Abstract: The present disclosure generally relates to shallow trench isolation (STI) processing with local oxidation of silicon (LOCOS), and an integrated circuit formed thereby. In an example, an integrated circuit includes a semiconductor layer, a LOCOS layer, an STI structure, and a passive circuit component. The semiconductor layer is over a substrate. The LOCOS layer is over the semiconductor layer. The STI structure extends into the semiconductor layer. The passive circuit component is over and touches the LOCOS layer.

Abstract: A holder for mounting a sensory device to a musical instrument includes a bracket having a plurality of first connector elements, a locking mechanism for fixing the sensory device to the bracket; and a plurality of hanger members. The bracket supports the sensory device and each of the hanger members connects at least one of the first connector elements to at least one of a plurality of second connector elements attached to the musical instrument. The second connector elements being spaced apart from each other and the hanger members hold the bracket at a predetermined position.

Abstract: A holder for mounting a sensory device to a musical instrument comprises a bracket having a plurality of first connector elements, a locking mechanism for fixing the sensory device to the bracket; and a plurality of hanger members. The bracket supports the sensory device and each of the hanger members connects at least one of the first connector elements to at least one of a plurality of second connector elements attached to the musical instrument. The second connector elements being spaced apart from each other and the hanger members hold the bracket at a predetermined position.

Abstract: Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods are disclosed.

Abstract: Genistein is an excellent transthyretin amyloidogenesis inhibitor and exhibits excellent binding selectivity in plasma. Treatment of patients having transthyretin amyloidosis with therapeutic agents containing genistein is disclosed to ameliorate the disease condition.

Abstract: Bisaryloxime ethers and bisarylhydroazones are shown to be effective for inhibiting formation of amyloid fibrils of transthyretin.

Abstract: Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods, screening methods, as well as specific transthyretin stabilizing compounds are disclosed.

Abstract: Compounds, compositions and methods are provided for stabilizing transthyretin and for treating, preventing, or ameliorating one or more symptoms of transthyretin mediated diseases. In one embodiment, the compounds are biphenyls and related compounds.

Abstract: Dibenzofuran-4,6-dicarboxylic acid core structures having an aromatic substituent appended onto the at the C1 position using three different types of linkages are disclosed herein and shown to afford exceptional amyloidogenesis inhibitors that display increased affinity and greatly increased binding selectivity to TTR over all the other plasma proteins, relative to lead compound 1. It is further disclosed herein that these compounds function by imposing kinetic stabilization on the TTR tetramer.