Abstract: In immunoglobulin light chain amyloidosis (AL), the unique antibody light chain (LC) protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. For treating AL patients, such as those with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, provided herein are small molecule compounds of Formula Ia, Formula Ib, and Formula II that are kinetic stabilizers of the native dimeric structure of full-length LCs, which compounds can slow or stop the amyloidogenicity cascade at its origin.

Abstract: Hinge assembly for mounting a door on a furniture frame for movement of the door between open and closed positions of the door relative to the furniture frame is provided comprising a mounting plate adapted to be affixed to a furniture frame member, an intermediate plate disposed atop of and slideably engaged to said mounting plate, a top plate disposed atop of and slideably engaged to said intermediate plate and said mounting plate, said top plate comprising a body portion having a depending front face and at least one depending rear member, a hinge arm slideably engaged to said top plate, and a guide pin extending through an aperture in the at least one depending rear member under the body portion of the top plate, under a portion of the intermediate plate, and into a corresponding aperture in the front face of the top plate. The hinge assembly is adjustable such that the hinge arm can be adjusted in three dimensions relative to the mounting plate.

Abstract: Hinge assembly for mounting a door on a furniture frame for movement of the door between open and closed positions of the door relative to the furniture frame comprising a mounting plate adapted to be affixed to a furniture frame member, an intermediate plate disposed atop of and slideably engaged to said mounting plate, a top plate disposed atop of and slideably engaged to said intermediate plate and said mounting plate, a hinge arm slideably connected to said top plate, and a pin extending through a portion of said top plate, slideably extending through a portion of said intermediate plate such that said intermediate plate is slideable in a first direction along the axis of the pin, and slideably extending through a portion of said mounting plate such that said pin is slideable in a second direction perpendicular to the axis of the pin relative to the mounting plate. Further, the hinge assembly is adjustable such that the hinge arm can be adjusted in three dimensions relative to the mounting plate.

Abstract: Hinge assembly for mounting a door on a furniture frame for movement of the door between open and closed positions of the door relative to the furniture frame comprising a mounting plate adapted to be affixed to a furniture frame member an intermediate plate disposed atop of and slideably engaged to said mounting plate a top plate disposed atop of and slideably engaged to said intermediate plate and said mounting plate, and further comprising a hinge arm extending from a front portion thereof, and a guide pin extending through a rearward portion of said top plate, through a rearward portion of said intermediate plate, and through a rearward portion of said mounting plate such that said top plate is pivotable upon said guide pin. Further, the hinge assembly is adjustable such that the hinge arm can be adjusted in three dimensions relative to the mounting plate.