Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.

Abstract: A printed circuit board having an electrically insulative layer and a conductive solder pad. The conductive solder pad is disposed at least partially over the electrically insulative layer, and defines a solder contact area. The solder contact area is configured for making an electrical connection to an electrical component via laser soldering. The printed circuit board further includes a solder mask coating the conductive solder pad and defining an exposed area of the conductive solder pad. The conductive solder pad protects the electrically insulative layer from incident heat during the laser soldering by extending a length underneath the solder mask along a periphery of the exposed area.

Abstract: Technologies and implementations for a defibrillator electrode having communicative capabilities are generally disclosed.

Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.

Abstract: Described herein are thin metal strips having hot rolled exterior side surfaces characterized as being primarily or substantially free of all prior austenite grain boundaries, or at least primarily or substantially free of all prior austenite grain boundaries, and including elongated surface structure. As a result, because the prior austenite grain boundaries are not primarily or substantially present, all such prior austenite grain boundaries are not susceptible to grain boundary etching due to acid etching or pickling. In particular examples, the thin metal strips undergo hot rolling performed with a coefficient of friction equal to or greater than 0.20 with or without use of lubrication.

Abstract: Systems and methods of applying a texture on a substrate include applying a texture to the substrate with a work stand of a coil-to-coil process. The work stand includes an upper work roll and a lower work roll vertically aligned with the upper work roll. At least one of the upper work roll and the lower work roll includes the texture. Applying the texture includes applying, by the upper work roll and a lower work roll, a work roll pressure on an upper surface and a lower surface of the substrate. The method further includes adjusting a contact pressure parameter of the work stand such that the work stand provides a desired contact pressure distribution across the width of the substrate and a desired thickness profile of the edges of the substrate while an overall thickness of the substrate remains substantially constant.

Abstract: Systems and apparatus for continuously casting thin strip where one or more expansion rings are positioned within at least one of a pair of casting rolls, and automatically measuring a thickness of the cast strip close to the first side edge of the strip using at least one sensor. If the thickness measured is too thin, automatically decreasing the radial dimension of the expansion ring arranged in close proximity to the first side edge to cause the cylindrical tube to contract and increase the thickness of the cast strip during casting. If the thickness measured indicates that the thickness of the cast strip is too thick, automatically increasing the radial dimension of the expansion ring arranged in close proximity to the first side edge to cause the cylindrical tube to expand and reduce the thickness of the cast strip during casting.

Abstract: Technologies and implementations for a defibrillator electrode having communicative capabilities are generally disclosed.

Abstract: This disclosure concerns methods and apparatus for continuously casting thin strip where one or more expansion rings are positioned within at least one of a pair of casting rolls, and automatically measuring a thickness of the cast strip close to the first side edge of the strip using at least one sensor, and if the thickness measured is too thin, automatically decreasing the radial dimension of the expansion ring arranged in close proximity to the first side edge to cause the cylindrical tube to contract and increase the thickness of the cast strip during casting, and if the thickness measured indicates that the thickness of the cast strip is too thick, automatically increasing the radial dimension of the expansion ring arranged in close proximity to the first side edge to cause the cylindrical tube to expand and reduce the thickness of the cast strip during casting.

Abstract: Described herein are thin metal strips having hot rolled exterior side surfaces characterized as being primarily or substantially free of all prior austenite grain boundaries, or at least primarily or substantially free of all prior austenite grain boundaries, and including elongated surface structure. As a result, because the prior austenite grain boundaries are not primarily or substantially present, all such prior austenite grain boundaries are not susceptible to grain boundary etching due to acid etching or pickling. In particular examples, the thin metal strips undergo hot rolling performed with a coefficient of friction equal to or greater than 0.20 with or without use of lubrication.

Abstract: Described herein are thin metal strips having hot rolled exterior side surfaces characterized as being primarily or substantially free of all prior austenite grain boundaries, or at least primarily or substantially free of all prior austenite grain boundaries, and including elongated surface structure. As a result, because the prior austenite grain boundaries are not primarily or substantially present, all such prior austenite grain boundaries are not susceptible to grain boundary etching due to acid etching or pickling. In particular examples, the thin metal strips undergo hot rolling performed with a coefficient of friction equal to or greater than 0.20 with or without use of lubrication.

Abstract: Methods and apparatus for continuously casting thin strip where one or more expansion rings are positioned within at least one of a pair of casting rolls, and automatically measuring a thickness of the cast strip close to the first side edge of the strip using at least one sensor, and if the thickness measured is too thin, automatically decreasing the radial dimension of the expansion ring arranged in close proximity to the first side edge to cause the cylindrical tube to contract and increase the thickness of the cast strip during casting, and if the thickness measured indicates that the thickness of the cast strip is too thick, automatically increasing the radial dimension of the expansion ring arranged in close proximity to the first side edge to cause the cylindrical tube to expand and reduce the thickness of the cast strip during casting.

