Abstract: Disclosed herein is method for conjugating a metal chelating agent to a functionalized dextran by reacting a chelator with an aminated dextran backbone, where the chelator comprises a one, and only one, derivatized carboxylic acid group to form a chelator-dextran complex. In certain aspects, the dextran-chelator complex is substantially free of intra- or intermolecular crosslinking. In certain aspects, the functionalized dextran is an amine dextran, an alkynyl dextran, or a thiol dextran. In exemplary implementations, the functionalized dextran is an amine dextran. In further embodiments, one and only one carboxylic acid group on the chelating agent is derivatized as a N-hydroxysuccinimide (NHS) ester.

Abstract: Disclosed is a method for increase target specificity of a mannosylated dextran therapeutic or diagnostic compound by administering at least a blocking composition comprising a backbone and one or more CD206 targeting moieties attached thereto; administering an effective amount of the mannosylated dextran therapeutic or diagnostic compound comprising a dextran backbone and one or more CD206 targeting moieties and one or more therapeutic agents attached thereto. In exemplary implementations, the molecular mass of the blocking composition backbone is at least about two times larger than the molecular mass of the mannosylated dextran backbone compound.

Abstract: Various embodiments are described for systems and methods for providing visual feedback indicating a touch selection of an element on a touch-sensitive display. In one example, the method may include displaying the element in a first orientation on the display. A rotation scaling factor may be established that is based on a distance between an element, point of reference and a display point of reference. Based on the rotation scaling factor, a rotation amount of the element is determined. When a touch selection of the element is received, the method includes rotating the element by the rotation amount to a second orientation, and displaying the element in the second orientation on the display.

Abstract: Various embodiments are described for systems and methods for providing visual feedback indicating a touch selection of an element on a touch-sensitive display. In one example, the method may include displaying the element in a first orientation on the display. A rotation scaling factor may be established that is based on a distance between an element, point of reference and a display point of reference. Based on the rotation scaling factor, a rotation amount of the element is determined. When a touch selection of the element is received, the method includes rotating the element by the rotation amount to a second orientation, and displaying the element in the second orientation on the display.