Patents by Inventor Jeffery Mark Brown

Jeffery Mark Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220359177
    Abstract: Disclosed herein are various methods and apparatus for performing charge detection mass spectrometry (CDMS). In particular, techniques are disclosed for monitoring a detector signal from a CDMS device to determine how many ions are present in the ion trap (10) of the CDMS device. For example, if no ions are present the measurement can then be terminated early. Similarly, if more than one ion is present, the measurement can be terminated early, or ions can be removed from the trap (10) until only a single ion remains. Techniques are also provided for increasing the probability of there being a single ion in the trap (10). A technique for attenuating an ion beam is also provided.
    Type: Application
    Filed: May 16, 2022
    Publication date: November 10, 2022
    Applicant: Micromass UK Limited
    Inventors: Keith Richardson, Jeffery Mark Brown, David J. Langridge
  • Patent number: 11402385
    Abstract: A method of mass spectrometry determines if a mutated variant of a target protein is present in a sample. The method includes subjecting the sample to fragmentation so as to cause the target protein to fragment to form second generation fragment ions, and then mass analysing these fragment ions to obtain spectral data. The method determines if a mutated variant is present in the sample by determining that an ion in the spectral data has a mass to charge ratio that differs from the mass to charge ratio of an ion that would be observed if the target protein was a normal unmutated version of the target protein, and by an amount that corresponds to a mass difference that would be caused by the target protein being a mutated variant of the target protein.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: August 2, 2022
    Assignee: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Michael Raymond Morris, Jonathan Williams, Brian Green
  • Patent number: 11367602
    Abstract: Disclosed herein are various methods and apparatus for performing charge detection mass spectrometry (CDMS). In particular, techniques are disclosed for monitoring a detector signal from a CDMS device to determine how many ions are present in the ion trap (10) of the CDMS device. For example, if no ions are present the measurement can then be terminated early. Similarly, if more than one ion is present, the measurement can be terminated early, or ions can be removed from the trap (10) until only a single ion remains. Techniques are also provided for increasing the probability of there being a single ion in the trap (10). A technique for attenuating an ion beam is also provided.
    Type: Grant
    Filed: February 22, 2019
    Date of Patent: June 21, 2022
    Assignee: Micromass UK Limited
    Inventors: Keith Richardson, Jeffery Mark Brown, David J. Langridge
  • Patent number: 11342175
    Abstract: A mass spectrometer comprising: a multi-reflecting time of flight (MRTOF) mass analyser or mass separator having two gridless ion mirrors 2 that are elongated in a first dimension (Z-dimension) and configured to reflect ions multiple times in a second orthogonal dimension (X-dimension) as the ions travel in the first dimension; the spectrometer configured to operate in: (i) a first mode for ions having a first rate of interaction with background gas molecules in the mass analyser or separator, such that the ions are reflected a first number of times between the ion mirrors 2; and (ii) a second mode for ions having a second, higher rate of interaction with background gas molecules in the mass analyser or separator, such that ions are reflected a second, lower number of times between the ion mirrors 2.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: May 24, 2022
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Boris Kozlov
  • Patent number: 11328917
    Abstract: A MALDI ion source is disclosed comprising: a target plate (2) having a front surface (4), a rear surface (6), and at least one sample receiving well (9) for receiving a liquid sample or at least one sample receiving channel (8) extending from an opening (12) in the rear surface (6) to an opening (14) in the front surface (4) for receiving a liquid sample (10), wherein each well (9) or channel (8) has a volume of ?1 ?L. The ion source also comprise a laser (16) for ionising a liquid sample (10) on or in the target plate (2), wherein the laser (16) is a pulsed laser set up and configured to have a pulsed repetition rate of ?20 Hz, or is a continuous laser.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: May 10, 2022
    Assignee: Micromass UK Limited
    Inventor: Jeffery Mark Brown
  • Patent number: 11127576
    Abstract: An ambient or atmospheric pressure ion source is disclosed that comprises a laser source (1) that generates ions and/or neutral particles from a target (2). A transfer device (10) causes the ions and/or neutral particles to pass along a first path or axis within the transfer device (10), while a secondary activation device (6) directs laser radiation or photons along, across or over at least a portion of the first path or axis to cause secondary activation of the ions and/or neutral particles.
