Patents by Inventor Jeffery Stavenhagen

Jeffery Stavenhagen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineering Fc Antibody Regions to Confer Effector Function
    Publication number: 20120263711
    Abstract: The present invention relates to molecules having a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region. These modified molecules confer an effector function to a molecule, where the parent molecule does not detectably exhibit this effector function. In one embodiment, the variant Fc region binds Fc?RIIIA and/or Fc?RIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region. The molecules of the invention have particular utility in treatment, prevention or management of a disease or disorder, in a sub-population of patients, wherein the target antigen is expressed at low levels in the target cell population.
    Type: Application
    Filed: May 24, 2012
    Publication date: October 18, 2012
    Applicant: MacroGenics, Inc.
    Inventors: Jeffery Stavenhagen, Scott Koenig
  • Engineering Fc Antibody regions to confer effector function
    Patent number: 7632497
    Abstract: The present invention relates to molecules having a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region. These modified molecules confer an effector function to a molecule, where the parent molecule does not detectably exhibit this effector function. In particular, the molecules of the invention have an increased effector cell function mediated by a Fc?R, such as, but not limited to, ADCC. In one embodiment, the variant Fc region binds Fc?RIIIA and/or Fc?RIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region.
    Type: Grant
    Filed: November 10, 2005
    Date of Patent: December 15, 2009
    Assignee: MacroGenics, Inc.
    Inventor: Jeffery Stavenhagen
  • Engineering Fc antibody regions to confer effector function
    Publication number: 20060134709
    Abstract: The present invention relates to molecules having a variant Fc region, wherein said variant Fc region comprises at least one amino acid modification relative to a wild-type Fc region. These modified molecules confer an effector function to a molecule, where the parent molecule does not detectably exhibit this effector function. In particular, the molecules of the invention have an increased effector cell function mediated by a Fc?R, such as, but not limited to, ADCC. In one embodiment, the variant Fc region binds Fc?RIIIA and/or Fc?RIIA with a greater affinity, relative to a comparable molecule comprising the wild-type Fc region.
    Type: Application
    Filed: November 10, 2005
    Publication date: June 22, 2006
    Inventors: Jeffery Stavenhagen, Scott Koenig