Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.

Abstract: Implant inserters and related methods are disclosed herein, e.g., for delivering a fusion cage or other implant to a spinal disc space and for rotating or articulating the implant within the disc space. An exemplary instrument can include an inner member having opposed jaws for grasping the implant and holding the implant during insertion. The inner member can be slidably received within an outer member such that relative axial translation of the inner and outer members is effective to open or close the jaws. The jaws and/or the distal end of the outer member can have a low-profile geometry, which can advantageously facilitate certain surgical procedures. For example, the low-profile geometry can allow for a more medial approach to an intervertebral disc space in which the implant is to be inserted.

Abstract: Disclosed herein are systems for routing wireless communications. Some systems may include an apparatus comprising an enclosure configured to attach to an external portion of an aircraft and which may contain: a wireless communications device, and an antenna in communication with the wireless communications device and configured to send or receive signals to and/or from aircraft.

Abstract: Implant inserters and related methods are disclosed herein, e.g., for delivering a fusion cage or other implant to a spinal disc space and for rotating or articulating the implant within the disc space. An exemplary instrument can include an inner member having opposed jaws for grasping the implant and holding the implant during insertion. The inner member can be slidably received within an outer member such that relative axial translation of the inner and outer members is effective to open or close the jaws. The jaws and/or the distal end of the outer member can have a low-profile geometry, which can advantageously facilitate certain surgical procedures. For example, the low-profile geometry can allow for a more medial approach to an intervertebral disc space in which the implant is to be inserted.

Abstract: Disclosed herein are systems for routing wireless communications. Some systems may include an apparatus comprising an enclosure configured to attach to an external portion of an aircraft and which may contain: a wireless communications device, and an antenna in communication with the wireless communications device and configured to send or receive signals to and/or from aircraft.

Abstract: Implant inserters and related methods are disclosed herein, e.g., for delivering a fusion cage or other implant to a spinal disc space and for rotating or articulating the implant within the disc space. An exemplary instrument can include an inner member having opposed jaws for grasping the implant and holding the implant during insertion. The inner member can be slidably received within an outer member such that relative axial translation of the inner and outer members is effective to open or close the jaws. The jaws and/or the distal end of the outer member can have a low-profile geometry, which can advantageously facilitate certain surgical procedures. For example, the low-profile geometry can allow for a more medial approach to an intervertebral disc space in which the implant is to be inserted.

Abstract: Disclosed herein are systems for routing wireless communications. Some systems may include an apparatus comprising an enclosure configured to attach to an external portion of an aircraft and which may contain: a wireless communications device, and an antenna in communication with the wireless communications device and configured to send or receive signals to and/or from aircraft.

Abstract: Disclosed herein are systems for routing wireless communications. Some systems may include an apparatus comprising an enclosure configured to attach to an external portion of an aircraft and which may contain: a wireless communications device, and an antenna in communication with the wireless communications device and configured to send or receive signals to and/or from aircraft.

Abstract: Implant inserters and related methods are disclosed herein, e.g., for delivering a fusion cage or other implant to a spinal disc space and for rotating or articulating the implant within the disc space. An exemplary instrument can include an inner member having opposed jaws for grasping the implant and holding the implant during insertion. The inner member can be slidably received within an outer member such that relative axial translation of the inner and outer members is effective to open or close the jaws. The jaws and/or the distal end of the outer member can have a low-profile geometry, which can advantageously facilitate certain surgical procedures. For example, the low-profile geometry can allow for a more medial approach to an intervertebral disc space in which the implant is to be inserted.

Abstract: Example implementations may relate to an obstacle detection system. In particular, an example device may include a light emitter, a line-image sensor, and a controller that are mounted on a rotatable component. In an example embodiment, the line-image sensor may receive light signals emitted from the light emitter. The controller may be communicatively coupled to the light emitter and line-image sensor and configured to determine a multipath signal based on the time of flight of the light signal and the position along the line-image sensor at which the line-image sensor received the given reflected light signal.

Abstract: The present invention relates to an improved steering wheel rotating apparatus that utilizes magnetic forces to permit an individual with reduced strength and/or functioning of his/her arms to more easily control the steering of an automobile.

Abstract: A magnetic reduced effort braking apparatus for use to reduce the amount of effort required to depress the brake pedal of a vehicle. A rigid plate is secured to the floor of a vehicle between the gas pedal and the brake pedal and adjacent to the brake pedal and a first magnet is secured to the rigid plate. A second magnet is secured to the underside of the brake pedal slightly aligned with but slightly offset from the location of the first magnet. The magnets attract one another and reduce the amount of foot pressure required to depress the brake pedal.

Abstract: A rudder and dynamic trim adjusting apparatus for a boat includes a rudder, a rudder shaft extending from the rudder and being rotatable about a longitudinal axis thereof to rotate the rudder, trim fins extending from the rudder, along at least one transverse axis transverse to the longitudinal axis, and a mechanism connected to the trim fins, and being operable, independently of rotation of the rudder shaft to rotate the trim fins about the at least one transverse axis. Methods of controlling an attitude of a boat hull are provided.

Abstract: A window blind assembly includes a headrail having a longitudinal axis, a bottom rail suspended below the headrail and a window covering material extending between the headrail and the bottom rail, the window covering material having an upper end attached to the headrail and a lower end attached to the bottom rail. The assembly also includes a traversable tube disposed in the headrail, the traversable tube having first and second ends. The assembly includes a threaded support rod secured to the headrail adjacent a first end of the tube, the threaded support rod being threadably coupled with the first end of the tube for providing traversing motion to the tube. The assembly also includes a spring motor secured to said headrail adjacent a second end of the tube.

Abstract: A rudder and dynamic trim adjusting apparatus for a boat includes a rudder, a rudder shaft extending from the rudder and being rotatable about a longitudinal axis thereof to rotate the rudder, trim fins extending from the rudder, along at least one transverse axis transverse to the longitudinal axis, and a mechanism connected to the trim fins, and being operable, independently of rotation of the rudder shaft to rotate the trim fins about the at least one transverse axis. Methods of controlling an attitude of a boat hull are provided.

Abstract: A window blind assembly includes a headrail having a longitudinal axis extending between first and second ends thereof, a first tube rotatably mounted between the first and second ends of the headrail and a second tube rotatably mounted between the first tube and the second end of the headrail. The assembly also has a bottom rail suspended below the headrail, an intermediate rail suspended below the headrail and positioned between the headrail and the bottom rail, and a window covering material extending between the intermediate rail and the headrail, the window covering material having an upper end attached to the intermediate rail and a lower end attached to the bottom rail.

Abstract: A window blind assembly includes a headrail having a longitudinal axis extending between first and second ends thereof, a first tube rotatably mounted between the first and second ends of the headrail and a second tube rotatably mounted between the first tube and the second end of the headrail. The assembly also has a bottom rail suspended below the headrail, an intermediate rail suspended below the headrail and positioned between the headrail and the bottom rail, and a window covering material extending between the intermediate rail and the headrail, the window covering material having an upper end attached to the intermediate rail and a lower end attached to the bottom rail.