 5, 2006Date of Patent: August 16, 2016Assignee: Medimetrics Personalized Drug Delivery B.V.Inventors: Jeff Shimizu, Karen Trovato
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Patent number: 9227011Abstract: A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.Type: GrantFiled: September 27, 2007Date of Patent: January 5, 2016Assignee: Medimetrics Personalized Drug Delivery B.V.Inventors: Jeff Shimizu, Hans Zou, Johan Frederik Dijksman, Anke Pierik, Judith Margaret Rensen
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Patent number: 9067011Abstract: A device for placement in an environment, particularly a humid environment, for delivery of medication to said environment. The device comprises a reservoir (103) having an orifice (104), a conveying unit for conveying a reservoir's content (106) through the orifice (104) and an actuator arrangement for driving the conveying unit. In order to provide a reliable delivery of medication in a humid environment, the conveying unit comprises an auger (110) extending in the reservoir (103).Type: GrantFiled: June 17, 2009Date of Patent: June 30, 2015Assignee: Medimetrics Personalized Drug Delivery B.V.Inventors: Hans Zou, Jeff Shimizu, Lucian R. Albu, Johan F. Dijksman
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Publication number: 20150141967Abstract: The invention relates to an electronic pill (102) for delivery of a medication (104) inside a mammal. The electronic pill (102) comprises a reservoir (106) for releasing the medication (104) in response to a predefined level of pressure. Furthermore a primary elastic element (108) is comprised for applying said predefined level of pressure to the reservoir (106) via a piston (110) upon release from the piston (110) of its constrained position. The piston (110) in its turn, when in constrained position, induces a predefined level of stress in the primary elastic element (108) by accordingly deforming it. The electronic pill (102) comprises a mechanism (114) for changing, upon actuation, from a constraining configuration in which the piston (110) is maintained at its constrained position to a releasing configuration in which the piston (110) is released.Type: ApplicationFiled: September 29, 2011Publication date: May 21, 2015Applicant: Medimetrics Personalized Drug DeliveryInventors: Michel Gerardus Pardoel, Hans Zou, Jeff Shimizu
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Patent number: 8990018Abstract: A kit includes a swallowable capsule (1, 45) with a potentiometric sensor (3), such as a pH sensor, with an unfilled electrolyte cell (31). The kit further includes a separate container (46) containing a liquid electrolyte. The kit can, e.g., be packed in a blister package. After unpacking the capsule the electrolyte cell (31) is filled with the electrolyte.Type: GrantFiled: March 24, 2009Date of Patent: March 24, 2015Assignee: Medimetrics Personalized Drug Delivery B.V.Inventors: Johan Frederik Dijksman, Anke Pierik, Judith Margreet Rensen, Jeff Shimizu, Petrus Leonardus Adrianus Van Der Made, Michel Gerardus Pardoel, Frits Tobi De Jongh, Johan Gerard Kleibeuker
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Patent number: 8961498Abstract: Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.Type: GrantFiled: June 18, 2009Date of Patent: February 24, 2015Assignee: Medimetrics Personalized Drug DeliveryInventors: Hans Zou, Jeff Shimizu, Lucian R. Albu, Johan F. Dijksman
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Patent number: 8911425Abstract: Electronic pill (1, 11) comprising at least one medicine reservoir (2, 12) with a solid powder or granulate medicine, a discharge opening (3, 13) and an actuator responsive to control circuitry for displacing medicine from the reservoir (2, 12) to the discharge opening (3, 13). The medicine comprises a dispersion of one or more active ingredients—e.g., solids in powder or granulate form—in an inert carrier matrix. Optionally, the active ingredients are dispersed using intestinal moisture absorbed into the pill via a semi-permeable wall section (14).Type: GrantFiled: July 3, 2009Date of Patent: December 16, 2014Assignee: Medimetrics Personalized Drug DeliveryInventors: Johan Frederik Dijksman, Anke Pierik, Jeff Shimizu, Hans Zou
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Patent number: 8852155Abstract: A medicine reservoir (10) is provided for use with a drug delivery device (50). The medicine reservoir (10) is arranged for comprising a drug (13) and comprises a dispensing hole (15) for dispensing the drug (13) into an environment of the drug delivery device (50). The medicine reservoir (10) further comprises a deformable plug (14) which plug (14) is removable by pressure caused by a dispensing action of the drug delivery device (50).Type: GrantFiled: August 9, 2010Date of Patent: October 7, 2014Assignee: Medimetrics Personalized Drug DeliveryInventors: Hans Zou, Jeff Shimizu, Lucian Remus Albu