    Type: Grant
    Filed: November 17, 2017
    Date of Patent: September 21, 2021
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Steven Derek Pringle
  • Publication number: 20210285956
    Abstract: A method of ionising a sample is disclosed comprising nebulising a sample which includes first biomolecules such as bovine insulin comprising one or more disulphide (S—S) bonds. A stream of droplet or charged droplets comprising one or more disulphide (S—S) bonds is directed so as to impact upon a target (106) or electrode so as to cause the breaking of a portion of the disulphide bonds. Alternatively, charged droplets may pass through an electric field region determined by an electrode (106) arranged downstream of a nebuliser or electrospray probe and an ion inlet (104) of a mass spectrometer so as to cause the breaking of a portion of the disulphide bonds.
    Type: Application
    Filed: April 13, 2018
    Publication date: September 16, 2021
    Inventors: Stevan Bajic, Jeffery Mark Brown
  • Publication number: 20210280408
    Abstract: An ion source is provided comprising a nebuliser or electrospray probe (1) for nebulising a sample and an impact surface or target electrode (5). The impact surface or target electrode (5) comprises a tarnishable or oxidisable metal or an alloy comprising tarnishable or oxidisable metal. Also provided is an ion source comprising a nebuliser or electrospray probe with a central wire comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal or an alloy comprising a tarnishable or oxidisable metal. Adducts with relatively heavy metals result in simplified multiply-charged mass spectra that are easier to interpret.
    Type: Application
    Filed: July 4, 2019
    Publication date: September 9, 2021
    Applicant: Micromass UK Limited
    Inventors: Stevan Bajic, Jeffery Mark Brown
  • Patent number: 11094521
    Abstract: Disclosed herein is an ion analysis instrument comprising a Time of Flight (“TOF”) mass analyser comprising a reflectron. The instrument is operable in at least a first mode and a second mode, wherein in said first mode ions are caused to turn around at a first point in the reflectron and wherein in said second mode ions are caused to turn around at a second point in the reflectron such that the distance traveled by ions within the Time of Flight mass analyser is greater in the second mode than the distance traveled by ions within the Time of Flight mass analyser in the first mode. In this way, the operating modes can be selectively optimised for the analysis of ions of different masses.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: August 17, 2021
    Assignee: MICROMASS UK LIMITED
    Inventor: Jeffery Mark Brown
  • Publication number: 20210193451
    Abstract: A mass spectrometer comprising: a multi-reflecting time of flight (MRTOF) mass analyser or mass separator having two gridless ion mirrors 2 that are elongated in a first dimension (Z-dimension) and configured to reflect ions multiple times in a second orthogonal dimension (X-dimension) as the ions travel in the first dimension; the spectrometer configured to operate in: (i) a first mode for ions having a first rate of interaction with background gas molecules in the mass analyser or separator, such that the ions are reflected a first number of times between the ion mirrors 2; and (ii) a second mode for ions having a second, higher rate of interaction with background gas molecules in the mass analyser or separator, such that ions are reflected a second, lower number of times between the ion mirrors 2.
    Type: Application
    Filed: May 3, 2019
    Publication date: June 24, 2021
    Applicant: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Boris Kozlov
  • Publication number: 20210166930
    Abstract: A MALDI ion source is disclosed comprising: a target plate (2) having a front surface (4), a rear surface (6), and at least one sample receiving well (9) for receiving a liquid sample or at least one sample receiving channel (8) extending from an opening (12) in the rear surface (6) to an opening (14) in the front surface (4) for receiving a liquid sample (10), wherein each well (9) or channel (8) has a volume of ?1 ?L. The ion source also comprise a laser (16) for ionising a liquid sample (10) on or in the target plate (2), wherein the laser (16) is a pulsed laser set up and configured to have a pulsed repetition rate of ?20 Hz, or is a continuous laser.
    Type: Application
    Filed: April 12, 2018
    Publication date: June 3, 2021
    Inventor: Jeffery Mark Brown
  • Patent number: 10991560
    Abstract: A method of mass or ion mobility spectrometry is disclosed that uses the Leidenfrost effect to cause a liquid to be repelled away from a heated surface so as to levitate above there-above. The repelled liquid is urged so as to move along the surface in a predetermined direction, for example, by the geometric configuration of the heated surface.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: April 27, 2021
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Steve Bajic, Steven Derek Pringle
  • Publication number: 20210118663
    Abstract: A method of producing ions from a sample is disclosed. The method comprises directing a spray of droplets onto a sample, and causing droplets comprising analyte from the sample to impact upon a surface so as to generate analyte ions.
