Patent number: 12163952
Abstract: Provided herein are methods, compositions and articles of manufacture for use in connection with cell therapy involving the administration of one or more doses of a therapeutic T cell composition. The cells of the T cell composition express recombinant receptors such as chimeric receptors, e.g. chimeric antigen receptors (CARs) or other transgenic receptors such as T cell receptors (TCRs). Features of the provided embodiments, including the numbers of cells or units of cells administered and/or the potency of administered cells, provide various advantages, such as lower risk of toxicity in subjects administered the T cell compositions.
Type:
Grant
Filed:
February 27, 2018
Date of Patent:
December 10, 2024
Assignee:
Juno Therapeutics, Inc.
Inventors:
Brian Christin, Michael Gerard Covington, Kedar Himanshu Dave, Richard James Getto, Jr., Tom Kowski, Ryan P. Larson, Christopher Glen Ramsborg, Nikolaus Sebastian Trede, Clinton Weber, James Boyd Whitmore, Nathan Yee, Pascal Beauchesne, Travis Beckett, Samuel Charles Blackman, Nathaniel Chartrand, Mel Davis-Pickett, Mark Gilbert, Nathaniel Lambert, He Li, Mary Mallaney, Kathryn Lindsay Pollock, Valerie Odegard, Jeff Smith, Claire Sutherland, Andrew W. Walker
Publication number: 20240379033
Abstract: Methods, apparatus, devices, subsystems, and systems for holographically displaying three-dimensional objects are provided. In one aspect, an optical device includes: an optical guiding device configured to guide light to propagate along a first direction within the optical guiding device, the light including multiple colors of light; an in-coupling diffractive structure configured to diffract the light to propagate in the optical guiding device; and a plurality of out-coupling diffractive structures arranged downstream of the in-coupling diffractive structure along the first direction and configured to diffract at least part of the light out of the optical guiding device along a second direction different from the first direction. The optical device can be configured for at least one of: color crosstalk suppression among the multiple colors of light, display zero order light suppression, dispersion compensation, or ambient light blocking.
Type:
Application
Filed:
May 10, 2024
Publication date:
November 14, 2024
Inventors:
Jonathan Seamus BLACKLEY, Richard BAHR, Watson Brent BOYETT, Sylvain Marcel COLIN, Robin James GREEN, Isaac Serrano GUASCH, Stephen John HART, Robert Alan HESS, Margaret H. HSU, Christoph Von JUTRZENKA, DeaGyu KIM, Mark Anthony LOYA, Kelly Swan MACNEILL, Benjamin Francis NEIL, Kamran QADERI, Tina QIN, Jesus Manuel Caridad RAMIREZ, Jayakrishna SASHIDHARAN, Asher Zelig SEFAMI, Jeff SMITH, Robert David SRINIVASIAH, Sameer Sudhir WALAVALKAR, Joshua D. WIENSCH, Daniel Dereck WILLIAMSON