Abstract: Medical device, system, method for capturing medical images includes an image capture and processing portion and an interchangeable medical tool portion. The image capture and processing portion is configured to capture and process a photo image, a video stream of images, or a coded image. The interchangeable medical tool portion is configured to connect to the image capture and processing portion. The image capture and processing portion further includes a configuration module configured to detect a connection of the medical tool portion to the image capture and processing portion, determine the type of the interchangeable medical tool portion connected, and adapt the image capture and processing portion to the detected type of the medical tool portion. The medical device may transmit medical images to an external device for interpretation by an expert, providing coaching to the user of the medical device, and for asset management, decision support, and/or other purposes.

Abstract: A computing architecture, system and method are disclosed for use in a medical device for providing decision support to a caregiver. The computing architecture includes a memory, a processor in communication with the memory, and an instance of a primary rules-based service configured to provide instruction events, the instance providing a primary processing thread of instruction events for coaching treatment of a patient. A software manager module includes an artificial intelligence architecture. The artificial intelligence architecture is configured to provide an instance of a conditional rules-based service for providing instruction events. The instance provided by the artificial intelligence architecture provides a processing thread of instruction events for coaching treatment of a patient that is independent of the primary processing thread and is configured to trigger an action on the occurrence of a pre-defined set of input conditions.

Abstract: Described herein are thin metal strips having hot rolled exterior side surfaces characterized as being primarily or substantially free of all prior austenite grain boundaries, or at least primarily or substantially free of all prior austenite grain boundaries, and including elongated surface structure. As a result, because the prior austenite grain boundaries are not primarily or substantially present, all such prior austenite grain boundaries are not susceptible to grain boundary etching due to acid etching or pickling. In particular examples, the thin metal strips undergo hot rolling performed with a coefficient of friction equal to or greater than 0.20 with or without use of lubrication.

Abstract: Styli for generating alert notifications to prevent unintentional marking of interactive devices are disclosed. A disclosed stylus includes a housing and a processor. The housing is to interchangeably receive a physically marking nib and an electronic marking nib. The processor is carried by the housing. The processor is to determine a received nib is the physically marking nib. The processor is further to determine a distance between the stylus and an interactive device satisfies a threshold. The processor is further to generate an alert notification based on the received nib being the physically marking nib and the distance between the stylus and the interactive device satisfying the threshold.

Abstract: Systems and methods of applying a texture on a substrate include applying a texture to the substrate with a work stand of a coil-to-coil process. The work stand includes an upper work roll and a lower work roll vertically aligned with the upper work roll. At least one of the upper work roll and the lower work roll includes the texture. Applying the texture includes applying, by the upper work roll and a lower work roll, a work roll pressure on an upper surface and a lower surface of the substrate. The method further includes adjusting a contact pressure parameter of the work stand such that the work stand provides a desired contact pressure distribution across the width of the substrate and a desired thickness profile of the edges of the substrate while an overall thickness of the substrate remains substantially constant.

Abstract: A flatness control system includes a work stand of a finishing line, a plurality of actuators, a flatness measuring device, and a controller. The work stand includes a pair of vertically aligned work rolls. A first work roll of the pair of work rolls includes a plurality of flatness control zones configured to apply a localized pressure to a corresponding region on a substrate. Each actuator corresponds with a one of the plurality of flatness control zones. The flatness measuring device is configured to measure an actual flatness profile of the substrate. The controller is configured to adjust the plurality of actuators such that the localized pressures modify the actual flatness profile to achieve the desired flatness profile at the exit of the stand. The thickness and a length of the substrate remain substantially constant when the substrate exits the work stand.

Abstract: A computing architecture, system and method are disclosed for use in a medical device for providing decision support to a caregiver. The computing architecture includes a memory, a processor in communication with the memory, and an instance of a primary rules-based service configured to provide instruction events, the instance providing a primary processing thread of instruction events for coaching treatment of a patient. A software manager module includes an artificial intelligence architecture. The artificial intelligence architecture is configured to provide an instance of a conditional rules-based service for providing instruction events. The instance provided by the artificial intelligence architecture provides a processing thread of instruction events for coaching treatment of a patient that is independent of the primary processing thread and is configured to trigger an action on the occurrence of a pre-defined set of input conditions.

Abstract: This disclosure concerns methods and apparatus for continuously casting thin strip where one or more expansion rings are positioned within at least one of a pair of casting rolls, and automatically measuring a thickness of the cast strip close to the first side edge of the strip using at least one sensor, and if the thickness measured is too thin, automatically decreasing the radial dimension of the expansion ring arranged in close proximity to the first side edge to cause the cylindrical tube to contract and increase the thickness of the cast strip during casting, and if the thickness measured indicates that the thickness of the cast strip is too thick, automatically increasing the radial dimension of the expansion ring arranged in close proximity to the first side edge to cause the cylindrical tube to expand and reduce the thickness of the cast strip during casting.