Abstract: Provided are methods and systems for determining the clinical significance of a genetic variant. The methods entail determining, for the variant, (a) a function score based on known impact of the variant on a biological function of a cell or protein, (b) a frequency score based on the frequency of the variant in a population, (c) a co-occurrence score based on how the variant co-occurs with a reference variant having known clinical significance relating to a clinical disease or condition, and (d) a family segregation score based on how the variant segregates with a disease or condition in a family; and aggregating, on a computer, the function score, the frequency score, the co-occurrence score, the family segregation score to generate a clinical significance score indicating the clinical significance of the genetic variant.

Abstract: Provided are methods and systems for determining the clinical significance of a genetic variant. The methods entail determining, for the variant, (a) a function score based on known impact of the variant on a biological function of a cell or protein, (b) a frequency score based on the frequency of the variant in a population, (c) a co-occurrence score based on how the variant co-occurs with a reference variant having known clinical significance relating to a clinical disease or condition, and (d) a family segregation score based on how the variant segregates with a disease or condition in a family; and aggregating, on a computer, the function score, the frequency score, the co-occurrence score, the family segregation score to generate a clinical significance score indicating the clinical significance of the genetic variant.

Abstract: Provided are methods and systems for determining the clinical significance of a genetic variant. The methods entail determining, for the variant, (a) a function score based on known impact of the variant on a biological function of a cell or protein, (b) a frequency score based on the frequency of the variant in a population, (c) a co-occurrence score based on how the variant co-occurs with a reference variant having known clinical significance relating to a clinical disease or condition, and (d) a family segregation score based on how the variant segregates with a disease or condition in a family; and aggregating, on a computer, the function score, the frequency score, the co-occurrence score, the family segregation score to generate a clinical significance score indicating the clinical significance of the genetic variant.

Abstract: A method and system for contextualizing and presenting user data. The method includes collecting information comprising service activity data and sensor data from one or more electronic devices. The information is organized based on associated time for the collected information. One or more of content information and service information of potential interest are provided to the one or more electronic devices based on one or more of user context and user activity.

Abstract: An apparatus and a method for aligning a vertical shaft or multiple axially coupled vertical shafts in a hydroelectric turbine generator or a similar vertical-shaft system, and for providing precise plumb inclination alignment of a vertical rotating shaft. Precision inclinometers attached to the vertical shaft measure plumb inclination. Proximity probe displacement devices mounted externally of the vertical shaft measure radial movement, throw, or run out at various shaft elevations as the shaft is rotated relative to a fixed point. Data acquisition devices and communication devices accumulate and transmit alignment data to a micro-computer which receives and processes such data. Methods of defining shaft plumb inclination in a static single rotational position and defining plumb inclination of the virtual centerline of a shaft's rotational throw position. A method of swinging, tilting, or adjusting a vertical shaft to a corrected or different plumb position relative to the earth's gravity.

Abstract: A coalescer media flexible container for retaining coalescer media in the coalescer chamber of an oil-water separator is provided having a flexible enclosure and a randomly arranged, loosely packed coalescing medium. The flexible container has a top surface connected to a bottom surface. The flexible enclosure conforms to the shape of the coalescer chamber in which the flexible enclosure is placed. The flexible enclosure has an interior, with the flexible enclosure fabricated so as to permit liquids to easily pass into the interior of the flexible enclosure where the randomly arranged, loosely packed coalescing medium is retained. The flexible enclosure is preferably fabricated from a group of materials including plastic mesh, reinforced aerated plastic bags, wire mesh, fabric mesh, and netting. Furthermore, in at least one embodiment of the invention, a planar sheetform member is located in the interior of the flexible enclosure directly adjacent the bottom surface.

Abstract: A process and equipment for plasma sterilization in which articles in a sterilizing chamber are taken through at least one combination sterilizing cycle. The articles to be sterilized may include the interior of a vessel or chamber. In that case, the vessel or chamber itself may serve as a sterilizing chamber and connects to the plasma generating chamber. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped.

Abstract: This invention relates to a nonaqueous liquid detergent containing a surfactant selected from the alkali metal salts of C10-C16 alkylbenzene sulfonic acid having 2-phenyl isomer content lower than 22%.

Abstract: The compositions of the present invention consist essentially of (I) a reaction product, (II) a nonaqueous liquid continuous phase, and (III) a moderately hydrophobic particulate stabilizing aid. Component (I) is prepared by heating a mixture of (i) a polyorganosiloxane fluid, (ii) a silicon compound, (iii) a finely divided filler and (iv) a catalytic amount of a compound for promoting the reaction of components (i) to (iii) at a temperature of 50.degree. C. to 300.degree. C. The compositions of the present invention can additionally contain (IV) at least one nonionic silicone surfactant, and (V) a nonreinforcing inorganic filler.

Abstract: Liquid detergent compositions containing a branched anionic surfactant. These compositions are low sudsing and have improved hydrophobic greasy soil removal performance.

Abstract: A process for preparing a suds controlling composition suitable for incorporation into laundry detergent products comprises absorbing into the pores of porous silica a sufficient amount of a surfactant-containing solution to ensure wetting of the porous silica, dispersing the porous silica having the surfactant-containing solution absorbed therein in a silicone oil and mixing the dispersion with a dispersing agent.

Abstract: A process for plasma sterilization in which articles in a sterilizing chamber are taken through at least one combination sterilizing cycle. The articles to be sterilized may include the interior of a vessel or chamber. In that case, the vessel or chamber itself may serve as a sterilizing chamber and connects to the plasma generating chamber. Each combination sterilizing cycle includes a pulsed treatment with gaseous antimicrobial agent, removal of the gaseous antimicrobial agent, and a plasma treatment. The pulsed treatment includes one or more pulse-vacuum cycles, each pulse-vacuum cycle includes the steps of evacuating the sterilizing chamber and exposing the article to the gaseous antimicrobial agent with a predetermined pressure profile during a predetermined time. The gaseous antimicrobial agent is preferably carried in a gas mixture with a nonreactive carrier gas. In one embodiment, the predetermined pressure is pulsed. In another embodiment, it is ramped.

Abstract: The present invention provides an antifoam agent for inclusion in a detergent composition in liquid form, comprising a silicone antifoam compound, a surfactant-containing solution and a particulate stabilizing aid. The present invention also provides detergent compositions comprising said antifoam agent.