Abstract: The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting or blocking NUAK kinase, such as cancers and fibrosis.

Abstract: The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting or blocking NUAK kinase, such as cancers and fibrosis.

Abstract: A system and method for inserting an implant into soft tissue. The system may include an elongate arm having an implant at a first end of the elongate arm and an actuator at a second end of the elongate arm. The implants may be contained in a cartridge assembly. Methods of inserting an implant may be used during nasal septum reconstruction.

Abstract: A system and method for inserting an implant into soft tissue. The system may include an elongate arm having an implant at a first end of the elongate arm and an actuator at a second end of the elongate arm. The implants may be contained in a cartridge assembly. Methods of inserting an implant may be used during nasal septum reconstruction.

Abstract: A system and method for inserting an implant into soft tissue. The system may include an elongate arm having an implant at a first end of the elongate arm and an actuator at a second end of the elongate arm. The implants may be contained in a cartridge assembly. Methods of inserting an implant may be used during nasal septum reconstruction.

Abstract: Methods for classifying samples are based on alterations in network modularity. The methods are useful for the diagnosis, prognosis and monitoring of a biological state such as a disease state. In certain embodiments, methods for diagnosing disease or evaluating the prognosis of disease or identification of a disease state are computer-implemented.

Abstract: Methods for classifying samples are based on alterations in network modularity. The methods are useful for the diagnosis, prognosis and monitoring of a biological state such as a disease state. In certain embodiments, methods for diagnosing disease or evaluating the prognosis of disease or identification of a disease state are computer-implemented.

Abstract: A system and method for inserting an implant into soft tissue. The system may include an elongate arm having an implant at a first end of the elongate arm and an actuator at a second end of the elongate arm. The implants may be contained in a cartridge assembly. Methods of inserting an implant may be used during nasal septum reconstruction.

Abstract: The invention relates to methods and reagents for screening, identifying, and/or quantifying molecular interactions. In particular, the invention provides a method for identifying protein-protein interactions comprising prey proteins interacting with bait proteins comprising: (a) introducing one or more prey protein in cells, wherein a prey protein is labelled with an epitope tag permitting separation of the prey protein from other proteins in the cells; (b) introducing one or more bait protein in the cells, wherein a bait protein is labelled with a detectable substance permitting detection of protein-protein interactions comprising a prey protein and the bait protein; and (c) assaying for protein-protein interactions comprising a prey protein and bait protein by detecting the detectable substance.