Patents by Inventor Jeffery M. Coller

Jeffery M. Coller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for increasing protein expression and/or treating a haploinsufficiency disorder
    Patent number: 12281314
    Abstract: A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon.
    Type: Grant
    Filed: September 26, 2019
    Date of Patent: April 22, 2025
    Assignees: CASE WESTERN RESERVE UNIVERSITY, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • METHODS AND COMPOSITIONS FOR TREATING A PREMATURE STOP CODON-MEDIATED DISORDER
    Publication number: 20240050594
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Application
    Filed: April 3, 2023
    Publication date: February 15, 2024
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • Methods and compositions for treating a premature stop codon-mediated disorder
    Patent number: 11617802
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Grant
    Filed: January 16, 2021
    Date of Patent: April 4, 2023
    Assignees: CASE WESTERN RESERVE UNIVERSITY, WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • METHODS OF MODULATING NUCLEIC ACID STABILITY AND PROTEIN EXPRESSION
    Publication number: 20220259606
    Abstract: A synthetic nucleic acid which encodes a protein wherein at least one optimal or non-optimal codon in a wild type nucleic acid encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.
    Type: Application
    Filed: February 1, 2022
    Publication date: August 18, 2022
    Inventors: Jeffery M. Coller, Kristian E. Baker
  • METHODS AND COMPOSITIONS FOR INCREASING PROTEIN EXPRESSION AND/OR TREATING A HAPLOINSUFFICIENCY DISORDER
    Publication number: 20220073933
    Abstract: A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon.
    Type: Application
    Filed: September 26, 2019
    Publication date: March 10, 2022
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • Methods of modulating nucleic acid stability and protein expression
    Patent number: 11236345
    Abstract: A synthetic nucleic acid which encodes a protein wherein at least one optimal or non-optimal codon in a wild type nucleic acid encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.
    Type: Grant
    Filed: March 9, 2016
    Date of Patent: February 1, 2022
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jeffery M. Coller, Kristian E. Baker
  • METHODS AND COMPOSITIONS FOR TREATING A PREMATURE STOP CODON-MEDIATED DISORDER
    Publication number: 20210299279
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Application
    Filed: January 16, 2021
    Publication date: September 30, 2021
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • Methods and compositions for treating a premature stop codon-mediated disorder
    Patent number: 10905778
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Grant
    Filed: October 28, 2019
    Date of Patent: February 2, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jeffery M. Coller, Thomas Sweet
  • Methods of modulating mRNA stability and protein expression
    Patent number: 10883109
    Abstract: A synthetic cDNA which encodes a protein wherein at least one optimal or non-optimal codon in a wild type DNA encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: January 5, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Jeffery M. Coller, Kristian E. Baker
  • METHODS OF MODULATING mRNA STABILITY AND PROTEIN EXPRESSION
    Publication number: 20200140872
    Abstract: A synthetic cDNA which encodes a protein wherein at least one optimal or non-optimal codon in a wild type DNA encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.
    Type: Application
    Filed: September 22, 2017
    Publication date: May 7, 2020
    Inventors: Jeffery M. Coller, Kristian E. Baker
  • METHODS AND COMPOSITIONS FOR TREATING A PREMATURE STOP CODON-MEDIATED DISORDER
    Publication number: 20200101174
    Abstract: Modified tRNAs can be used to express in a mammalian cell a functional gene product encoded by a gene containing a premature stop codon and/or to treat a disease mediated by a premature stop codon.
    Type: Application
    Filed: October 28, 2019
    Publication date: April 2, 2020
    Inventors: Jeffery M. Coller, Thomas Sweet, Harvey Lodish
  • METHODS OF MODULATING mRNA STABILITY AND PROTEIN EXPRESSION
    Publication number: 20180135061
    Abstract: A synthetic cDNA which encodes a protein wherein at least one optimal or non-optimal codon in a wild type DNA encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.
    Type: Application
    Filed: September 22, 2017
    Publication date: May 17, 2018
    Inventors: Jeffery M. Coller, Kristian E. Baker
  • METHODS OF MODULATING NUCLEIC ACID STABILITY AND PROTEIN EXPRESSION
    Publication number: 20180112226
    Abstract: A synthetic nucleic acid which encodes a protein wherein at least one optimal or non-optimal codon in a wild type nucleic acid encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.
    Type: Application
    Filed: March 9, 2016
    Publication date: April 26, 2018
    Inventors: Jeffery M. Coller, Kristian E. Baker