    Type: Application
    Filed: April 11, 2018
    Publication date: April 22, 2021
    Inventors: Emrys Jones, Steven Derek Pringle, Jeffery Mark Brown
  • Publication number: 20200395202
    Abstract: Disclosed herein are various methods and apparatus for performing charge detection mass spectrometry (CDMS). In particular, techniques are disclosed for monitoring a detector signal from a CDMS device to determine how many ions are present in the ion trap (10) of the CDMS device. For example, if no ions are present the measurement can then be terminated early. Similarly, if more than one ion is present, the measurement can be terminated early, or ions can be removed from the trap (10) until only a single ion remains. Techniques are also provided for increasing the probability of there being a single ion in the trap (10). A technique for attenuating an ion beam is also provided.
    Type: Application
    Filed: February 22, 2019
    Publication date: December 17, 2020
    Inventors: Keith Richardson, Jeffery Mark Brown, David J. Langridge
  • Patent number: 10714325
    Abstract: A mass spectrometer is disclosed comprising a glow discharge device within the initial vacuum chamber of the mass spectrometer. The glow discharge device may comprise a tubular electrode located within an isolation valve, which is provided in the vacuum chamber. Reagent vapour may be provided through the tubular electrode, which is then subsequently ionised by the glow discharge. The resulting reagent ions may be used for Electron Transfer Dissociation of analyte ions generated by an atmospheric pressure ion source. Other embodiments are contemplated wherein the ions generated by the glow discharge device may be used to reduce the charge state of analyte ions by Proton Transfer Reaction or may act as lock mass or reference ions.
    Type: Grant
    Filed: November 21, 2016
    Date of Patent: July 14, 2020
    Assignee: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Martin Raymond Green, Steven Derek Pringle
  • Patent number: 10684288
    Abstract: A method of screening or testing a sample is disclosed that comprises ionising a native human hemoglobin sample to generate parent or precursor ions, subjecting the parent or precursor ions to Electron Transfer Dissociation fragmentation so as to generate a plurality of fragment ions, mass analysing the fragment ions and determining whether or not the fragment ions include fragment ions which are indicative of a variant of hemoglobin.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: June 16, 2020
    Assignee: MICROMASS UK LIMITED
    Inventors: Malcolm Anderson, Jeffery Mark Brown, Jonathan Williams
  • Patent number: 10490394
    Abstract: A mass spectrometer is disclosed wherein highly charged fragment ions resulting from Electron Transfer Dissociation fragmentation of parent ions are reduced in charge state within a Proton Transfer Reaction cell by reacting the fragment ions with a neutral superbase reagent gas such as Octahydropyrimidolazepine.
    Type: Grant
    Filed: September 11, 2017
    Date of Patent: November 26, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Weibin Chen, Asish B. Chakraborty, John Charles Gebler, Jeffery Mark Brown
  • Publication number: 20190326108
    Abstract: An ambient or atmospheric pressure ion source is disclosed that comprises a laser source (1) that generates ions and/or neutral particles from a target (2). A transfer device (10) causes the ions and/or neutral particles to pass along a first path or axis within the transfer device (10), while a secondary activation device (6) directs laser radiation or photons along, across or over at least a portion of the first path or axis to cause secondary activation of the ions and/or neutral particles.
    Type: Application
    Filed: November 17, 2017
    Publication date: October 24, 2019
    Inventors: Jeffery Mark Brown, Steven Derek Pringle
  • Publication number: 20190287778
    Abstract: A method of mass or ion mobility spectrometry is disclosed that uses the Leidenfrost effect to cause a liquid to be repelled away from a heated surface so as to levitate above there-above. The repelled liquid is urged so as to move along the surface in a predetermined direction, for example, by the geometric configuration of the heated surface.
    Type: Application
    Filed: May 30, 2019
    Publication date: September 19, 2019
    Applicant: Micromass UK Limited
    Inventors: Jeffery Mark Brown, Steve Bajic, Steven Derek Pringle
  • Patent number: 10388503
    Abstract: Methods and apparatuses for transmitting ions through an aperture are described. In one embodiment, a mass spectrometer may include an ion source; an aperture; a flight region arranged between the ion source and aperture for separating ions according to their mass to charge ratio; and ion optics arranged and configured for causing ions to be reflected or deflected while they separate according to mass to charge ratio in the flight region and such that the ions are focused to a geometrical focal point at the aperture so that the ions are transmitted through the aperture. The multi-reflecting or multi-deflecting ion optics provides a relatively long flight path for the ions, while naturally converging the ion beam to a focus. As this focus is arranged at the aperture, it enables the aperture to be made relatively small while still maintaining high ion transmission efficiency.
    Type: Grant
    Filed: April 16, 2018
    Date of Patent: August 20, 2019
    Assignee: MICROMASS UK LIMITED
    Inventors: Jeffery Mark Brown, Paul Murray