Abstract: Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.

Abstract: An autonomous vehicle includes one or more sensors for detecting an object in an environment surrounding the autonomous vehicle and a vehicle computing system comprising one or more processors receiving canonical route data associated with at least one canonical route, and controlling travel of the autonomous vehicle based on sensor data from the one or more sensors and the canonical route data associated with the at least one canonical route. The at least one canonical route comprises at least one roadway connected with another roadway in a plurality of roadways in a geographic location that satisfies at least one route optimization function derived based on trip data associated with one or more traversals of the plurality of roadways in a geographic location by one or more autonomous vehicles.

Abstract: The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 ?g/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.

Abstract: A nanocrystalline magnetic conductive sheet for wireless charging and a preparation method therefor are provided. The nanocrystalline magnetic conductive sheet includes a composition of Fe(100-x-y-z-?-?-?)MxCuyM?zSi?B?X?, saturation magnetic induction is greater than or equal to 1.25T. The preparation method includes preparing an alloy with a preset composition of into an alloy strip with an initial state of amorphousness by a single roll rapid quenching method, annealing an amorphous alloy strip according to a preset annealing process, to obtain a nanocrystalline strip, performing a magnetic fragmentation process on the nanocrystalline strip, to obtain the nanocrystalline magnetic conductive sheet for wireless charging.

Abstract: A lock device for locking the sliding door comprises a first lock portion and a transmission portion. The transmission portion may move along relative to the first lock portion a predetermined path, so that the transmission portion may bring the sliding door to move along the predetermined path to open or close the sliding door. The transmission portion has a plurality of successively arranged mating portions for locking with the first lock portion. The first lock portion has a first position in which the first lock portion is locked with the transmission portion and a second position in which the first lock portion is released from the transmission portion. The transmission portion may be locked in different positions along the predetermined path by matching the first lock portion 110 with different mating portions, so that the sliding door can be locked in different positions.

Abstract: The invention disclosed herein relates to aza-quinoline compounds of Formula (I), pharmaceutical compositions comprising such compounds, and the use of such compounds for treating a disease or condition mediated by Enhancer of Zeste Homolog 2 (EZH2), Polycomb Repressive Complex 2 (PRC2), or a combination thereof.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: A nanocrystalline magnetic conductive sheet for wireless charging and a preparation method therefor are provided. The nanocrystalline magnetic conductive sheet includes a composition of Fe(100-x-y-z-?-?-?)MxCuyM?zSi?B?X?, saturation magnetic induction is greater than or equal to 1.25 T. The preparation method includes preparing an alloy with a preset composition of into an alloy strip with an initial state of amorphousness by a single roll rapid quenching method, annealing an amorphous alloy strip according to a preset annealing process, to obtain a nanocrystalline strip, performing a magnetic fragmentation process on the nanocrystalline strip, to obtain the nanocrystalline magnetic conductive sheet for wireless charging.

Abstract: Provided aza-quinoline compounds of Formula (I), pharmaceutical compositions comprising such compounds; and the use of such compounds for treating a disease or condition mediate by Enhancer of Zeste Homolog 2 (EZH2), Polycomb Repressive Complex 2 (PRC2), or a combination thereof.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: The present disclosure relates to the technical field of lock, especially to the lock device for locking the sliding door. The lock device comprises a first lock portion and a transmission portion. The transmission portion may move along relative to the first lock portion a predetermined path, so that the transmission portion may bring the sliding door to move along the predetermined path to open or close the sliding door. The transmission portion has a plurality of successively arranged mating portions for locking with the first lock portion. The first lock portion has a first position in which the first lock portion is locked with the transmission portion and a second position in which the first lock portion is released from the transmission portion. The transmission portion may be locked in different positions along the predetermined path by matching the first lock portion (110) with different mating portions, so that the sliding door can be locked in different positions.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: Contemplated gas-liquid separators and especially subsea gas-liquid separators have a main pipe with a plurality of descending branch pipes that are fluidly coupled to the main pipe and each other such as to allow disengagement of the gas into the main pipe while liquid and sand descend into the lower ends of the branch pipes. Sand accumulation in the lower ends of the branch pipes is preferably prevented by lateral serial flow of liquid and sand from one branch pipe to the next and use of a flush liquid that is drawn from one or more branch pipes.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: A compound of Formula (I), or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for treating a PRC2-mediated disease or disorder: wherein R1, R2, R3, R4, R5, and n are as defined herein.

Abstract: A computer-implemented method that includes the actions of receiving a request for data indicative of topics of interest for a user segment of a social networking platform, accessing user data for one or more users of the social networking platform, comparing the one or more user characteristics that are associated with the user segment to user characteristics associated with the accessed user data, identifying, based on comparing, a portion of the accessed user data that pertains to the user segment, analyzing contents of the portion of the accessed user data that pertains to the user segment, determining, based on analyzing, one or more elements in the portion of the accessed user data that pertain to a topic of interest for the user segment, and transmitting, to a client device that sent the request, data indicative of elements pertaining to the topics of interest for the user segment.

Abstract: Data associated with a plurality of check-ins performed by users of a social network is received by processors where each check-in identifies a location and tags associated with the location within the social network that are used by the social network to describe the location. A mapping of tags to categories from a list of categories where each tag is mapped to a single category is accessed by the processors. One or more categories are determined by the processors for each check-in based on the mapping of tags to categories for each check-in. A single category is identified by the processors from the determined one or more categories for each check-in. Data associating each check-in is stored by the processors in association with the identified category for each check-in. Data representing the plurality of check-ins and the respective single category for each check-in is outputted for display by the processors.