Patents by Inventor Jeffery Schlom

Jeffery Schlom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for producing monoclonal antibodies reactive with human breast cancer
    Patent number: 4522918
    Abstract: Monoclonal antibodies demonstrating a reactivity with human breast cancer are produced. The hybridoma cultures secreting immunoglobins are produced by hydridoma technology. Splenic lymphocytes of mice, immunized with membrane-enriched fractions of metastatic human mammary carcinoma tissue are fused with the NS-1 non-immunoglobulin-secreting murine myeloma cell line. Screening of immunoglobulin reactivities and double cloning of cultures yielded 11 monoclonal antibodies that demonstrated activities with the surface of human mammary tumor cells and not with the surface of apparently normal human tissues. These monoclonal antibodies aid in the diagnosis, prognosis and treatment of human breast cancer.
    Type: Grant
    Filed: December 15, 1981
    Date of Patent: June 11, 1985
    Inventors: Jeffery Schlom, David Colcher, Marianna Nuti, Patricia H. Hand, Faye Austin